Concerning the Action of Curara and Physostigmine Upon Nerve Endings or Muscles

Edmunds, Charles W.; Roth, George B.

doi:10.1152/ajplegacy.1908.23.1.28

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“…(4) When curare, nicotine, coniine, sparteine or gelseminine are given mixed with physostigmine, either there is no action at all (curare) or both -actions appear separately though interfering with one another (nicotine, sparteine, gelseminine). (5) These results show, there exists a mutual antagonism between curare, nicotine, coniine, sparteine and gelseminine on one side and physostigmine on the other. (6) In the case of sparteine and probably in that of gelseminine the ineffectiveness of physostigmine was probably due to an inexcitable condition of the muscle caused by them.…”

Section: Summaprymentioning

confidence: 82%

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1916

The Journal of Physiology

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WHILST investigating the antagonistic action between certain drugs on the isolated intestine, I have noticed that the effect of physostigmine is either diminished or completely lost if administered subsequently to either nicotine or curare. Some other drugs such as coniine, sparteine, gelseminine are known to possess a somewhat similar effect to that of nicotine and curare in so far that they paralyse in various degrees both nerve cells and motor endings(l). Experiments were

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Section: Summaprymentioning

confidence: 82%