Concomitant thyroid Malt lymphoma and papillary thyroid carcinoma

Melo, Giulianno Molina de; Sguilar, Danilo Anunciatto; Petiti, Cyntia Moniz Figueira; Eichstaedt, André Gustavo Gumz; Caiado, Rogério Ramos; Souza, Ricardo Antenor de Souza e

doi:10.1590/s0004-27302010000400013

Cited by 27 publications

(23 citation statements)

References 17 publications

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“…The other 30% comprises mucosa associated lymphoid tissue (MALT) lymphomas, which are indolent in most cases and have a better response to systemic treatment (5,6). Some cases of association between HT and both PTC and MALT lymphomas have been described (7)(8)(9), while a DLBCL in the context of coexisting HT and PTC is very rare (10).…”

Section: Introductionmentioning

confidence: 99%

Coexistence of diffuse large B-cell lymphoma and papillary thyroid carcinoma in a patient affected by Hashimoto's thyroiditis

Trovato

Giuffrida

Seminara³

et al. 2017

Arch. Endocrinol. Metab.

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SUMMARYPapillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. On the contrary, primary thyroid lymphoma (PTL) is a rare disease, accounting for 2% to 5% of all thyroid malignancies. Despite several cases in which both PTC and PTL arise in the setting of Hashimoto's thyroiditis (HT), the coexistence of both tumors in HT patients is very rare. Herein we report the case of a 66-year-old woman with long-standing nodular HT under replacement therapy, who presented with a fast, painless enlargement in the right anterior side of the neck. Thyroid ultrasonography demonstrated increased growth of a hypoechoic nodule in the right lobe measuring 32 x 20 mm. A total thyroidectomy was performed, and histology revealed a diffuse large B-cell lymphoma (DLBCL) on a background of florid HT. Moreover, a unifocal papillary microcarcinoma, classical variant (7 mm, pT1aNxMx), was discovered. The patient was then treated with chemotherapy for the PTL, but she did not undergo radioactive iodine ablation treatment for the microPTC as per guidelines. Two years after surgery, the patient had no evidence of recurrence of either malignancy. This rare case highlights the importance of monitoring HT patients with nodular lesions, especially if they have long-standing disease. In addition, PTL should be considered for differential diagnosis in elder HT patients who present with sudden thyroid enlargement. Arch Endocrinol Metab. 2017;61(6):643-6

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Section: Introductionmentioning

confidence: 99%

Coexistence of diffuse large B-cell lymphoma and papillary thyroid carcinoma in a patient affected by Hashimoto's thyroiditis

Trovato

Giuffrida

Seminara³

et al. 2017

Arch. Endocrinol. Metab.

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“…[1345] Simultaneous occurrence of both papillary carcinoma and PTL in HT is very rare. [346] Here, we report such association in a 32-year-old female, who presented with solitary thyroid nodule. Complete evaluation revealing HT with stage IE non-hodgkin lymphoma (NHL) and papillary carcinoma, who was treated with R-CHOP regime.…”

Section: Introductionmentioning

confidence: 83%

Hashimotos thyroiditis with coexistent papillary carcinoma and non-hodgkin lymphoma-thyroid

Jayaprakash¹,

KishanPrasad²,

Hegde³

et al. 2014

Ann Med Health Sci Res

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Lymphocytic thyroiditis and hashimoto's thyroiditis (HT) are the two main forms of autoimmune thyroiditis among which the latter is most frequent. A vast majority of cases of papillary carcinoma and primary thyroid lymphoma (PTL) arise in the setting of HT. A case of 32-year-old female who presented with thyroid enlargement, post-thyroidectomy showed hashimoto's thyroiditis (HT) with coexistent papillary carcinoma and non-hodgkin lymphoma (NHL). The immunohistochemistry was positive for CD 20, CD 45, bcl 2 for lymphoma, low and high molecular cytokeratin for papillary carcinoma. The staging studies showed no evidence of metastasis. It is thus concluded that papillary carcinoma and NHL can coexist with HT. The thyroid lymphoma or papillary carcinoma has to be thought off, whenever patients presents with sudden enlargement in a known case of HT. A patient presenting with concomitant primary thyroid lymphoma and papillary thyroid carcinoma must be judiciously evaluated, since, the treatment has to prioritize the tumor with worst stage at the time of diagnosis.

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“…In addition to the histopathological analysis of the thyroid tissue, an immunohistochemical staining with monoclonal antibodies should also be performed. [4] When the lymphoma is diagnosed, it should be differentiated from the systemic lymphoma that progresses with the secondary involvement of the thyroid gland. There are conflicting views about the surgical treatment of lymphomas of the thyroid.…”

Section: Discussionmentioning

confidence: 99%

A rare coexistence of thyroid lymphoma with papillary thyroid carcinoma

et al. 2013

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Diseases of the thyroid gland are frequently seen in general practice. Lymphoma of the thyroid is one of the rarest tumors. Its coexistence with papillary thyroid carcinoma is even rarer. Here, we present a 50-year-old female patient, who presented to our clinic with complaints of a rapidly growing lump on her neck, aphagia, and shortness of breath. A total thyroidectomy was performed. Histopathological analysis revealed the concomitant existence of papillary tumor. It should be noted that tumors with different histopathological behavior may rarely coexist with lymphoma in the thyroid gland. Masses growing rapidly in the thyroid shall suggest lymphoma.

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Concomitant thyroid Malt lymphoma and papillary thyroid carcinoma

Cited by 27 publications

References 17 publications

Coexistence of diffuse large B-cell lymphoma and papillary thyroid carcinoma in a patient affected by Hashimoto's thyroiditis

Coexistence of diffuse large B-cell lymphoma and papillary thyroid carcinoma in a patient affected by Hashimoto's thyroiditis

Hashimotos thyroiditis with coexistent papillary carcinoma and non-hodgkin lymphoma-thyroid

A rare coexistence of thyroid lymphoma with papillary thyroid carcinoma

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