Concurrent Chemoradiotherapy Improves Survival in Patients With Hypopharyngeal Cancer

Abstract

Purpose To retrospectively review our institutional experience with hypopharyngeal carcinoma with respect to treatment modality. Methods and Materials A total of 70 patients with hypopharyngeal cancer treated between 1999 and 2009 were analyzed for functional and survival outcomes. The treatments included surgery alone (n = 5), surgery followed by radiotherapy (RT) (n = 3), surgery followed by chemoradiotherapy (CRT) (n = 13), RT alone (n = 2), CRT alone (n = 22), induction chemotherapy followed by RT (n = 3), and induction chemotherapy followed by CRT (n = 22). Results The median follow-up was 18 months. The median overall survival and disease-free survival for all patients was 28.3 and 17.6 months, respectively. The 1- and 2-year local control rate for all patients was 87.1% and 80%. CRT, given either as primary therapy or in the adjuvant setting, improved overall survival and disease-free survival compared with patients not receiving CRT. The median overall survival and disease-free survival for patients treated with CRT was 36.7 and 17.6 months vs. 14.0 and 8.0 months, respectively (p <.01). Of the patients initially treated with an organ-preserving approach, 4 (8.2%) required salvage laryngectomy for local recurrence or persistent disease; 8 (16.3%) and 12 (24.5%) patients were dependent on a percutaneous gastrostomy and tracheostomy tube, respectively. The 2-year laryngoesophageal dysfunction-free survival rate for patients treated with an organ-preserving approach was estimated at 31.7%. Conclusions Concurrent CRT improves survival in patients with hypopharyngeal cancer. CRT given with conventional radiation techniques yields poor functional outcomes, and future efforts should be directed at determining the feasibility of pharyngeal-sparing intensity-modulated radiotherapy in patients with hypopharyngeal tumors.

Did the Addition of Concomitant Chemotherapy to Radiotherapy Improve Outcomes in Hypopharyngeal Cancer? A Population-Based Study

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Application of xenogenic acellular dermal matrix in reconstruction of oncological hypopharyngeal defects

“…Reports describing the 3-year survival rate of hypopharyngeal cancer that reconstruct by flap after resection are scarce. Paximadis reported a total of 70 patients with hypopharyngeal cancer treated by surgery, radiotherapy, chemotherapy or combined between 1999 and 2009 [17]. The 3-year survival rate for stage I-IVa (resectable) patients was 60 %.…”

Intratumoral lymphatic vessel density as a predictor of progression‐free and overall survival in locally advanced laryngeal/hypopharyngeal cancer

“…The follow‐up for this group of patients is similar to that described previously . Briefly, upon completion of therapy, patients were seen on a monthly basis for the first year, every 2 to 3 months in the second year, every 3 to 6 months in years 3 through 5, and yearly thereafter.…”

“…The follow-up for this group of patients is similar to that described previously. 19 Briefly, upon completion of therapy, patients were seen on a monthly basis for the first year, every 2 to 3 months in the second year, every 3 to 6 months in years 3 through 5, and yearly thereafter. Follow-up evaluations consisted of a comprehensive medical history and physical examination, which included flexible laryngoscopy.…”