Concomitant administration of vitamin E does not change the side effects of isotretinoin as used in acne vulgaris: A randomized trial

Strauss, John S.; Gottlieb, Alice B.; Jones, Terry M.; Koo, John; Leyden, James J.; Lucky, Anne W.; Pappas, Anastasios; Mclane, G. John; Leach, Eileen Enny

doi:10.1067/mjd.2000.110391

Cited by 29 publications

(21 citation statements)

References 15 publications

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“…However, a recent double-blinded, placebo-controlled study with 800 IU a day of vitamin E in patients on lower doses of isotretinoin (1 mg/kg) failed to demonstrate a significant difference in mucocutaneous side effects. 18 The risks of prescribing vitamin E are minimal, and toxicity is rare. There are a few patient populations in which vitamin E usage may cause concern.…”

Section: Mucocutaneous Side Effectsmentioning

confidence: 99%

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Preventing and Managing the Side Effects of Isotretinoin

Brelsford¹,

Beute²

2008

Seminars in Cutaneous Medicine and Surgery

123

111

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Section: Mucocutaneous Side Effectsmentioning

confidence: 99%

“…Vitamin E has been shown to improve the incidence of cholesterol and triglyceride elevation. 18 The use of dietary supplements may be a simple way of treating lipid side effects while allowing the patient to remain on an effective dose of isotretinoin.…”

Section: Lipid and Hepatic Effectsmentioning

confidence: 99%

Preventing and Managing the Side Effects of Isotretinoin

Brelsford¹,

Beute²

2008

Seminars in Cutaneous Medicine and Surgery

123

111

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“…Erythrocyte GSH levels, GSH-Px activity and LP levels of patients with acne vulgaris were higher in the treatment group than in the pre-treatment group, although plasma LP levels were lower in the treatment group than in the pre-treatment group. 36 The results of the studies evaluating the role of vitamin E on the side effect profile of retinoids are conflicting. In plasma, HDL-cholesterol is the major carrier of lipid peroxides.…”

Section: Discussionmentioning

confidence: 99%

Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study

Erturan

Nazıroğlu

Akkaya

2012

Cell Biochemistry & Function

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Acne vulgaris is the one of the most common skin diseases. Although isotretinoin (13-cis-retinoic acid) is an effective and well-tolerated medication, it has a wide range of side effects. Because the effects of isotretinoin on oxidant and antioxidant systems have not yet been clarified, we investigated plasma and erythrocyte antioxidant vitamins, lipid peroxidation (LP), reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) values in patients with acne vulgaris before and after isotretinoin treatment. The study was performed on the blood plasma and erythrocytes of 31 acne vulgaris patients. Blood samples were taken from the patients before treatment and after isotretinoin (oral and 0·5-0·7 mg·kg(-1)) treatment for 2 months. Plasma amtioxidant vitamins, erythrocyte malondialdehyde, GSH and GSH-Px levels were measured. Plasma vitamin E (p < 0·001), lipid peroxidation (LP) and serum high-density lipoprotein cholesterol (p < 0·001) values were significantly lower in the treatment group than in the pre-treatment group, although erythrocyte LP (p < 0·001), GSH (p < 0·01) and GSH-Px (p < 0·001), aspartate aminotransferase (p < 0·05), alanine aminotransferase (p < 0·05), density lipoprotein cholesterol (p < 0·001) and total cholesterol (p < 0·01) levels were significantly higher in the treatment group than in the pre-treatment group. Vitamins A, C and β-carotene concentrations did not change significantly between the two groups. In conclusion, the results of the current study indicate that isotretinoin treatment induces oxidative stress and liver damage by decreasing plasma vitamin E and increasing erythrocytes GSH-Px, GSH and liver enzyme values.

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“…2 Studies support supplementing vitamin E 800 international units (IU) daily for patients using topical retinoid treatment, but not for patients taking oral isotretinoin. 2,7,13 A double-blinded randomized study of 140 patients found no improvement of mucocutaneous adverse reactions, fatigue, or joint pain in patients using isotretinoin when they were given vitamin E 800 IU. 13 HYPERLIPIDEMIA Hyperlipidemia due to isotretinoin increases patients' risk for pancreatitis, stroke, and myocardial infarction; however, most studies have shown that lipid levels normalize when patients stop isotretinoin therapy.…”

Section: Review Articlementioning

confidence: 98%

“…2,7,13 A double-blinded randomized study of 140 patients found no improvement of mucocutaneous adverse reactions, fatigue, or joint pain in patients using isotretinoin when they were given vitamin E 800 IU. 13 HYPERLIPIDEMIA Hyperlipidemia due to isotretinoin increases patients' risk for pancreatitis, stroke, and myocardial infarction; however, most studies have shown that lipid levels normalize when patients stop isotretinoin therapy. A 2006 study examining the frequency of hypercholesterolemia associated with isotretinoin found that the drug activates receptors involved in lipoprotein metabolism, weakening the body's ability for lipolysis of triglyceride-rich lipoproteins.…”

Section: Review Articlementioning

confidence: 98%

Managing nonteratogenic adverse reactions to isotretinoin treatment for acne vulgaris

Reilly

Ritsema

2015

Journal of the American Academy of Physician Assistants

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Isotretinoin is the strongest, most effective oral treatment for patients with severe acne vulgaris, with remission rates of 89% and higher. Because of its potency, isotretinoin causes many adverse reactions. This article reviews common and severe adverse reactions to isotretinoin and how providers can best manage these reactions. Because of inconclusive research on the correlation between isotretinoin and depression and irritable bowel syndrome, providers should ask patients about symptoms monthly. Prescribing micronized isotretinoin and starting at the lowest dose with gradual upward titration also can help reduce the incidence of adverse reactions.

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Concomitant administration of vitamin E does not change the side effects of isotretinoin as used in acne vulgaris: A randomized trial

Cited by 29 publications

References 15 publications

Preventing and Managing the Side Effects of Isotretinoin

Preventing and Managing the Side Effects of Isotretinoin

Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study

Managing nonteratogenic adverse reactions to isotretinoin treatment for acne vulgaris

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