Ezrin Mediates Invasion and Metastasis in Tumorigenesis: A Review

Song, Yanan; Ma, Xiaokun; Zhang, Miao; Wang, Menghan; Wang, Guoyu; Ye, Ying; Xia, Weiya

doi:10.3389/fcell.2020.588801

Cited by 55 publications

(48 citation statements)

References 118 publications

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“…Moreover, Ki67, ezrin, and vimentin may serve as potential therapeutic targets in cancer. Thus, it is expected that identification of specific antisense nucleotides or small molecules to inhibit the activity of these proteins would lead to the discovery of antiproliferative and antimetastatic drugs [67,99,100]. This PDX collection provides a valuable platform for biomarker discovery and drug testing for preclinical studies.…”

Section: Discussionmentioning

confidence: 99%

“…Vimentin is a canonical mesenchymal marker and may indicate differentiation and/or EMT status [63]; it is associated with cell migration and increased metastatic potential [64,65]. Ezrin is an actin-related protein that connects the cytoskeleton to the plasma membrane and is linked with local invasions [66] and metastasis [67]. Ki67 is a nuclear protein involved in cell proliferation regulation that has also been associated with tumor aggressiveness and poor prognosis [68][69][70].…”

Section: Vimentin and Ezrin Protein Expression Changes During Pdx Passagesmentioning

confidence: 99%

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Increased Tumor Growth Rate and Mesenchymal Properties of NSCLC-Patient-Derived Xenograft Models during Serial Transplantation

Pardo-Sánchez

Mancheño

Cerón

et al. 2021

Cancers

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Non-small-cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. The high mortality is very often a consequence of its late diagnosis when the cancer is already locally advanced or has disseminated. Advances in the study of NSCLC tumors have been achieved by using in vivo models, such as patient-derived xenografts. Apart from drug screening, this approach may also be useful for study of the biology of the tumors. In the present study, surgically resected primary lung cancer samples (n = 33) were implanted in immunodeficient mice, and nine were engrafted successfully, including seven adenocarcinomas, one squamous-cell carcinoma, and one large-cell carcinoma. ADC tumors bearing the KRAS-G12C mutation were the most frequently engrafted in our PDX collection. Protein expression of vimentin, ezrin, and Ki67 were evaluated in NSCLC primary tumors and during serial transplantation by immunohistochemistry, using H-score. Our data indicated a more suitable environment for solid adenocarcinoma, compared to other lung tumor subtypes, to grow and preserve its architecture in mice, and a correlation between higher vimentin and ezrin expression in solid adenocarcinomas. A correlation between high vimentin expression and lung adenocarcinoma tumors bearing KRAS-G12C mutation was also observed. In addition, tumor evolution towards more proliferative and mesenchymal phenotypes was already observed in early PDX tumor passages. These PDX models provide a valuable platform for biomarker discovery and drug screening against tumor growth and EMT for lung cancer translational research.

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Section: Discussionmentioning

confidence: 99%

Section: Vimentin and Ezrin Protein Expression Changes During Pdx Passagesmentioning

confidence: 99%

Increased Tumor Growth Rate and Mesenchymal Properties of NSCLC-Patient-Derived Xenograft Models during Serial Transplantation

Pardo-Sánchez

Mancheño

Cerón

et al. 2021

Cancers

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“…These results strongly suggest that the loss of WWOX drives metastasis in TNBC by JAK2/STAT3 axis [15] (Figure 2). Ezrin is an actin-binding protein belonging to the ERM (Ezrin/Radixin/Moesin) family of proteins that regulate cell polarity, adhesion, and invasion through the control of various signaling pathways [94]. Ezrin has been shown to promote cell migration and invasion in several types of cancer where high protein expression has been correlated with poor patient prognosis.…”

Section: Wwox Interacts and Affects The Function Of Components Of Oncogenic Pathwaysmentioning

confidence: 99%

Molecular Functions of WWOX Potentially Involved in Cancer Development

Taouis

Driouch

Lidereau

et al. 2021

Cells

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The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of WWOX in a chromosomal region frequently altered in human cancers has initiated multiple current studies to establish its role in this disease. All of this work suggests that WWOX, due to its ability to interact with a large number of partners, exerts its tumor suppressive activity through a wide variety of molecular actions that are mostly cell specific.

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“…For example, similar to other cells types such as neutrophils and melanoma cells, the cell rear is enriched in Ezrin, a member of the ERM protein family (Lorentzen et al, 2011;Hind et al, 2016;Song et al, 2020), as well as Extended synaptotagminlike protein 2a (Esyt2a) (Giordano et al, 2013) and Septins (Woods and Gladfelter, 2021). In its active form, Ezrin links the plasma membrane to the underlying actin cortex (Song et al, 2020), while Esyt2a connects the endoplasmic reticulum (ER) to the plasma membrane (Zaman et al, 2020), thereby locally inhibiting the inflation of blebs. The Septins localized to the cell rear form structures that increase cortex rigidity and serve as scaffolds for other proteins (Woods and Gladfelter, 2021).…”

Section: Polarized Distribution Of Molecules and Organelles In Migrating Pgcsmentioning

confidence: 99%

Zebrafish Primordial Germ Cell Migration

Aalto

Olguín-Olguín

Raz

2021

Front. Cell Dev. Biol.

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Similar to many other organisms, zebrafish primordial germ cells (PGCs) are specified at a location distinct from that of gonadal somatic cells. Guided by chemotactic cues, PGCs migrate through embryonic tissues toward the region where the gonad develops. In this process, PGCs employ a bleb-driven amoeboid migration mode, characterized by low adhesion and high actomyosin contractility, a strategy used by other migrating cells, such as leukocytes and certain types of cancer cells. The mechanisms underlying the motility and the directed migration of PGCs should be robust to ensure arrival at the target, thereby contributing to the fertility of the organism. These features make PGCs an excellent model for studying guided single-cell migration in vivo. In this review, we present recent findings regarding the establishment and maintenance of cell polarity that are essential for motility and discuss the mechanisms by which cell polarization and directed migration are controlled by chemical and physical cues.

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Ezrin Mediates Invasion and Metastasis in Tumorigenesis: A Review

Cited by 55 publications

References 118 publications

Increased Tumor Growth Rate and Mesenchymal Properties of NSCLC-Patient-Derived Xenograft Models during Serial Transplantation

Increased Tumor Growth Rate and Mesenchymal Properties of NSCLC-Patient-Derived Xenograft Models during Serial Transplantation

Molecular Functions of WWOX Potentially Involved in Cancer Development

Zebrafish Primordial Germ Cell Migration

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