Concurrent Dengue and Malaria in Cayenne Hospital, French Guiana

Carme, Bernard; Matheus, Séverine; Donutil, Gerd; Raulin, Olivia; Nacher, Mathieu; Morvan, Jacques

doi:10.3201/eid1504.080891

Cited by 61 publications

(92 citation statements)

References 13 publications

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“…In a series of 17 confirmed co-infection cases in French Guiana with an epidemiological profile similar to our Manaus, thrombocytopenia was the major complication observed in retrospective data from emergency room patients. 4 Severe anemia was observed in 1 of 11 patients and required red blood cell transfusion. The clinical use of hemoglobin/ hematocrit as a severity marker in concurrent DENV and malaria infection could be tricky and may cause some misinterpretation, considering that both diseases impact red blood cell count through different mechanisms that should be addressed individually.…”

Section: Discussionmentioning

confidence: 99%

“…In French Guiana, a retrospective study with 1,740 patients with acute febrile syndrome identified six confirmed concurrent infection cases, with malaria diagnosis made by thick blood smear and DENV infection diagnosed by positive reverse transcription-polymerase chain reaction (RT-PCR) or viral isolation. 4 In that study, P. vivax and DENV serotype 3 (DENV-3) were responsible for the majority of the co-infections. In Brazil, in the Amazon region, DENV-2 was detected in sera from two patients living in the Eastern Brazilian Amazon that also presented with acute P. vivax infection.…”

Section: Introductionmentioning

confidence: 99%

“…Concomitant infection has become increasingly common caused by the overlap of vectors in endemic areas and increased prevalence of dengue fever described in recent literature. 3,4 For this reason, development of diagnostic and treatment approaches for co-infected patients are desperately needed.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Profile of Concurrent Dengue Fever and Plasmodium vivax Malaria in the Brazilian Amazon: Case Series of 11 Hospitalized Patients

Magalhães¹,

Alexandre²,

Siqueira³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Malaria and dengue fever are the most prevalent vector-borne diseases worldwide. This study aims to describe the clinical profile of patients with molecular diagnosis of concurrent malaria and dengue fever in a tropicalendemic area. Eleven patients with concurrent dengue virus (DENV) and Plasmodium vivax infection are reported. Similar frequencies of DENV-2, DENV-3, and DENV-4 were found, including DENV-3/DENV-4 co-infection. In eight patients, the World Health Organization (WHO) criteria for severe malaria could be fulfilled (jaundice being the most common). Only one patient met severe dengue criteria, but warning signs were present in 10. Syndromic surveillance systems must be ready to identify this condition to avoid misinterpretation of severity attributed to a single disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical Profile of Concurrent Dengue Fever and Plasmodium vivax Malaria in the Brazilian Amazon: Case Series of 11 Hospitalized Patients

Magalhães¹,

Alexandre²,

Siqueira³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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“…Aproximadamente, 200 arbovírus foram isolados no Brasil, e 40 estão associados com doenças em humanos. Quatro destes 40 são considerados ser de importância para a saúde pública no Brasil: vírus da dengue (1)(2)(3)(4), Oropouche, Mayaro e febre amarela. Juntamente com estes vírus, aproximadamente 98% dos casos de malária estão restritos à região da Amazônia Legal.…”

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Concurrent dengue and malaria in the Amazon region

Santana

Lavezzo

Terzian

et al. 2010

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION: The Amazon region has extensive forested areas and natural ecosystems, providing favorable conditions for the existence of innumerous arboviruses. Over 200 arboviruses have been isolated in Brazil and about 40 are associated with human disease. Four out of 40 are considered to be of public health importance in Brazil: Dengue viruses (1-4), Oropouche, Mayaro and Yellow Fever. Along with these viruses, about 98% of the malaria cases are restricted to the Legal Amazon region. METHODS: This study aimed to investigate the presence of arboviruses in 111 clinical serum samples from patients living in Novo Repartimento (Pará), Plácido de Castro (Acre), Porto Velho (Rondônia) and Oiapoque (Amapá). The viral RNA was extracted and RT-PCR was performed followed by a Multiplex-Nested-PCR, using Flavivirus, Alphavirus and Orthobunyavirus generic and species-specific primers. RESULTS: Dengue virus serotype 2 was detected in two patients living in Novo Repartimento (Pará) that also presented active Plasmodium vivax infection. CONCLUSIONS: Despite scant data, this situation is likely to occur more frequently than detected in the Amazon region. Finally, it is important to remember that both diseases have similar clinical findings, thus the diagnosis could be made concomitantly for dengue and malaria in patients living or returning from areas where both diseases are endemic or during dengue outbreaks.

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“…As illustrated by articles in this issue about adiaspiromycosis (2), malaria (3,4), dengue (4), Chagas disease (5), Kaposi sarcoma-associated herpesvirus (6), suspected Brazilian purpuric fever (7), and other infections, new diseases continue to emerge and old ones continue to undergo epidemiologic change throughout the vast Amazon River basin.…”

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confidence: 99%

The Status of Infectious Disease in the Amazon Region

Tauil¹

2009

Emerg. Infect. Dis.

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Concurrent Dengue and Malaria in Cayenne Hospital, French Guiana

Cited by 61 publications

References 13 publications

Clinical Profile of Concurrent Dengue Fever and Plasmodium vivax Malaria in the Brazilian Amazon: Case Series of 11 Hospitalized Patients

Clinical Profile of Concurrent Dengue Fever and Plasmodium vivax Malaria in the Brazilian Amazon: Case Series of 11 Hospitalized Patients

Concurrent dengue and malaria in the Amazon region

The Status of Infectious Disease in the Amazon Region

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