Concordance between Subjective and Objective Memory Impairment in Volunteer Subjects

Alegret, Montserrat; Rodríguez, Octavio; Espinosa, Ana; Ortega, Gemma; Sanabria, Ángela; Valero, Sergi; Hernández, Isabel; Rosende-Roca, Maiteé; Vargas, Liliana; Abdelnour, Carla; Mauleón, Ana; Gailhajanet, Anna; Martín, E.; Tárraga, Lluís; Rentz, Dorene M.; Amariglio, Rebecca E.; Ruiz, Agustín; Boada, Merçé

doi:10.3233/jad-150594

Cited by 34 publications

(43 citation statements)

References 49 publications

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“…In contrast, SCD is not significantly associated with performance on objective tests of cognition when adjusting for demographics and symptoms of depression. These results in Hispanic older adults replicate previous findings in non-Hispanic Whites [8, 9] and support the conclusion that SCD is more indicative of symptoms of depression than concurrent cognitive function in older Hispanics who report cognitive complaints to their primary care physician [5, 19–21]. The findings are also consistent with previous studies that have shown that subjective memory complaints are associated with sub-syndromal or sub-clinical depression in community-dwelling older adults [19, 22].…”

Section: Discussionsupporting

confidence: 87%

“…Third, we cannot address the value that SCD may hold in predicting future cognitive decline in this sample due to the cross-sectional nature of this study. Several research studies have observed minimal cross-sectional associations between SCD reporting and cognitive performance [5, 8, 9, 24], while others have consistently found associations between SCD reporting and biomarkers of Alzheimer’s disease and future cognitive decline [25, 31–33], although this is not always the case [34, 35]. Our current results replicate and extend previous cross-sectional findings in non-Hispanic Whites to a group of Hispanic older adults; however, additional research continues to be needed to determine the value of SCD in predicting future cognitive changes in older Hispanics.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence suggests, however, that SCD is not strongly correlated with concurrent level of cognitive ability as measured by objective cognitive tests. Rather, SCD is associated with the presence and severity of symptoms of depression in both community-dwelling and clinic-based samples of older adults [5–9]. Additional factors such as personality traits and cultural background might also be related to SCD, but little research has been done outside of non-Hispanic White older adult cohorts [5–7].…”

Section: Introductionmentioning

confidence: 99%

“…Rather, SCD is associated with the presence and severity of symptoms of depression in both community-dwelling and clinic-based samples of older adults [5–9]. Additional factors such as personality traits and cultural background might also be related to SCD, but little research has been done outside of non-Hispanic White older adult cohorts [5–7]. The Subjective Cognitive Decline Initiative (SCD-I) Working Group recently published recommendations for the implementation of SCD criteria in research studies and mentioned that “further work is needed to determine whether SCD may manifest differently in different racial or ethnic groups” [10].…”

Section: Introductionmentioning

confidence: 99%

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Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Zlatar

Muniz

Espinoza

et al. 2018

JAD

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Subjective cognitive decline (SCD) is common in older adults and may be an early marker of future cognitive decline. Research suggest that SCD is more closely related to concurrent symptoms of depression than to objective cognitive performance in non-Hispanic Whites, but it is unknown whether the associations of SCD, cognition, and depression manifest differently in Hispanic older adults. We examined if SCD is associated with objective cognitive performance or with depression symptoms in 145 Hispanic individuals ages 60 or older referred by community health clinics for screening of cognitive complaints. All participants lived near the U.S.-Mexico border, spoke Spanish only, or were Spanish-English bilingual. Memory-only and global cognitive composites were created from scores on Spanish versions of several neuropsychological tests. The Geriatric Depression Scale (GDS) and a five-item SCD questionnaire developed by our group were also completed. Multiple regression analyses showed no significant associations between SCD and memory or global cognitive composite scores after adjusting for age, sex, education, and GDS score. In contrast, there was a significant association between GDS and SCD after adjusting for age, sex, education, global and memory composite scores. Findings suggest that SCD does not accurately reflect current cognitive status in older Hispanics who present to their primary care physician with cognitive complaints. Clinicians should interpret SCD in this population within the context of information about symptoms of depression. Longitudinal research is needed in older Hispanics to better characterize SCD in this population and to determine if it can predict future cognitive decline.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Zlatar

Muniz

Espinoza

et al. 2018

JAD

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“…We used the Spanish version of FNAME (the S-FNAME) to determine whether it was also associated with Aβ burden in subjects with SCD as demonstrated with its original version (the FNAME) 15 . In accordance with previous results 16,17 , the cognitive outcomes most closely related to the face-name associative memory scores of S-FNAME were episodic memory-sensitive NBACE variables (learning, long-term memory and recognition task of the Word List Learning test from WMS-III). These findings reinforce the results obtained in our previous studies using the WMS-III 16 and with the original validation of FNAME, whose scores were highly correlated with those measured by another recognized episodic memory test, the 6-Trial Selective Reminding Test (SRT) 19 .…”

