Concurrent Axial and Appendicular Osteoporosis

Smith, Richmond W.; Frame, Boy

doi:10.1056/nejm196507082730203

Cited by 82 publications

(31 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our control series had healthier bones than the general population, because all known bone-affecting diseases and drugs were used a s criteria for exclusion. We assume that the controls of Several investigations show that changes in the peripheral bones are similar to those in axial bones (Smith & Frame 1965, Nordin et al 1970, Siegelman 1970. A longitudinal study is needed to determine the correlations between bone mineral densities and osteoarthrosis, and the possible effects of physical activity, over-activity of growth hormone etc.…”

Section: Discussionmentioning

confidence: 94%

Bone Mineral in Patients with Osteoarthrosis of the Hip

Alhava¹,

Kettunen²,

Karjalainen³

1975

Acta Orthopaedica Scandinavica

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 94%

Bone Mineral in Patients with Osteoarthrosis of the Hip

Alhava¹,

Kettunen²,

Karjalainen³

1975

Acta Orthopaedica Scandinavica

View full text Add to dashboard Cite

“…A retrospective epidemiological study revealed a positive correlation between calcium deficiency and osteoporosis in both osteoporosis patients and healthy individuals 21) . In this study, experiments were conducted in a rat model with the aim of evaluating changes in bone quality over time caused by oestrogen deficiency (ovariectomy) with and without mineral deficiency.…”

Section: Discussionmentioning

confidence: 99%

Quantitative and Qualitative Analyses of Low-mineral-diet Ovariectomised Rat Femora Using Microscopic Computed Tomography

Suzuki¹,

Tanaka²,

Tanimoto³

et al. 2011

J. Hard Tissue Biology.

View full text Add to dashboard Cite

The aim of this study was to monitor changes in bone density and bone quality (microarchitecture) in the femoral epiphyseal region in rats with bone loss induced by oestrogen deficiency and accelerated by mineral deficiency. Forty-eight Wistar rats were divided into 3 groups (n = 16 per group): Group 1, sham-operated rats on a normal diet; Group 2, ovariectomised rats on a normal diet; and Group 3, ovariectomised rats on a mineraldeficient diet. Observations were conducted 4, 8, 16, and 24 weeks after the operation (sham or ovariectomy), while the rats were on their respective diets. Microscopic computed tomography of the femoral epiphyseal region was used to generate 3-dimensional bone density distribution maps, and to compute bone density values. Densities of cortical and cancellous bone in Groups 2 and 3 were significantly less than densities in Group 1, and densities in Group 3 were significantly less than densities in Group 2 at nearly every post-operative time interval.This study demonstrated that: a) ovariectomy in rats induces bone loss; b) a mineral-deficient diet accelerates bone loss that has been induced by oestrogen deficiency; and c) 3-dimensional bone density distribution maps may be useful in diagnosing osteoporosis and other diseases causing bone loss. Microscopic computed tomography is a powerful analytical tool for measuring spatial variations in bone density, and temporal changes in the patterns of 3-dimensional bone density distribution maps.

show abstract

“…Because bone measures taken at the three locations in our sample are highly correlated (r = 0.78, 0.80, 0.84), we present only the results based on measurements taken at minimum shaft width. Smith [58,59] has shown that in growing bones, measurements taken at the location of minimum shaft width are as reliable as those taken at mid-shaft, and are homologous throughout growth. All measurements were made by a single individual.…”

Section: Bone Measurementsmentioning

confidence: 99%

Quantitative genetics of cortical bone mass in healthy 10-year-old children from the Fels Longitudinal Study

Duren

Sherwood

Choh

et al. 2007

Bone

View full text Add to dashboard Cite

The genetic influences on bone mass likely change throughout the life span, but most genetic studies of bone mass regulation have focused on adults. There is, however, a growing awareness of the importance of genes influencing the acquisition of bone mass during childhood on lifelong bone health. The present investigation examines genetic influences on childhood bone mass by estimating the residual heritabilities of different measures of second metacarpal bone mass in a sample of 600 10-year-old participants from 144 families in the Fels Longitudinal Study. Bivariate quantitative genetic analyses were conducted to estimate genetic correlations between cortical bone mass measures, and measures of bone growth and development. Using a maximum likelihood-based variance components method for pedigree data, we found a residual heritability estimate of 0.71 for second metacarpal cortical index. Residual heritability estimates for individual measures of cortical bone (e.g., lateral cortical thickness, medial cortical thickness) ranged from 0.47 to 0.58, at this prepubertal childhood age. Low genetic correlations were found between cortical bone measures and both bone length and skeletal age. However, after Bonferonni adjustment for multiple testing, ρ G was not significantly different from 0 for any of these pairs of traits. Results of this investigation provide evidence of significant genetic control over bone mass largely independent of maturation while bones are actively growing and before rapid accrual of bone that typically occurs during puberty.

show abstract

Concurrent Axial and Appendicular Osteoporosis

Cited by 82 publications

References 13 publications

Bone Mineral in Patients with Osteoarthrosis of the Hip

Bone Mineral in Patients with Osteoarthrosis of the Hip

Quantitative and Qualitative Analyses of Low-mineral-diet Ovariectomised Rat Femora Using Microscopic Computed Tomography

Quantitative genetics of cortical bone mass in healthy 10-year-old children from the Fels Longitudinal Study

Contact Info

Product

Resources

About