Condition of Periodontal Tissues in Children With Congenital Cleat of the Palate and Defect After Uranoplasty

Objectives. Analysis of oral fluid in children with congenital cleft palate and palate defect after uranoplasty. Purpose. To analyze oral fluid in children with congenital cleft palate and palate defect after uranoplasty to determine the levels of pro-inflammatory (IL-1β, IL-6, TNF-α) and anti-inflammatory (IL-4, IL-10) cytokines and secretory immunoglobulin sIgA and evaluate physico-chemical (salivation rate, kinematic viscosity, pH) and biochemical parameters (calcium, magnesium, phosphorus, protein) of mixed saliva. Methodology. The article presents the results of studying the parameters of the oral fluid of 109 children aged 6–12 years with congenital cleft palate and palate defect after uranoplasty and 50 practically healthy children of the same age. Results. Hyperstimulation of pro-inflammatory (IL-1β, IL-6, TNF-α) and anti-inflammatory (IL-4, IL-10) cytokines in the oral fluid and a decrease in the average level of secretory immunoglobulin sIgA. In children with congenital cleft palate and defects remaining after uranoplasty, there was a deviation in the physicochemical and biochemical parameters of the oral fluid, which are manifested by a decrease in the rate of salivation, an increase in its viscosity and a shift in pH to the acid side. In contrast to the group of children without dental pathology, children with cleft palate and defects after uranoplasty showed a decrease in the content of total protein, phosphorus and calcium in the mixed saliva and an increase in the content of magnesium. Conclusions. The obtained laboratory data indicate the presence of a local inflammatory process in the oral cavity and a decrease in local immunological anti-inflammatory factors. This should be taken into account for the development of methods for preoperative sanitation of the oral mucosa in children with congenital cleft palate and a palate defect after uranoplasty at the stage of preparation for reoperation.

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Immunological, Physico-Chemical and Biochemical Parameters of Oral Fluid in Children With Congenital Cleft Palate and Postoperative Palate Defect

Chuykin

Kuchuk

Chuykin

et al. 2022

Actual Problems in Dentistry

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Oral ﬂuid immunological characteristics in children with congenital cleft palate and a postoperative defect

Chuykin

Davletshin

Мочалов

et al. 2022

jour

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Relevance. The lack of anatomical differentiation between the oral cavity and the nasal cavity in children with congenital cleft palate leads to the deterioration of saliva characteristics affecting dental and periodontal disease progression. The oral fluid immunological profile may provide information about the nature of the inflammatory processes and changes in the reaction to the ongoing therapy.Material and methods. The article presents the results of the oral fluid enzyme immunoassay in 109 children aged 6-12 years with congenital cleft palate and a postoperative defect and in 50 practically healthy children of the same age. The study determined the levels of pro-inflammatory (IL-1β, IL-6, TNF-α) and anti-inflammatory (IL-4, IL-10) cytokines and secretory immunoglobulin sIgA in the oral fluid by enzyme-linked immunosorbent assay.Results. The study of children aged 6-12 years with congenital cleft palate and a postoperative defect revealed hyperstimulation of oral fluid pro-inflammatory (IL-1β, IL-6, TNF-α) and anti-inflammatory (IL-4, IL-10) cytokines and a decrease in secretory immunoglobulin sIgA mean level.Conclusion. The oral fluid immunological complexes imbalance in children with congenital cleft palate and a postoperative residual defect is a progressive factor for the development and chronicity of oral inflammatory diseases.The received data evidence the local inflammatory process and a decrease in the oral fluid local protective factors, which one must consider to develop methods for improving the condition of organs and tissues of the oral cavity in children with congenital cleft palate during preparation for surgery to eliminate the residual defect.

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Condition of Periodontal Tissues in Children With Congenital Cleat of the Palate and Defect After Uranoplasty

Cited by 2 publications

References 12 publications

Immunological, Physico-Chemical and Biochemical Parameters of Oral Fluid in Children With Congenital Cleft Palate and Postoperative Palate Defect

Immunological, Physico-Chemical and Biochemical Parameters of Oral Fluid in Children With Congenital Cleft Palate and Postoperative Palate Defect

Oral ﬂuid immunological characteristics in children with congenital cleft palate and a postoperative defect

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