Handbook of Drug Interactions

Abstract

PrefaceAdverse drug reactions and drug interactions remain a major issue in 2011. During the second edition of our book, FDA reported greater than 370,000 serious adverse events in 2009 and more than 100,000 for the first quarter of 2010. The Adverse Event Reporting System is a database that gives computerized statistics used to support FDA's post-marketing safety surveillance for all approved drugs. A serious event is defined as requiring hospitalization, being life-threatening, causing disability or congenital anomalies, for example. Importantly, more than 63,000 deaths were recorded in 2009, and more than 20,000 occured during the first quarter of 2010.The second edition of Handbook of Drug Interactions: A Clinical and Forensic Guide has been updated to reflect new information and also includes new chapters of interest. In this respect, it is a continuation of the first edition and part of the ongoing story of drug-drug interactions.Pharmacogenomics is a rapidly growing field covering the genetic basis for individual variability in drug responses. This new section allows the reader to review important polymorphisms in drug metabolizing enzymes and applies the findings to forensic interpretation through interesting cases involving opiates.Although the section relating to central nervous system drugs encompasses a number of potential drugs with illicit use such as benzodiazepines and opiates, a chapter dealing exclusively with drugs of abuse has been added to the second edition. Cocaine, amphetamines, cannabis, flunitrazepam and GHB are now discussed. Alcohol and nicotine are still covered in the section related to environmental and social pharmacology.The existing chapters from the first edition have, in most cases, been updated and edited to reflect new data or bring out better tables and diagrams. More recent drugs and formulations are included. Recent references have been added for completeness. This volume emphasizes explanations when possible and covers both pharmacokinetic and pharmacodynamic drug interactions. The result, we hope, will continue to prove useful to health and forensic professionals as well as students.

Modelling and investigation of amoxicillin chemical interaction with mineral waters containing a significant amount of calcium and magnesium salts

“…In that very same study, the influence of water intake was determining (Welling et al 1977). It also happens frequently that patients are simultaneously taking several drugs (Mozayani and Raymon 2012;Yeh et al 2009). In this case, the possibility of drug interactions should be considered.…”

Figure 5 from: Dobrova AO, Golovchenko OS, Georgiyants VA (2021) Modelling and investigation of amoxicillin chemical interaction with mineral waters containing a significant amount of calcium and magnesium salts. Pharmacia 68(1): 101-107. https://doi.org/10.3897/pharmacia.68.e39573

“…In that very same study, the influence of water intake was determining (Welling et al 1977). It also happens frequently that patients are simultaneously taking several drugs (Mozayani and Raymon 2012;Yeh et al 2009). In this case, the possibility of drug interactions should be considered.…”