Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes

Lee, Jibak; Ogushi, Sugako; Saitou, Mitinori; Hirano, Takeshi

doi:10.1091/mbc.e11-05-0423

Cited by 64 publications

(83 citation statements)

References 53 publications

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“…3C,D). Such a difference in the subcellular localization of condensins I and II is widely observed among Xenopus egg extracts , mouse oocytes (Lee et al 2011), and even evolutionarily distant organisms, such as the primitive red alga Cyanidioschyzon merolae (Fujiwara et al 2013), implicating its fundamental importance. Although it has been speculated that the differential regulation of the two condensin complexes could help specify their sequential actions (i.e., condensin II first, condensin I later), the physiological significance for such a mechanism remains to be fully understood.…”

Section: Condensin I Associates With Chromosomes In Prometaphase and mentioning

confidence: 97%

Chromosome Dynamics during Mitosis

Hirano

2015

Cold Spring Harb Perspect Biol

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The primary goal of mitosis is to partition duplicated chromosomes into daughter cells. Eukaryotic chromosomes are equipped with two distinct classes of intrinsic machineries, cohesin and condensins, that ensure their faithful segregation during mitosis. Cohesin holds sister chromatids together immediately after their synthesis during S phase until the establishment of bipolar attachments to the mitotic spindle in metaphase. Condensins, on the other hand, attempt to "resolve" sister chromatids by counteracting cohesin. The products of the balancing acts of cohesin and condensins are metaphase chromosomes, in which two rod-shaped chromatids are connected primarily at the centromere. In anaphase, this connection is released by the action of separase that proteolytically cleaves the remaining population of cohesin. Recent studies uncover how this series of events might be mechanistically coupled with each other and intricately regulated by a number of regulatory factors.

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Section: Condensin I Associates With Chromosomes In Prometaphase and mentioning

confidence: 97%

Chromosome Dynamics during Mitosis

Hirano

2015

Cold Spring Harb Perspect Biol

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“…In mouse oocytes at metaphase I, condensin II concentrates within the core of individual sister chromatids, while condensin I is enriched at the centromere (Lee et al, 2011). This is in contrast to the mitotic distribution of these complexes.…”

Section: Chromosomes Are Restructured Extensively In Preparation For mentioning

confidence: 73%

“…Condensin I during mouse (Lee et al, 2011) and C. elegans meiosis (Collette et al, 2011) colocalizes with Aurora B. In the mouse, both condensin I and Aurora B are enriched at the centromere during metaphase I-at the domain important for regulating chromosome orientation.…”

Section: Regulating Chromosome Orientation: a Role For Condensin?mentioning

confidence: 99%

“…In mouse oocytes, injections of SMC2 antibodies (which interfere with the function of both condensin complexes) led to a portion of sister chromatids assuming back-to-back, rather than side-by-side orientation. Anti-CAP-H injection (which interferes with condensin I only) caused disorganized centromeres and chromosome alignment problems (Lee et al, 2011). Condensin function may influence kinetochore structure, or may affect the underlying structure of centromeric chromatin (Bernad et al, 2011;Lee et al, 2011;Ono et al, 2004).…”

Section: Regulating Chromosome Orientation: a Role For Condensin?mentioning

confidence: 99%

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Facing the Correct Pole: The Challenge of Orienting Chromosomes for Meiotic Divisions

Collette¹,

Csankovszki²

2012

Meiosis - Molecular Mechanisms and Cytogenetic Diversity

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“…20 It is possible that after reformation of the nuclear envelope, a small fraction of condensin I remain in the nucleus, contributing to non-mitotic processes. 21 The role of condensin in the regulation of gene expression is elusive. Condensin is involved in the expression regulation of the recombinant DNA and transfer RNA genes in budding and fission yeast and in the organization of polytene chromosomes in Drosophila.…”

Section: Condensinmentioning

confidence: 99%

Structural maintenance of chromosome complexes and bone development: the beginning of a wonderful relationship?

Cohen-Zinder¹,

Karasik

Onn

2013

BoneKEy Reports

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Bone development depends on environmental, nutritional and hormonal factors. Yet, an ordered and timed activation of genes and their associated molecular pathways are central for the growth and development of healthy bones. The correct expression of genes depends on both cis-and trans-regulatory elements. Of these, the elusive role of chromatin ultrastructure is just beginning to become appreciated. Changes in the higher-order structure of chromatin are affecting the expression of genes in response to intrinsic and environmental signals. Cohesin and condensin are members of the structural maintenance of chromosome (SMC) family of protein complexes, which mediate higher-order chromatin structure by tethering distinct regions of chromatin either inter-or intra-molecularly. In recent years, SMCs had been identified for their function in the regulation of gene expression and developmental processes, whereas malfunction of cohesin or condensin has an impact on human health. However, little is known about the specific roles of SMC complexes in bone development and their possible effect on bone health. Here, we review studies that suggest an intimate link between SMCs and bone development, as well as a plausible effect, direct or indirect, on the bone health. We describe genetic syndromes associated with SMCs with distinctive bone phenotypes and identify links between SMCs and bone-related molecular pathways. Future studies of the relationship between SMCs and bone development will reveal new understandings of both the cellular and molecular roles of SMC complexes and provide new insights into the growth and developmental processes in the bone.

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Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes

Cited by 64 publications

References 53 publications

Chromosome Dynamics during Mitosis

Chromosome Dynamics during Mitosis

Facing the Correct Pole: The Challenge of Orienting Chromosomes for Meiotic Divisions

Structural maintenance of chromosome complexes and bone development: the beginning of a wonderful relationship?

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