Application of xenogenic acellular dermal matrix in reconstruction of oncological hypopharyngeal defects

Li, Ping; Li, Shisheng; Yang, Xinming; Tang, Qinglai; Wang, Shuang

doi:10.1007/s00405-016-4088-0

Cited by 7 publications

(7 citation statements)

References 19 publications

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“…This was also consistent with the results of other previous studies on ADM repair. [ 27 , 28 ] The reason for this might be that the ADM retains collagen fibers, elastic fibers, and reticular fibers in the original dermis, forming the material basis for soft texture, lighter contraction, and lighter color change after the survival of ADM graft. [ 29 ]…”

Section: Discussionmentioning

confidence: 99%

“…Obviously, the use of xeno-ADM saves time and reduces blood loss, which is also supported by the conclusions of other previous studies. [ 27 , 30 ] In this study, the survival and recurrence rates within 1 year after operation were evaluated, and the results revealed that no patients had local recurrence in both groups. We believed that a good and sufficient repair material was conducive for adequate resection of lesions and ensure adequate safety of margins during operation.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of xenogeneic acellular dermal matrix and skin grafts in reconstruction of postoperative defects of hypopharyngeal cancer

Zang

Feng²,

Yang³

et al. 2020

Medicine

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Successful reconstruction after tumor resection facilitates rapid recovery and retention of good quality of life, and this is important for a successful operation. This study aimed to analyze and compare the application and efficacy of xenogeneic acellular dermal matrix (xeno-ADM) and abdominal skin graft in hypopharynx reconstruction. This is a retrospective cohort study that included 25 patients with posterior hypopharyngeal wall cancer who underwent partial hypopharyngectomy with laryngeal preservation. The patients were divided into 2 groups according to the repair materials used. Eleven patients were treated with xeno-ADM, and 14 patients with abdominal skin grafts for repairing hypopharyngeal mucosal defects. The intraoperative data, postoperative recovery time of eating function, graft contraction, infection and pharyngeal fistula rate, and 1-year survival rate of the 2 groups were analyzed and compared. Compared with skin grafts group (23.1 ± 5.8 days), the recovery time of eating function in xeno-ADM group was shorter (17.3 ± 6.4 days), ( P = .026). Also the number of postoperative hospitalization days were less in the xeno-ADM group (18.5 ± 6.7 days) than in the skin grafts group (24.1 ± 5.6 days) ( P = .035). Besides, no significant differences were observed in other comparisons between the 2 groups. Also no obvious rejection and severe graft contraction were observed in both the groups. All patients were successfully decannulated. Both xeno-ADM and abdominal skin grafts demonstrated good effects in the reconstruction of hypopharynx, but the recovery time of eating function in patients with xeno-ADM was faster, which may be due to rapid epithelialization. In addition, it avoids trauma of donor sites.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of xenogeneic acellular dermal matrix and skin grafts in reconstruction of postoperative defects of hypopharyngeal cancer

Zang

Feng²,

Yang³

et al. 2020

Medicine

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“…19 The ADM has been used in thyroid cancer, laryngeal cancer, hypopharyngeal cancer, and tympanic membrane repair. 7,18,20,21 The advanced spatial structure of type I collagen is retained in the ADM, and the microstructure of collagen is more complete. Three-dimensional structures can provide excellent scaffolds for cell crawling, and the presence of microstructure promotes cell adhesion.…”

Section: Discussionmentioning

confidence: 99%

Acellular dermal matrix contributes to epithelialization in patients with chronic sinusitis

Zhong

et al. 2019

J Biomater Appl

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Background Nasal endoscopic surgery is widely used for nasal diseases, including sinusitis and tumors. However, scar hyperplasia, nasal irritation, scab, and nasal obstruction delay nasal mucosal recovery, with prolonged cleaning exacerbating the patient's financial burden. Here, we presented a novel approach for the treatment of nasal mucosal defects, termed acellular dermal matrix. Methods A total of 31 patients with bilateral chronic sinusitis (maxillary sinusitis and ethmoid sinusitis) underwent nasal surgery and nasal mucosal repair in September–October 2016. We divided the nasal cavities of each patient into control and acellular dermal matrix groups, randomly selected one side for nasal mucosal repair by surgery. A suitable acellular dermal matrix size was selected according to the defect in each patient. After pruning, the acellular dermal matrix was placed on the wound surface and filled with gelatin sponge. All patients were followed up for 14 weeks to compare nasal mucosal epithelialization between the control and acellular dermal matrix groups. Results：No obvious complications and adverse reactions were observed after nasal surgery. Lund-Kennedy scores in the acellular dermal matrix group were significantly decreased compared with the control group at 8 (0 (0, 1) vs. 2 (2, 4); P<0.05) weeks. Epithelialization time of eight weeks in the acellular dermal matrix groups was significantly decreased than the control group of 14 weeks. Conclusion Acellular dermal matrix provides a growth framework for the healthy mucosa on the wounded surface and reduces postoperative epithelialization time.

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“…17 The simple native biomaterials such as allogeneic acellular dermal matrix patches are only used to repair a small range of defects. [18][19][20] In our experiment, the complex full-thickness ECM with vascular pedicle scaffold was prepared to solve the large scale of hypopharyngeal defects and has not been reported so far.…”

Section: Introductionmentioning

confidence: 99%

Development of a decellularized hypopharynx with vascular pedicle scaffold for use in reconstructing hypopharynx

Hou

et al. 2022

Artificial Organs

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Background:Hypopharynx reconstruction after hypopharyngectomy is still a great challenge. Perfusion decellularization is for extracellular matrix (ECM) scaffolding and had been used in organ reconstruction. Our study aimed to prepare an acellular, natural, three-dimensional (3D) biological hypopharynx with vascular pedicle scaffold as the substitute materials to reconstruct hypopharynx.Result:Scanning electron microscope (SEM) and immuno showed that the decellularized hypopharynx with vascular pedicle scaffold retained intact native anatomical ECM structure. Myoblasts were observed on the recellularized scaffolds with bone marrow mesenchyml stem cells (BMSCs) induced by 5-azacytidine implanted in the rabbit greater omentum by immunohistochemical analysis. Conclusion:the decellularized hypopharynx with vascular pedicle scaffold prepared by detergent perfusion in our study has an potential to be an alternative material to pharynx reconstruction.

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Application of xenogenic acellular dermal matrix in reconstruction of oncological hypopharyngeal defects

Cited by 7 publications

References 19 publications

Comparison of xenogeneic acellular dermal matrix and skin grafts in reconstruction of postoperative defects of hypopharyngeal cancer

Comparison of xenogeneic acellular dermal matrix and skin grafts in reconstruction of postoperative defects of hypopharyngeal cancer

Acellular dermal matrix contributes to epithelialization in patients with chronic sinusitis

Development of a decellularized hypopharynx with vascular pedicle scaffold for use in reconstructing hypopharynx

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