Concurrent Myocardial and Cerebral Infarctions After Crystal Methamphetamine Use

Azarpira, Negar; Pourjafar, Mehrzad; Delavar-Kasmai, Hosein

doi:10.1097/wnq.0000000000000105

Cited by 4 publications

(1 citation statement)

References 11 publications

(19 reference statements)

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“…This is not psychostimulant‐specific, but relates to injection drug use, the route of administration of half of the psychostimulant group. In addition, psychostimulants may also increase embolic stroke risk through the risk of dilated cardiomyopathy, elevating the risk of arrhythmia, atrial and ventricular mural thrombosis, and thrombo‐embolic stroke . Despite these potential mechanisms, no cases of mycotic, thrombotic, or embolic stroke were observed among psychostimulant users.…”

Section: Discussionmentioning

confidence: 99%

Psychostimulant Use and Fatal Stroke in Young Adults

Darke

Duflou

Kaye

et al. 2019

Journal of Forensic Sciences

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Psychostimulant use is associated with increased stroke risk. To determine the proportion of psychostimulant users among fatal strokes in young adults (15–44 years), all cases were retrieved from the National Coronial Information System (1/1/2009–31/12/2016). A total of 279 cases were identified: hemorrhagic (259), ischemic (8), thrombotic (8), and mycotic (4). Fifty (17.9%) were identified as psychostimulant users. Psychostimulants in blood were detected in 37/45 where toxicology was available, predominantly methamphetamine (32/45). Hemorrhagic strokes in the psychostimulant group were more likely to be intraparenchymal (OR 2.33). Psychostimulant users were less likely to be obese (OR 0.31), but more likely to have a history of tobacco use (OR 2.64). No psychostimulant user had a previous stroke history, was gravid/postpartum, or diagnosed with cerebral vasculitis or endocarditis. The work illustrates the substantial role of psychostimulant use in fatal strokes among young adults. In cases of hemorrhagic stroke among young adults, psychostimulant use should be considered.

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Section: Discussionmentioning

confidence: 99%

Psychostimulant Use and Fatal Stroke in Young Adults

Darke

Duflou

Kaye

et al. 2019

Journal of Forensic Sciences

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The association of amfetamines and cathinones with acute coronary syndrome – a systematic review

Gresnigt

Smits

Haan

et al. 2023

Clinical Toxicology

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Psychostimulant use and the brain

Lappin

Sara

2019

Addiction

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Psychostimulant users are typically young adults. We have conducted a narrative review of neuropsychiatric harms associated with the psychostimulants methamphetamine/amphetamine, cocaine and 3,4‐methylenedioxymethamphetamine (MDMA), focusing on epidemiological factors, common clinical presentations, underlying causal mechanisms and treatment options. The major neuropsychiatric harms of psychostimulant use are stroke, neurocognitive impairment, Parkinson's disease, seizures and psychotic illness. These arise through a combination of acute monoamine release, longer‐term neurotransmitter effects and indirect effects. These effects are moderated by factors in the individual and in the pattern of substance use. Neuropsychiatric harms associated with psychostimulant use can thus lead to severe long‐term impairment.

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Concurrent Myocardial and Cerebral Infarctions After Crystal Methamphetamine Use

Cited by 4 publications

References 11 publications

Psychostimulant Use and Fatal Stroke in Young Adults

Psychostimulant Use and Fatal Stroke in Young Adults

The association of amfetamines and cathinones with acute coronary syndrome – a systematic review

Psychostimulant use and the brain

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