Concomitant expression of ezrin and HER2 predicts distant metastasis and poor prognosis of patients with salivary gland carcinomas

Hashimoto, Kazuki; Hayashi, Ryuichi; Mukaigawa, Takashi; Yamazaki, Manabu; Fujii, Satoshi

doi:10.1016/j.humpath.2017.02.017

Cited by 10 publications

(10 citation statements)

References 22 publications

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“…The results suggested that ezrin expression is significantly increased in cancers of mesenchymal origin (sarcomas). The prognostic value of ezrin has been proposed for numerous types of cancers . However, the clinical prognostic significance of ezrin in patients with bone and soft tissue sarcomas remains inconclusive.…”

Section: Discussionmentioning

confidence: 99%

“…In cancer progression, ezrin is involved in cell adhesion, migration, and invasion as well as tumor growth and metastasis by acting as a key molecule involved in membrane organization or cellular signal transduction [9][10][11][12]. Due to the potential importance of ezrin in cancer, the prognostic significance of ezrin has been evaluated in numerous types of cancers [13][14][15][16]. However, the results have been somewhat contradictory [15,17,18].…”

mentioning

confidence: 99%

“…Due to the potential importance of ezrin in cancer, the prognostic significance of ezrin has been evaluated in numerous types of cancers [13][14][15][16]. However, the results have been somewhat contradictory [15,17,18]. Recent meta-analyses have revealed that elevated ezrin expression is associated with poor prognosis in patients with a variety of solid tumors [19,20].…”

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confidence: 99%

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The clinical prognostic significance of ezrin in patients with bone and soft tissue sarcomas: a meta‐analysis

Wang

et al. 2019

FEBS Open Bio

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Ezrin is a member of the ezrin–radixin–moesin (ERM) protein family and has been shown to be associated with poor prognosis in patients with a variety of solid tumors. However, the clinical prognostic significance of ezrin in patients with bone and soft tissue sarcomas remains unclear. Here, we performed a systematic meta‐analysis by searching PubMed, the Cochrane Library Database, EMBASE, the Web of Science, and the CBM, WanFang Med Online and CNKI databases. In total, 19 studies with a total of 1316 bone and soft tissue sarcoma patients were included. Pooled analyses showed that ezrin overexpression was correlated with a higher rate of tumor metastasis (OR 6.59, 95% CI: 2.84–15.33, P < 0.01, PFDR < 0.01) and recurrence (OR 3.18, 95% CI: 1.88–5.37, P < 0.01, PFDR < 0.01) and a more advanced tumor grade (OR 3.252, 95% CI: 1.371–7.715, P = 0.01, PFDR = 0.03). Moreover, elevated ezrin expression could predict poor OS (HR 3.02, 95% CI: 2.35–3.89, P < 0.01, PFDR < 0.01), MFS (HR 5.22, 95% CI: 2.08–13.08, P < 0.01, PFDR < 0.01), and EFS (HR 1.07, 95% CI: 1.03–1.11, P < 0.01, PFDR < 0.01). Subgroup analyses revealed the underlying sources of heterogeneity. Publication bias was observed in the analysis of metastasis. Sensitivity analysis revealed that the results were robust. Our findings indicated that ezrin overexpression was significantly correlated with poor survival and more advanced tumor progression in bone and soft tissue sarcomas, which suggests that ezrin might be a valuable prognostic biomarker and a potential therapeutic target.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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The clinical prognostic significance of ezrin in patients with bone and soft tissue sarcomas: a meta‐analysis

Wang

et al. 2019

FEBS Open Bio

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“…Moreover, Ezrin is responsible for cellular polarization in pancreatic cancer associated macrophages (Chang et al, 2020). Enriched Ezrin expression has been detected in salivary gland carcinomas, which was significantly correlated with the levels of other cancerous molecular markers such as Ki67, HER2, p53, male sex, high-grade histopathology, and distant tumor metastasis (Hashimoto et al, 2017). Additionally, in lung cancer cells, activated Ezrin facilitates mechanical transduction from the cytoskeleton to the membrane and regulates the malignant process in a tension-dependent manner (Zhang et al, 2019).…”

Section: Cancer-promoting Rolesmentioning

confidence: 95%

Ezrin Mediates Invasion and Metastasis in Tumorigenesis: A Review

Song

Zhang

et al. 2020

Front. Cell Dev. Biol.

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“…Ezrin is an important member of ERM (ezrin, radixin, and moesin) proteins, which is critical for structural stability and integrity maintenance (14). Recent studies show that Ezrin can act as a tumor metastasis regulator in invasion and metastasis of many types of cancer (15)(16)(17)(18). Besides, it also mediates many cellular activities such as polarity, motility, adhesion, and survival which are associated with cancer development and progression (19,20).…”

Section: Introductionmentioning

confidence: 99%

Expression Patterns of Ezrin and AJAP1 and Clinical Significance in Breast Cancer

Wang

et al. 2022

Front. Oncol.

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Ezrin and adherens junction-associated protein 1 (AJAP1) are structural proteins which are involved in numerous human malignancies. However, little is known about the relationship between them in breast cancer. This study was set out to investigate the relationship between them and to further explore the mechanism of AJAP1-mediating cytoskeleton in breast cancer progression. Ezrin and AJAP1 expressions were detected in 377 samples of breast cancer by immunohistochemistry, and different expression patterns between AJAP1 and Ezrin with clinicopathological parameters were analyzed. Besides, univariate and multivariate Cox models were used to evaluate their prognostic potential. Enzyme-linked immunosorbent assay, Western blot, qRT-PCR, and phalloidin staining of F-actin were used to explore the relationship and the mechanism between AJAP1 and Ezrin in cytoskeleton arrangement. 377 cases of breast cancer results showed that AJAP1 expression was negatively related with histological grade and lymph node involvement and could be an independent prognosis marker of breast cancer. AJAP1 expression tended to be higher in the Ezrin-negative expression case. Patients with AJAP1negative and Ezrinpositive expression had a worse prognosis (p < 0.0001) and shorter DFS (p = 0.015). More importantly, AJAP1 depletion increased the cell ability of F-actin formation through promoting Ezrin expression. AJAP1 depletion might mediate breast cancer malignancy potential through promoting Ezrin expression and cytoskeleton formation.

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Concomitant expression of ezrin and HER2 predicts distant metastasis and poor prognosis of patients with salivary gland carcinomas

Cited by 10 publications

References 22 publications

The clinical prognostic significance of ezrin in patients with bone and soft tissue sarcomas: a meta‐analysis

The clinical prognostic significance of ezrin in patients with bone and soft tissue sarcomas: a meta‐analysis

Ezrin Mediates Invasion and Metastasis in Tumorigenesis: A Review

Expression Patterns of Ezrin and AJAP1 and Clinical Significance in Breast Cancer

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