2021
DOI: 10.14233/ajchem.2021.23016
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Condensation of Lactones with Primary Diamines

Abstract: The condensation of dehydroacetic acid and 4-hydroxy-6-methylpyran-2-one with primary diamine derivatives such as hydrazine, 1,2-diaminoethane and 1,6-diaminohexane yielded bispyrone and bispyridone derivatives has been reported. The condensation of 4-hydroxy-6-methylpyran-2-one with hydrazine in acetonitrile generated another bispyrazole product but in n-butanol, this reaction afforded the bispyridones. The structures of the synthesized bispyrazoles were examined by spectroscopy and X-ray diffraction analysis… Show more

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Cited by 2 publications
(2 citation statements)
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“…12 Given the importance of benzoxazole derivatives in the broad pharmacological classes, 13 the development of synthetic methods for the preparation of the benzoxazole scaffold has been an active area of research. 14 15 Recent trends have focused on the development of greener processes that could reduce the use of toxic reagents or solvents and minimize the production of organic wastes. 16…”
Section: Table 1 Optimization Of the One-pot Benzoxazol...mentioning
confidence: 99%
See 1 more Smart Citation
“…12 Given the importance of benzoxazole derivatives in the broad pharmacological classes, 13 the development of synthetic methods for the preparation of the benzoxazole scaffold has been an active area of research. 14 15 Recent trends have focused on the development of greener processes that could reduce the use of toxic reagents or solvents and minimize the production of organic wastes. 16…”
Section: Table 1 Optimization Of the One-pot Benzoxazol...mentioning
confidence: 99%
“…12 Given the importance of benzoxazole derivatives in the broad pharmacological classes, 13 the development of synthetic methods for the preparation of the benzoxazole scaffold has been an active area of research. 14,15 Recent trends have focused on the development of greener processes that could reduce the use of toxic reagents or solvents and minimize the production of organic wastes. 16 Figure 1 Selected examples of FDA-approved drugs, and the clinical candidate compound 1, bearing a benzoxazole scaffold 6,10,11 Compound 1 was first described as a programmed death-ligand 1 (PD-L1) inhibitor in Phase 2 of a clinical trial conducted by the Incyte Corporation.…”
mentioning
confidence: 99%