Concomitant overdosing of other drugs in patients with paracetamol poisoning

Schmidt, Lars E.; Dalhoff, Kim

doi:10.1046/j.0306-5251.2001.01508.x-i1

Cited by 6 publications

(11 citation statements)

References 32 publications

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“…During the 8 d of active treatment with fluoxetine, mean norfluoxetine concentrations rose from 25 to 80 ng/mL. During the 14 to 31 d after sessation oftreatment they went from 55 to 45 ng/mL (226). Further discussion on the effect of long half-life of SSRI metabolites can be found in the relevant chapter in this monograph.…”

Section: Lnteractions With Serotonin Selective Reuptake Lnhibitorsmentioning

confidence: 96%

“…Pharmacokinetically significant drug interactions have, however, been identified (Table 23). Fluoxetine was found to inhibit the elimination of alprazolam (225,226) and diazepam (227), but was reported as without effect on clonazepam (226) and triazolam (228).…”

Section: Lnteractions With Serotonin Selective Reuptake Lnhibitorsmentioning

confidence: 97%

“…For subjects that took placebo first, the inhibition of alprazolam elimination was significant; for those that took fluoxetine first, it was not. The reason for this was that in subjects that took fluoxetine first, norfluoxetine plasma concentrations were stiH quite high (226). During the 8 d of active treatment with fluoxetine, mean norfluoxetine concentrations rose from 25 to 80 ng/mL.…”

Section: Lnteractions With Serotonin Selective Reuptake Lnhibitorsmentioning

confidence: 99%

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Handbook of Drug Interactions

Mozayani¹,

Raymon²

2004

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Section: Lnteractions With Serotonin Selective Reuptake Lnhibitorsmentioning

confidence: 96%

Section: Lnteractions With Serotonin Selective Reuptake Lnhibitorsmentioning

confidence: 97%

Section: Lnteractions With Serotonin Selective Reuptake Lnhibitorsmentioning

confidence: 99%

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Handbook of Drug Interactions

Mozayani¹,

Raymon²

2004

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“…In studies on the pharmacodynamic responses no effect was found for midazolam [274,278] or temazepam [281]. Interestingly, Kroboth et al [281] found minimal stimulation to the benzodiazepine effect in woman taking oral contraceptives along with alprazolam, triazolam, and lorazepam. The finding for lorazepam was contrary to the pharmacokinetic response.…”

Section: Interactions With Oral Contraceptivesmentioning

confidence: 99%

“…Metabolism of acetaminophen occurs primarily by phase II conjugation of the aromatic hydroxyl group with glucuronic acid (~60%) and sulfuric acid (~30%) and a much smaller fraction (~5%) is oxidized by CYP2E1 into the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI) [280]. Normally, the NAPQI metabolite is either reduced back to acetaminophen or inactivated by conjugation with glutathione, a scavenger of free radicals, and then excreted in urine after further phase II metabolism to produce cysteine and mercapturic acid [281]. A schematic diagram of the metabolism of acetaminophen in the body is shown in Fig.…”

Section: Drug Interactions Involving Cyp2e1mentioning

confidence: 99%

Handbook of Drug Interactions

Karalliedde¹,

Henry²

2012

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PrefaceAdverse drug reactions and drug interactions remain a major issue in 2011. During the second edition of our book, FDA reported greater than 370,000 serious adverse events in 2009 and more than 100,000 for the first quarter of 2010. The Adverse Event Reporting System is a database that gives computerized statistics used to support FDA's post-marketing safety surveillance for all approved drugs. A serious event is defined as requiring hospitalization, being life-threatening, causing disability or congenital anomalies, for example. Importantly, more than 63,000 deaths were recorded in 2009, and more than 20,000 occured during the first quarter of 2010.The second edition of Handbook of Drug Interactions: A Clinical and Forensic Guide has been updated to reflect new information and also includes new chapters of interest. In this respect, it is a continuation of the first edition and part of the ongoing story of drug-drug interactions.Pharmacogenomics is a rapidly growing field covering the genetic basis for individual variability in drug responses. This new section allows the reader to review important polymorphisms in drug metabolizing enzymes and applies the findings to forensic interpretation through interesting cases involving opiates.Although the section relating to central nervous system drugs encompasses a number of potential drugs with illicit use such as benzodiazepines and opiates, a chapter dealing exclusively with drugs of abuse has been added to the second edition. Cocaine, amphetamines, cannabis, flunitrazepam and GHB are now discussed. Alcohol and nicotine are still covered in the section related to environmental and social pharmacology.The existing chapters from the first edition have, in most cases, been updated and edited to reflect new data or bring out better tables and diagrams. More recent drugs and formulations are included. Recent references have been added for completeness. This volume emphasizes explanations when possible and covers both pharmacokinetic and pharmacodynamic drug interactions. The result, we hope, will continue to prove useful to health and forensic professionals as well as students.

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The impact of current tobacco use on the outcome of paracetamol poisoning

Schmidt

Dalhoff

2003

Aliment Pharmacol Ther

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SUMMARYBackground: Tobacco smoke contains a number of substances that are capable of inducing cytochrome P450. Consequently, current tobacco use may enhance the hepatotoxicity from a paracetamol overdose by increasing the oxidative metabolism of paracetamol. Aim: To evaluate, by multivariate analysis, the effect of current tobacco use on the morbidity and mortality from paracetamol-induced hepatotoxicity. Methods: A retrospective study was carried out on the basis of the hospital charts of 602 patients admitted with single-dose paracetamol poisoning for whom information on current tobacco use was available. Results: In patients admitted with paracetamol poisoning, the rate of current daily tobacco use of 70% (424

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Concomitant overdosing of other drugs in patients with paracetamol poisoning

Cited by 6 publications

References 32 publications

Handbook of Drug Interactions

Handbook of Drug Interactions

Handbook of Drug Interactions

The impact of current tobacco use on the outcome of paracetamol poisoning

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