Conducive 3D porous mesh of poly(ε-caprolactone) made via emulsion electrospinning

Pal, Jit; Sharma, Shivani; Sanwaria, Sunita; Kulshreshtha, Ritu; Nandan, Bhanu; Srivastava, Rajiv K.

doi:10.1016/j.polymer.2014.06.067

Cited by 25 publications

(14 citation statements)

References 24 publications

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“…Electrospinning is therefore appropriate to get fibers with comparable dimensions to fibrils existing in the extracellular matrix (ECM), porous scaffolds suitable for cell colonization and materials with enhanced bioactivity. Cautions must be taken into account when toxic organic solvents are employed and, consequently, different emulsion processes have been considered [54][55][56].…”

Section: Electrospun Scaffolds Incorporating Hap Nanoparticlesmentioning

confidence: 99%

Biodegradable and Biocompatible Systems Based on Hydroxyapatite Nanoparticles

et al. 2017

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Abstract:Composites of hydroxyapatite (HAp) are widely employed in biomedical applications due to their biocompatibility, bioactivity and osteoconductivity properties. In fact, the development of industrially scalable hybrids at low cost and high efficiency has a great impact, for example, on bone tissue engineering applications and even as drug delivery systems. New nanocomposites constituted by HAp nanoparticles and synthetic or natural polymers with biodegradable and biocompatible characteristics have constantly been developed and extensive works have been published concerning their applications. The present review is mainly focused on both the capability of HAp nanoparticles to encapsulate diverse compounds as well as the preparation methods of scaffolds incorporating HAp. Attention has also been paid to the recent developments on antimicrobial scaffolds, bioactive membranes, magnetic scaffolds, in vivo imaging systems, hydrogels and coatings that made use of HAp nanoparticles.

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Section: Electrospun Scaffolds Incorporating Hap Nanoparticlesmentioning

confidence: 99%

Biodegradable and Biocompatible Systems Based on Hydroxyapatite Nanoparticles

et al. 2017

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“…Poly(ε‐caprolactone) (PCL) has been used in fabrication of electrospun nanofibers for medical applications such as tissue engineering, dressing, and controlled drug delivery applications due to proper mechanical and biodegradation properties . Despite these excellent properties, PCL due to insufficient biological recognition sites and poor intrinsic hydrophobicity has some drowpoints in bio applications such as desired cell adhesion .…”

Section: Introductionmentioning

confidence: 99%

“…8,9 Poly(ε-caprolactone) (PCL) has been used in fabrication of electrospun nanofibers for medical applications such as tissue engineering, dressing, and controlled drug delivery applications due to proper mechanical and biodegradation properties. 10 Despite these excellent properties, PCL due to insufficient biological recognition sites and poor intrinsic hydrophobicity has some drowpoints in bio applications such as desired cell adhesion. 11,12 A number of works are published on electrospinning of PCL in different solvent systems in the combination with relatively hydrophilic polymers such as chitosan, poly(vinyl alcohol) (PVA), collagen, silk, and gelatin (GEL).…”

Section: Introductionmentioning

confidence: 99%

Biphasic, tough composite core/shell PCL/PVA‐GEL nanofibers for biomedical application

Akbarzadeh

Pezeshki‐Modaress

Zandi

2019

J of Applied Polymer Sci

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Emulsion electrospinning using natural and synthetic polymers, including two dissimilar materials is a promising technique for nanofibers fabrication in a core/shell configuration for tissue engineering, controlled or sustained drug delivery and dressing applications. In this study, we designed and fabricated core/shell nanofibers based on polycaprolactone (PCL) as core material and poly(vinyl alcohol) (PVA)‐gelatin (GEL) blend as shell materials (PCL/PVA‐GEL) to achieve high mechanical properties, good cell growth, and proliferation via emulsion electrospinning. The effect of water to acetic acid ratio in the solvent system (8:2, 7:3, 6:4, 5:5) and also type and concentration (3, 5, 7 w/v %) of surfactant on emulsion stability and nanofibers morphology were investigated. The emulsion containing 2% Tween80 and 1% Span60 as surfactants were selected by considering the stability of emulsion and uniform fiber morphology. In the tensile strength and elongation at break, 53 and 8% increase in the crosslinked wet state of the PCL/PVA‐GEL nanofibers compared with PVA‐GEL nanofibers were observed respectively. The cell culture results indicated that the PCL/PVA‐GEL nanofibers surface has presented suitable interaction with fibroblast cells and cells attached and proliferated well on the fabricated substrate within 24 and 48 hours and also would be a good candidate for biomedical applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48713.

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“…Elastic microfibers with excellent elasticity and strength have potential applications in tissue engineering and strain sensor, which has attracted tremendous attention of researchers in biomedical areas due to their similar structure and properties to elastic fibers in human body and extracellular matrix . Several rubbery materials, such as polybutadiene, polyethylene oxide, cis 1,4‐polyisoprene (PI), ethylene/propylene/diene, syndiotactic 1,2‐polybutadiene, poly(styrene‐b‐isoprene), natural rubber (NR)/acrylonitrile butadiene styrene (ABS), polycaprolactone (PCL), polyurethane, and elastin, have been electrospun to get elastic nano‐/microfibers in recent years. Electrospinning is an efficient way to transfer polymer solution or melt into nano‐/microfibers.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and properties of elastic fibers from electrospinning natural rubber

Wang

Peng

et al. 2019

J of Applied Polymer Sci

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Electrospinning natural rubber (NR) to get elastic nano-/microfibers has attracted much attention. Suitable solvent such as tetrahydrofuran (THF) was selected by considering solubility, toxicity, and electrospinning results. Dynamic light scattering testing was used to measure the hydrodynamic diameter (D h ) of the solutions with different solvents and the critical concentrations (C*) of NR/THF solution. For NR solutions with the same concentration from different solvents, the larger D h the solution, the larger the electrospun fiber diameter. Stable electrospinning concentration window ranging from 25 to 50 g/L, which corresponds to 38 > [ŋ]C > 19, was identified. Mechanical properties of both electrospun NR fiber mats and single fibers were estimated from tensile testing. Fibrous mats with excellent elasticity at about 439 to 505% elongation were demonstrated; however, the elongation rate of single fibers was 44%. Electrospun fiber mats with high elasticity of NR materials can be potentially used in soft tissue engineering and strain sensor areas.

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Conducive 3D porous mesh of poly(ε-caprolactone) made via emulsion electrospinning

Cited by 25 publications

References 24 publications

Biodegradable and Biocompatible Systems Based on Hydroxyapatite Nanoparticles

Biodegradable and Biocompatible Systems Based on Hydroxyapatite Nanoparticles

Biphasic, tough composite core/shell PCL/PVA‐GEL nanofibers for biomedical application

Fabrication and properties of elastic fibers from electrospinning natural rubber

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