Concomitant presentation of acute myeloid leukemia with T-cell large granular lymphocytic leukemia

Malani, Ashok K.; Gupta, Chakshu; Rangineni, Rajgopal; Singh, Jaswinder; Ammar, Hussam

doi:10.1080/02841860600827139

Cited by 6 publications

(2 citation statements)

References 15 publications

(10 reference statements)

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“…LGL clones have been also described in myeloproliferative neoplasms (MPN) and AML, even though this association is rarer (Table 2). There are case reports describing the association of LGL clones with AML, acute promyelocytic leukemia (APL), essential thrombocythemia, chronic myeloid leukemia (CML), and chronic myelomonocytic leukemia (38)(39)(40)(41)(42)(43)(44). Again, a hallmark of this association is cytopenia.…”

Section: Lgl Expansion In Other Myeloid Neoplasmsmentioning

confidence: 99%

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Large Granular Lymphocyte Expansion in Myeloid Diseases and Bone Marrow Failure Syndromes: Whoever Seeks Finds

et al. 2021

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Large granular lymphocytes (LGL) are lymphoid cells characterized by either a T-cell or a natural killer phenotype whose expansion may be reactive to toxic, infectious, and neoplastic conditions, or result from clonal selection. Recently, the higher attention to LGL clones led to their detection in many clinical conditions including myeloid neoplasms and bone marrow failures. In these contexts, it is still unclear whether LGL cells actively contribute to anti-stem cell autoimmunity or are only a reaction to dysplastic/leukemic myelopoiesis. Moreover, some evidence exists about a common clonal origin of LGL and myeloid clones, including the detection of STAT3 mutations, typical of LGL, in myeloid precursors from myelodysplastic patients. In this article we reviewed available literature regarding the association of LGL clones with myeloid neoplasms (myelodysplastic syndromes, myeloproliferative neoplasms, and acute myeloid leukemias) and bone marrow failures (aplastic anemia and pure red cell aplasia, PRCA) focusing on evidence of pathogenic, clinical, and prognostic relevance. It emerged that LGL clones may be found in up to one third of patients, particularly those with PRCA, and are associated with a more cytopenic phenotype and good response to immunosuppression. Pathogenically, LGL clones seem to expand after myeloid therapies, whilst immunosuppression leading to LGL depletion may favor leukemic escape and thus requires caution.

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Section: Lgl Expansion In Other Myeloid Neoplasmsmentioning

confidence: 99%

“…, and the patient died(39). Finally, Malani et al reported a case of concomitant presentation of T-LGLL with AML in an elderly patient who was treated with combination chemotherapy with good outcome(40). Overall, these experiences suggest a relationship among LGL and AML clones: chemotherapyinduced leukemia depletion leads to LGL expansion, whilst…”

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confidence: 99%

Large Granular Lymphocyte Expansion in Myeloid Diseases and Bone Marrow Failure Syndromes: Whoever Seeks Finds

et al. 2021

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T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities

Wei

Papavassiliou

Rehder

et al. 2014

Pathology - Research and Practice

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Chronic Lymphocytic Leukemia Associated with Myelodysplastic Syndrome with Ring Sideroblasts

Charafeddine

Ibrahim²,

Mahfouz³

et al. 2010

Southern Medical Journal

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Diagnosis of myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) and chronic lymphocytic leukemia (CLL) in the same patient is extremely rare. We describe a 69-year-old CLL patient who developed MDS with ring sideroblasts 1 year after diagnosis of CLL and without any previous treatment. Diagnosis was based on flow cytometry, bone marrow aspirate morphology, and iron stain. Our findings indicate that the 2 disorders belong to 2 different hematopoietic clones in this patient. In cases of worsening anemia in CLL patients, it is recommended that an iron stain be performed on bone marrow aspirates to exclude a coexistent malignancy such as refractory anemia with ring sideroblasts.

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Concomitant presentation of acute myeloid leukemia with T-cell large granular lymphocytic leukemia

Cited by 6 publications

References 15 publications

Large Granular Lymphocyte Expansion in Myeloid Diseases and Bone Marrow Failure Syndromes: Whoever Seeks Finds

Large Granular Lymphocyte Expansion in Myeloid Diseases and Bone Marrow Failure Syndromes: Whoever Seeks Finds

T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: Metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities

Chronic Lymphocytic Leukemia Associated with Myelodysplastic Syndrome with Ring Sideroblasts

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