Section: Discussionsupporting

confidence: 91%

[O1–13–06]: The Spanish Version of Face‐name Associative Memory Exam (S‐fname) Performance Is Related to Amyloid Burden in Subjective Cognitive Decline

Alegret

Sanabria

Rodríguez-Gómez

et al. 2017

Alzheimer's & Dementia

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The Face-Name Associative Memory Exam (FNAME) is a paired associative memory test created to detect memory deficits in individuals with preclinical Alzheimer's disease (AD). Worse performance on FNAME in cognitively healthy individuals were found related to higher amyloid beta (Aβ) burden measured with Positron-Emission-Tomography using 11 C-PiB (PiB-PET). We previously reported normative data of a Spanish version of FNAME (S-FNAME) in cognitively healthy Spanish-speaking subjects. The aim of the present study was to determine whether performance on S-FNAME was associated with Aβ burden in subjective cognitive decline (SCD) individuals. 200 SCD subjects received neurological and neuropsychological assessments, including the S-FNAME and the Word List task from the Wechsler-Memory-Scale-III (WMS-III). Moreover, they received an MRI and (18)F-Florbetaben Positron-Emission-Tomography (FBB-PET) to measure Aβ burden. Three cognitive factor composites were derived for the episodic memory measures (face-name [SFN-N], face-occupation [SFN-O] and WMS-III) to determine whether episodic memory performance was related to Aβ deposition. Higher global Aβ deposition was significantly related to worse performance on SFN-N but not with SFN-O or WMS-III Composite. Moreover, worse SFN-N performance was significantly related to higher Aβ deposition in bilateral Posterior Cingulate Cortex. The S-FNAME may be a promising neuropsychological tool for detecting SCD individuals with preclinical AD.Alzheimer's disease (AD) is a major health problem with an estimated 50 million people worldwide living with dementia 1,2 with 33% of clinically normal older individuals having the underlying pathology of AD. With the advent of AD prevention trials, there is a growing interest in developing new diagnostic tools to detect the first symptoms of AD that may precede mild cognitive impairment (MCI).Subjective cognitive decline (SCD) has been proposed as a risk factor for progression to AD dementia 3,4 . It refers to the perception of memory or other cognitive problems without impairment on standardized cognitive tests. Longitudinal studies have demonstrated that cognitively healthy individuals with SCD have a [9][10][11][12] . Preclinical AD, by definition, is the identification of those clinically normal individuals with AD pathological burden. However, preclinical AD cannot be diagnosed with current standard neuropsychological tools and its diagnosis relies on the positivity of the different biomarkers of AD 13 . For this reason, there is an increasing interest in developing neuropsychological tools capable of identifying the subtle cognitive deficits present in the preclinical stage of AD 14 . The Face-Name Associative Memory Exam (FNAME), developed by Rentz and colleagues 15 , is a highly demanding face-name associative memory exam, but easy to administer and found useful for detecting evidence of amyloid-β (Aβ) burden related memory impairment in cognitively healthy individuals. The authors reported that lower performance on the FNAME were rela...

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Diagnostic Accuracy of Memory Measures in Alzheimer’s Dementia and Mild Cognitive Impairment: a Systematic Review and Meta-Analysis

et al. 2017

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With an increasing focus on biomarkers in dementia research, illustrating the role of neuropsychological assessment in detecting mild cognitive impairment (MCI) and Alzheimer’s dementia (AD) is important. This systematic review and meta-analysis, conducted in accordance with PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) standards, summarizes the sensitivity and specificity of memory measures in individuals with MCI and AD. Both meta-analytic and qualitative examination of AD versus healthy control (HC) studies (n = 47) revealed generally high sensitivity and specificity (≥ 80% for AD comparisons) for measures of immediate (sensitivity = 87%, specificity = 88%) and delayed memory (sensitivity = 89%, specificity = 89%), especially those involving word-list recall. Examination of MCI versus HC studies (n = 38) revealed generally lower diagnostic accuracy for both immediate (sensitivity = 72%, specificity = 81%) and delayed memory (sensitivity = 75%, specificity = 81%). Measures that differentiated AD from other conditions (n = 10 studies) yielded mixed results, with generally high sensitivity in the context of low or variable specificity. Results confirm that memory measures have high diagnostic accuracy for identification of AD, are promising but require further refinement for identification of MCI, and provide support for ongoing investigation of neuropsychological assessment as a cognitive biomarker of preclinical AD. Emphasizing diagnostic test accuracy statistics over null hypothesis testing in future studies will promote the ongoing use of neuropsychological tests as Alzheimer’s disease research and clinical criteria increasingly rely upon cerebrospinal fluid (CSF) and neuroimaging biomarkers.

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Concordance between Subjective and Objective Memory Impairment in Volunteer Subjects

Cited by 34 publications

References 49 publications

Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

[O1–13–06]: The Spanish Version of Face‐name Associative Memory Exam (S‐fname) Performance Is Related to Amyloid Burden in Subjective Cognitive Decline

Diagnostic Accuracy of Memory Measures in Alzheimer’s Dementia and Mild Cognitive Impairment: a Systematic Review and Meta-Analysis

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