Conditioning solid tumor microenvironment through inflammatory chemokines and S100 family proteins

Nasser, Mohd W.; Elbaz, Mohamad; Ahirwar, Dinesh K.; Ganju, Ramesh K.

doi:10.1016/j.canlet.2015.05.002

Cited by 32 publications

(13 citation statements)

References 189 publications

(208 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…307, 308, 309 The role of S100 proteins in cancer is considered to be type and stage specific, and each type of cancer seems to exhibit a different S100 protein profile. 307 Several groups recently reviewed the intricate role of S100 proteins in cancer in great detail.…”

Section: S100mentioning

confidence: 99%

See 1 more Smart Citation

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

2016

View full text Add to dashboard Cite

Our immune system is based on the close collaboration of the innate and adaptive immune systems for the rapid detection of any threats to the host. Recognition of pathogen-derived molecules is entrusted to specific germline-encoded signaling receptors. The same receptors have now also emerged as efficient detectors of misplaced or altered self-molecules that signal tissue damage and cell death following, for example, disruption of the blood supply and subsequent hypoxia. Many types of endogenous molecules have been shown to provoke such sterile inflammatory states when released from dying cells. However, a group of proteins referred to as alarmins have both intracellular and extracellular functions which have been the subject of intense research. Indeed, alarmins can either exert beneficial cell housekeeping functions, leading to tissue repair, or provoke deleterious uncontrolled inflammation. This group of proteins includes the high-mobility group box 1 protein (HMGB1), interleukin (IL)-1α, IL-33 and the Ca2+-binding S100 proteins. These dual-function proteins share conserved regulatory mechanisms, such as secretory routes, post-translational modifications and enzymatic processing, that govern their extracellular functions in time and space. Release of alarmins from mesenchymal cells is a highly relevant mechanism by which immune cells can be alerted of tissue damage, and alarmins play a key role in the development of acute or chronic inflammatory diseases and in cancer development.

show abstract

Section: S100mentioning

confidence: 99%

“…307 Several groups recently reviewed the intricate role of S100 proteins in cancer in great detail. 307, 308, 309 …”

Section: S100mentioning

confidence: 99%

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

2016

View full text Add to dashboard Cite

show abstract

“…S100A4, as an extracellular protein, can stimulate angiogenesis and attract immune cells to the growing tumor-lesions as well as promote the secretion of various cytokines and growth factors into the tumor microenvironment. Therefore, S100A4 is considered as a metastasis-promoting protein [ 40 , 41 ]. Furthermore, extracellular S100A4 released by tumor and/or stromal cells alters the tumor microenvironment and enhances pro-metastatic activities such as stimulation of angiogenesis and numerous effects on leukocytes [ 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

S100A4 in cancer progression and metastasis: A systematic review

et al. 2017

View full text Add to dashboard Cite

Metastasis is the leading cause of cancer-related death and directly associates with cancer progression, resistance to anticancer therapy, and poor patient survival. Current efforts focusing on the underlying molecular mechanisms of cancer metastasis attract a special attention to cancer researchers. The epithelial-mesenchymal transition is a complex of molecular program during embryogenesis, inflammation, tissue fibrosis, and cancer progression and metastasis. S100A4, an important member of S100 family proteins, functions to increase the tumor progression and metastasis. The molecular mechanisms of S100A4 involving in the progression and metastasis are diverse in various malignant tumors. Detection of S100A4 expression becomes a promising candidate biomarker in cancer early diagnosis and prediction of cancer metastasis and therefore, S100A4 may be a therapeutic target. This review summarized up to date advancement on the role of S100A4 in human cancer development, progression, and metastasis and the underlying molecular events and then strategies to target S100A4 expression experimentally.

show abstract

“…26 In this work, one of the purposes of delivering Cur was to exploit its anti-inflammatory effect on the area around a tumor to achieve a combination therapy effect. Inflammatory cell models were established by NIH 3T3 cells stimulated with LPS.…”

Section: Anti-inflammation Effectsmentioning

confidence: 99%