Bone Mineral in Patients with Osteoarthrosis of the Hip

Alhava, E; Kettunen, K; Karjalainen, P

doi:10.3109/17453677508989256

Cited by 22 publications

(11 citation statements)

References 9 publications

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“…An inverse relationship has been found in most of them (2,6,7,19,20,22,24). In a few studies, however, no increase in bone density was seen in patients with hip OA (21,23,25). Earlier studies had small numbers (20,21) of hospitalized patients with total hip replacement as cases of OA (2,(19)(20)(21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

“…In a few studies, however, no increase in bone density was seen in patients with hip OA (21,23,25). Earlier studies had small numbers (20,21) of hospitalized patients with total hip replacement as cases of OA (2,(19)(20)(21)(22)(23). Such patients have symptomatic OA and are likely to have restricted mobility, which potentially affects bone mass.…”

Section: Discussionmentioning

confidence: 99%

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A cotwin control study of the relationship between hip osteoarthritis and bone mineral density

Antoniades

Macgregor

Matson

et al. 2000

Arthritis & Rheumatism

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Objective. Previous case-control studies have shown various degrees of inverse relationship between osteoarthritis (OA) and osteoporosis (OP). The aim of this study was to examine the relationship between radiographic hip OA and bone mineral density (BMD) at the affected and contralateral hips, as well as at more distal sites. We also explored the possibility that this association might be confounded by genetic factors. Methods. Using the discordant twin model to reduce selection bias and adjust for genetic factors, plain pelvic radiographs of white female twins aged >40 years, from the St. Thomas' UK Adult Twin Register, were assessed for radiographic features of hip OA. Overall OA was classified using a 6-point global grading system (Croft). Osteophytes (OPH) and joint space narrowing (JSN) were also examined separately. BMD was measured by dual x-ray absorptiometry at the left hip, lumbar spine, and total body. The association of OA with BMD was assessed using conditional logistic regression. Adjustments were made for body mass index, lifetime physical activity, menopausal status, use of estrogen, and smoking. Results. The analysis included a total of 1,148 women comprising 160 monozygotic and 414 dizygotic twin pairs. The median age of the twins was 53 years (range 40-70). The crude and adjusted odds ratios and 95% confidence intervals for having radiographic features of hip OA were 1.63 (1.06, 2.50) and 1.80 (1.05, 3.12), respectively, per unit difference in standardized BMD of the ipsilateral femoral neck. The presence of OPH, but not JSN, was associated with higher BMD. Twins with hip OPH had 3.5% higher femoral neck BMD than their unaffected cotwins. No clear association was found between hip OA and BMD at the contralateral site, lumbar spine, or total body. Conclusion. This twin study confirms the existence of an inverse relationship between OA and OP at the hip. However, the relationship was localized to the OA-affected hip. The generalized and greater increase in BMD in osteoarthritic subjects seen in previous studies of unrelated populations is therefore likely to be due, in part, to genetic factors shared by hip OA and high bone mass. It also suggests that local changes in bone density may be a component of the disease process in hip OA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A cotwin control study of the relationship between hip osteoarthritis and bone mineral density

Antoniades

Macgregor

Matson

et al. 2000

Arthritis & Rheumatism

View full text Add to dashboard Cite

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“…Then Carlsson et al 20 noticed that the BMD of the trabecular but not the cortical bone was increased in patients with OA. In addition, Alhava et al 17 observed that the BMD of forearm bones, or the second metacarpals, was not increased in patients with hip OA compared with controls. In patients with primary generalised OA, no significant correlation has been noticed between BMD and OA.…”

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confidence: 96%

Increased bone mineral content and bone size in the femoral neck of men with hip osteoarthritis

Arokoski

2002

Annals of the Rheumatic Diseases

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Objectives: Even though clinical findings support the idea that hip osteoarthritis (OA) is associated with increased bone mineral density (BMD), the subject remains controversial. This study was therefore initiated to investigate the relation between the severity of hip OA and femoral and calcaneal BMD. Methods: On the basis of the American College of Rheumatology criteria on classification of OA of the hip, 27 men (aged 47-64 years) with unilateral or bilateral hip OA and 30 age matched randomly selected healthy men were studied. Plain radiographs were graded using Li's scale from 0 (no OA) to 4 (severe OA). According to the side of the highest radiographic score from the patients with clinical hip OA, 29.6% had grade 1, 29.6% grade 2, and 40.8% grade 3 OA. Bone mineral content (BMC), areal BMD (BMD areal ), and bone dimensions (area and width) were measured by dual x ray absorptiometry at the proximal femur. BMD areal of the calcaneus was measured from the central area of the bone. Volumetric measurements from magnetic resonance images of the femoral neck were used to create a BMD measure that was corrected for the femoral neck volume (BMD mri ). Results: There were no differences in weight, or body mass index between the study groups. There were no significant BMD areal differences in any of the subregions of the proximal femur (femoral neck and trochanter) or calcaneus between the OA and control groups. Neither did the BMD mri of the femoral neck differ between the groups. However, the BMC of the femoral neck was 18% higher (p<0.01) in patients with OA than in controls. Similarly femoral neck bone width and volume were 9% and 18% respectively higher (p<0.001) in patients with OA. Conclusions:The results suggest that men with hip OA have larger femoral neck size and consequently higher BMC than healthy controls matched for age and sex. There is no significant difference in femoral neck BMD (BMD areal or BMD mri ) between the groups. Furthermore, increased BMD areal was not found in the peripheral skeleton. These findings suggest that hip OA is not associated with an increase in BMD areal in the femoral neck. However, the increase in BMC and bone size in patients with hip OA may play a part in the pathogenesis of the disease.

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“…Osteoporosis and osteoarthritis commonly affect the elderly and there have been many studies concerning the relationship between the two, especially in patients with osteoarthritis of the hip [1][2][3][4][5][6][7][8][9][10] and with more generalised degenerative changes. 6,[11][12][13][14] They rarely occur together and it has been suggested that there may be an inverse relationship between them.…”

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confidence: 99%

The influence of osteoporosis on varus osteoarthritis of the knee

Terauchi

Shirakura

Katayama

et al. 1998

The Journal of Bone and Joint Surgery. British volume

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W e studied 37 patients with varus osteoarthritis of the knee to determine the influence of the bone mineral density (BMD) on the varus deformity. There were 15 men (21 knees) and 22 women (38 knees). The mean age of the men was 69 years and of the women 68 years. BMD was measured in the L1-L4 spinal region using dual X-ray absorptiometry. In the women a low level of BMD was associated with varus deformity originating at the proximal tibia, but a high level was predominantly linked with deformity originating in the joint space. Similar findings were obtained in the men. Our results suggest that a low BMD predisposes to trabecular microfractures and consequently increased stress on the articular cartilage. A low BMD does not preclude osteoarthritic change in the knee.

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Bone Mineral in Patients with Osteoarthrosis of the Hip

Cited by 22 publications

References 9 publications

A cotwin control study of the relationship between hip osteoarthritis and bone mineral density

A cotwin control study of the relationship between hip osteoarthritis and bone mineral density

Increased bone mineral content and bone size in the femoral neck of men with hip osteoarthritis

The influence of osteoporosis on varus osteoarthritis of the knee

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