Concurrent training remodels the subcutaneous adipose tissue extracellular matrix of people living with HIV: a non-randomized clinical trial

Silva, B.F.; Barletta, Francesco; Pedro, Rafael Evangelista; Batista, M.; Hernandes, Luzmarina; Moraes, Solange Marta Franzói de; Peres, Sidney Barnabé

doi:10.1139/apnm-2021-0284

Cited by 2 publications

(1 citation statement)

References 46 publications

(50 reference statements)

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“…More recently, Silva et al [101] evaluated the effect of concurrent training (12 weeks, 3 times per week) in the ECM of SAT in people living with HIV/AIDS. They observed that concurrent training effectively improved aerobic and strength performances, promoting a decrease in the size heterogeneity of adipocytes and elastic fiber deposition, improving the SAT fibrosis profile.…”

Section: Human Studiesmentioning

confidence: 99%

Adipose Tissue Extracellular Matrix Remodeling in Response to Dietary Patterns and Exercise: Molecular Landscape, Mechanistic Insights, and Therapeutic Approaches

Neto

Durigan

Silva

et al. 2022

Biology

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The extracellular matrix (ECM) is a 3-dimensional network of molecules that play a central role in differentiation, migration, and survival for maintaining normal homeostasis. It seems that ECM remodeling is required for adipose tissue expansion. Despite evidence indicating that ECM is an essential component of tissue physiology, adipose tissue ECM has received limited attention. Hence, there is great interest in approaches to neutralize the harmful effects of ECM enlargement. This review compiles and discusses the current literature on adipose tissue ECM remodeling in response to different dietary patterns and exercise training. High-calorie diets result in substantial adipose tissue ECM remodeling, which in turn could lead to fibrosis (excess deposition of collagens, elastin, and fibronectin), inflammation, and the onset of metabolic dysfunction. However, combining a nutritionally balanced diet with exercise is a remarkable potential strategy for lipolytic activity, preventing rapid ECM expansion in different adipose tissue depots. Despite the distinct exercise modalities (aerobic or resistance exercise) reversing adipose tissue fibrosis in animal models, the beneficial effect on humans remains controversial. Defining molecular pathways and specific mechanisms that mediate the positive effects on adipose tissue, ECM is essential in developing optimized interventions to improve health and clinical outcomes.

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Section: Human Studiesmentioning

confidence: 99%

Adipose Tissue Extracellular Matrix Remodeling in Response to Dietary Patterns and Exercise: Molecular Landscape, Mechanistic Insights, and Therapeutic Approaches

Neto

Durigan

Silva

et al. 2022

Biology

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Assessment of the functional state and level of physical fitness of people with immunodeficiency virus with different levels of T-lymphocytes in the practice of a physical therapist

Orfin

Mazepa

2022

HSR

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Purpose: to assess the functional state of patients with human immunodeficiency virus with different levels of T-lymphocytes for use in the practice of physical therapy. Materials and methods. We examined 24 patients with human immunodeficiency virus at the stage of acquired immunodeficiency syndrome at the outpatient stage of treatment. The patients were divided into 2 groups. Group 1 included 11 patients with CD4+ T-lymphocyte levels <100 cells ml-1, and group 2 included 13 patients with CD4+ T-lymphocyte levels above 150 cells ml-1 (р<0.01). The clinical and anamnestic data, the main anthropometric parameters and physiological indices, the results of carpal dynamometry, the 6-minute walk test, characterizing the functional state of people living with the human immunodeficiency virus, were studied. The results of immunological, virological and biochemical parameters were also studied. Results. Anthropometric indicators: Group 1 – body mass index 48.9±7.4 kg m2-1, waist to hip ratio ratio 0.92±0.17 cm, leg circumference 16.6±0.8 cm; Group 2 – body mass index 23.1±2.8 kg m2 -1, waist to hip ratio ratio 1.14±0.11 cm, leg circumference 15.9±1.4 cm (р>0.05 ). Indicators of physiological indices: Reed - group 1 - 17.3±7.2%, group 2 - 18.3±11.8% (p>0.05); Hobbes - group I 70.9 ± 5.5%, group 2 - 93.6 ± 11.8% (p<0.05), Kerdo - group 1 was 26.6 ± 14.2%, group 2 - 10 .8 ± 14.7% (р<0.05). Index of functional changes group 2 - 2.44±0.2 points, group 2 - 2.59±0.3 points (p>0.05). Dynamometry indicators - group I - 17.5 ± 6.8 kg, group 2 - 28.1 ± 9.4 kg (р>0.05); strength index – group 1 35.3±-9.6%, group 2 40.5±10.4% (р>0.05); 6 min walk test in group 1 - 402.8±40.04 m, group 2 459.7±56.1 m (р<0.05). Indicators of biochemical studies were in reference values ??in patients of both groups. Conclusions. There is a decrease in the functional state and the predominance of catabolic processes in people with human immunodeficiency virus with a significant deficiency of CD4+ T-lymphocytes.

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Concurrent training remodels the subcutaneous adipose tissue extracellular matrix of people living with HIV: a non-randomized clinical trial

Cited by 2 publications

References 46 publications

Adipose Tissue Extracellular Matrix Remodeling in Response to Dietary Patterns and Exercise: Molecular Landscape, Mechanistic Insights, and Therapeutic Approaches

Adipose Tissue Extracellular Matrix Remodeling in Response to Dietary Patterns and Exercise: Molecular Landscape, Mechanistic Insights, and Therapeutic Approaches

Assessment of the functional state and level of physical fitness of people with immunodeficiency virus with different levels of T-lymphocytes in the practice of a physical therapist

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