The association of amfetamines and cathinones with acute coronary syndrome – a systematic review

Gresnigt, Femke M J; Smits, Elisabeth; Haan, Chan-Hoon; Riezebos, Robert K.; Franssen, Eric J. F.; Lange, Dylan W. de

doi:10.1080/15563650.2023.2191819

Cited by 3 publications

(2 citation statements)

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“…92,93 Stimulants (e.g., cocaine, amphetamines) have well established CV risks, including HTN, tachycardia, and arrhythmias, and can similarly trigger MI and increase myocardial oxygen demand. [94][95][96] Together, screening for cannabis and stimulants is encouraged to ensure appropriate counseling regarding the increased CV risks and to recommend cessation in high-risk patients.…”

Section: Tobacco Cessation and Substance Usementioning

confidence: 99%

A practical guide for assessing and managing cardiovascular risk during androgen‐deprivation therapy in patients with prostate cancer

Solanki,

Kamrava,

Posadas

et al. 2024

Cancer

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Prostate cancer is the most common malignancy among men worldwide, and androgen‐deprivation therapy (ADT) is a mainstay of treatment. There are observational data demonstrating an increased risk of cardiovascular events in patients who receive ADT, particularly those who have an elevated baseline cardiovascular risk. Because, for most patients with prostate cancer, death is predominantly from noncancer‐related causes, cardiovascular disease and its risk factors should be optimized during cancer treatment. This review provides an overview of the landscape of ADT treatment and serves as a guide for appropriate cardiovascular screening and risk‐mitigation strategies. The authors emphasize the importance of shared communication between the multidisciplinary cancer team and primary care to improve baseline cardiovascular screening and treatment of modifiable risk factors within this higher risk population.

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Section: Tobacco Cessation and Substance Usementioning

confidence: 99%

A practical guide for assessing and managing cardiovascular risk during androgen‐deprivation therapy in patients with prostate cancer

Solanki,

Kamrava,

Posadas

et al. 2024

Cancer

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“…Due to the changing pharmacodynamic profiles, many clinical effects are unknown, although cardiovascular, neurological, and psychopathological symptoms have been reported, including tachycardia, hyperthermia, insomnia, agitation, hallucinations, delusions, and confusion [ 3 ]. Since the use of Khat has been suggested as a risk factor for acute coronary syndrome, it can be expected that synthetic cathinones also cause cardiovascular complications [ 8 ]. With an increase in popularity of these new designer drugs and a variability of pharmacodynamic profiles, physicians face a challenge in recognizing and treating their side effects [ 6 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Cardiotoxicity After Synthetic Cathinone Use; Two Cases, A Case Series and Scoping Review

Groenewegen,

Gresnigt,

Lonkhuyzen

et al. 2024

Cardiovasc Toxicol

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The cardiotoxic effects of synthetic cathinones remain largely unknown. In this study, we present two cases, a case series and a scoping review, to explore synthetic cathinone associated cardiotoxicity. Case 1 involved a 28-year-old male with non-ST-elevation myocardial infarction after ingesting a substance containing 4-methylmethcathinone (4-MMC), 3-methylmethcathinon (3-MMC), and methcathinone. Case 2 involved a 49-year-old male with ventricular fibrillation after 4-methylmethcathinone ingestion, who was diagnosed with severe three-vessel disease. A retrospective analysis was performed on self-reported synthetic cathinone poisonings reported to the Dutch Poisons Information Centre from 2012 to 2022. A total of 222 mono-intoxications with cardiotoxicity were included, mostly involving 3-methylmethcathinon (63%). Often tachycardia, hypertension, palpitations, and chest pain were reported. A comprehensive literature search was performed on PubMed to identify the studies reporting cardiac arrest, myocardial infarction, cardiac inflammation, cardiomyopathy, and life-threatening arrhythmias following synthetic cathinone use. A total of 30 articles reporting 40 cases were included. The reported complications included cardiac arrest (n = 28), ventricular tachycardia (n = 4), supraventricular tachycardia (n = 1), ST-elevation myocardial infarction (n = 2), non-ST-elevation myocardial infarction (n = 2), cardiomyopathy (n = 1), and myocarditis (n = 2). A total of ten different associated synthetic cathinones were identified. Cardiac arrest, myocardial infarction, and ventricular arrhythmias have been reported following the use of synthetic cathinones, underscoring the importance of obtaining a detailed recreational drug use history from patients presenting with syncope, chest pain, or palpitations.

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History of illicit drug use in adults with acute myocardial infarction: Temporal trends from the French national hospital discharge database

Demina,

Cottin,

Chagué

et al. 2023

Archives of Cardiovascular Diseases

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The association of amfetamines and cathinones with acute coronary syndrome – a systematic review

Cited by 3 publications

References 60 publications

A practical guide for assessing and managing cardiovascular risk during androgen‐deprivation therapy in patients with prostate cancer

A practical guide for assessing and managing cardiovascular risk during androgen‐deprivation therapy in patients with prostate cancer

Cardiotoxicity After Synthetic Cathinone Use; Two Cases, A Case Series and Scoping Review

History of illicit drug use in adults with acute myocardial infarction: Temporal trends from the French national hospital discharge database

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