Conditioned pain modulation predicts persistent pain after knee replacement surgery

Dürsteler, C.; Salazar, Y M Argumosa; Rodriguez, U Garcia‐Dubus; Pelfort, Xavier

doi:10.1097/pr9.0000000000000910

Cited by 11 publications

(10 citation statements)

References 30 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The outcome parameters reported for the 16 surgical studies included 6 on the WOMAC, 14,21,50,52,59,60 7 on a VAS score, 6,34,35,38,44–46 3 using a NRS 18,40,58 (Table 1), 1 using complex regional pain syndrome (CRPS) severity scores (CSS), 16 and 1 on the BPI. 21 The number of measured QST tests in each study ranged from 1 6,16,18,60 to 6. 21,34 A total of 13/16 studies (81%) reported statistically significant associations between preoperative QST and chronic postoperative pain after total knee arthroplasty.…”

Section: Resultsmentioning

confidence: 99%

“…Conditioned pain modulation was reported as a QST parameter in 9/16 studies (56%). 14,18,21,34,35,44,45,52,58…”

Section: Resultsmentioning

confidence: 99%

“…18 Conditioned pain modulation predicted postoperative pain in 3/9 (33%) studies. 18,35,58 Vaegter et al, 58 assessed preoperative CPM PPT 1 cold and found that an impaired CPM-effect was associated with 6-month postoperative pain intensities. Larsen et al, 35 assessed preoperative CPM cuff 1 cuff and found that impaired CPM was associated with 12 months postoperative pain scores.…”

Section: Conditioned Pain Modulationmentioning

confidence: 98%

See 2 more Smart Citations

Quantitative sensory testing as an assessment tool to predict the response to standard pain treatment in knee osteoarthritis: a systematic review and meta-analysis

Petersen,

Kilic,

Hertel

et al. 2023

PR9

View full text Add to dashboard Cite

Emerging evidence suggest that quantitative sensory testing (QST) may predict the treatment response to pain-relieving therapies. This systematic review and meta-analysis focus on the predictive value of QST for pain management of knee osteoarthritis (OA). MEDLINE and EMBASE were systematically searched for all studies from year 2000 to 2023 on pretreatment QST and treatment of OA including surgical, pharmaceutical, and nonsurgical and nonpharmaceutical therapies. Preclinical studies and reviews were excluded. The systematic review followed the PRISMA guidelines and was pre-registered on the Open Science Framework website (link: https://osf. io/4FETK/, Identifier: DOI 10.17605/OSF.IO/4FETK). Meta-analysis were conducted to demonstrate the strength of the pre-treatment QST predictions on pain outcomes after OA treatments. Sixteen surgical (all on total knee arthroplasty [TKA], N 5 1967), 5 pharmaceutical (4 on non-steroidal anti-inflammatory drugs [NSAIDs], N 5 271), and 4 exercise-based therapy studies (N 5 232) were identified. Pretreatment QST parameters predicted pain-relieving treatment outcomes in 81% of surgical, 100% of pharmaceutical, and 50% of exercise-based therapy studies. Meta-analyses found pretreatment QST profiles to predicted pain outcomes after TKA (random effects: 0.309, 95% confidence interval [CI]: 0.206-0.405, P , 0.001), NSAIDs (random effects: 0.323, 95% CI: 0.194-0.441, P , 0.001), and exercise-based therapies (random effects: 0.417, 95% CI: 0.138-0.635, P 5 0.004). The overall risk of bias for the included studies was low to moderate. This systematic review and meta-analysis demonstrate weak-to-moderate associations between pretreatment QST and pain outcomes after standard OA pain treatments. Based on this work, it is hypothesized that a subset of specific pain sensitive patients with OA exist and that these patients do not respond adequately to standard OA pain treatments.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Conditioned pain modulation was reported as a QST parameter in 9/16 studies (56%). 14,18,21,34,35,44,45,52,58…”

Section: Resultsmentioning

confidence: 99%

Section: Conditioned Pain Modulationmentioning

confidence: 98%

See 1 more Smart Citation

Quantitative sensory testing as an assessment tool to predict the response to standard pain treatment in knee osteoarthritis: a systematic review and meta-analysis

Petersen,

Kilic,

Hertel

et al. 2023

PR9

View full text Add to dashboard Cite

show abstract

“…Wang and colleagues used QST to predict which patients would develop chronic pain following thoracic surgery [39]. Similarly, Dursteler and colleagues showed that low descending pain inhibition, i.e., low conditioned pain modulation (CPM), as assessed by QST was associated withincreased risk for persistent pain following knee replacement surgery [40]. Zaferio and colleagues used QST findings to predict which participants would complete a pain management program and get relief [41].…”

Section: Qst In Precision Pain Managementmentioning

confidence: 99%

The Role of Quantitative Sensory Testing in Clinical Medicine and Research

Anastasi¹,

Capili²,

McMahon³

2022

J Clin Biomed Res

View full text Add to dashboard Cite

A healthy peripheral nervous system allows for perception of temperature, touch and vibration at normal levels of stimulation without hypersensitivity or pain and is a key determinant of quality of life. Quantitative sensory testing (QST) describes an array of noninvasive methods for quantifying sensory function and monitoring sensory loss among patients with or at-risk for peripheral neuropathy (PN). Like audiometry, QST quantifies patients’ subjective sensory experience with instrumentation that is precise and amenable to serial use. Thermal QST is the only diagnostic technology able to detect and quantify preclinical sensory deficit via direct patient feedback and merits wider use in clinical practice and research. A comprehensive QST assessment of 13 sensory parameters may be performed in an hour or less; abbreviated assessments take substantially less time. Although increasingly employed to evaluate sensation, define pain phenotypes, and predict outcomes in research studies and to monitor neurologic deficits in clinical practice, QST remains undervalued and underutilized possibly due to limited familiarity, experience, and understanding within the medical community and a lack of published standards regarding its use. This article is intended as a concise QST overview (with a focus on the use of thermal QST for the detection of small fiber abnormalities often associated with early PN) aimed at improving awareness of the unique role of QST in evaluating sensory function

show abstract

“…Impaired conditioned pain modulation is an important feature of the CS [ 17 ]. Patients with knee OA and altered central pain modulation before surgery have an increased risk of unfavorable outcomes after knee arthroplasty [ [18] , [19] , [20] ]. Likewise, the Central Sensitization Inventory (CSI) is a screening tool developed to identify patients with CS [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Neuropathic-like symptoms and central sensitization related signs and symptoms negatively affect the functional performance of patients with knee osteoarthritis – a cross-sectional study

Goldoni¹,

Bittencourt²,

Santo³

et al. 2023

Osteoarthritis and Cartilage Open

View full text Add to dashboard Cite

Conditioned pain modulation predicts persistent pain after knee replacement surgery

Abstract: Preoperative impaired endogenous analgesia correlates with chronic pain after knee replacement. Preoperative psychological distress is also related with this bad surgical outcome.

Cited by 11 publications

References 30 publications

Quantitative sensory testing as an assessment tool to predict the response to standard pain treatment in knee osteoarthritis: a systematic review and meta-analysis

Quantitative sensory testing as an assessment tool to predict the response to standard pain treatment in knee osteoarthritis: a systematic review and meta-analysis

The Role of Quantitative Sensory Testing in Clinical Medicine and Research

Neuropathic-like symptoms and central sensitization related signs and symptoms negatively affect the functional performance of patients with knee osteoarthritis – a cross-sectional study

Contact Info

Product

Resources

About