Conceptual combination of disinfection in regenerative endodontics: Conventional versus laser-assisted disinfection

Divya, D; Naik, SaraswathiV; Raju, O S; Bellal, Shivani; Basappa, N; Betur, ArchanaP

doi:10.4103/jcd.jcd_96_21

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…With respect to disinfection, maintaining a sterile working environment is crucial for all endodontic procedures, including regenerative therapy 31,32 . Nonetheless, regenerative treatments rely on living cells and natural physiological processes, so eliminating bacteria and ensuring the survival of endogenous cells can be complex undertakings, especially when using a bleeding technique.…”

Section: Discussionmentioning

confidence: 99%

Orthodontic Movement After Regenerative Endodontic Procedure in Mature Permanent Tooth Associated With Dens Invaginatus: A Case Report With 3-year Follow-Up

Martínez,

Oyonarte,

Concha

et al. 2024

Preprint

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Background Regenerative endodontic procedures (REPs) are innovative treatments aimed at restoring damaged dental structures. However, the effect of orthodontic movement on REP-treated teeth is not well understood and may have significant long-term consequences. This study aimed to evaluate the impact of orthodontic movement on a mature permanent tooth associated with dens invaginatus that has undergone a regenerative endodontic procedure (REP). Case presentation: This case involves a preliminary investigation into the effects of orthodontic movements on a mature REP-treated tooth. This could have the potential to enrich our collective understanding and guide treatment planning, leading to the development of clinical guidelines. This report describes the case of a 13-year-old male with a noncontributory medical history who presented with pulp necrosis and a chronic apical abscess (tooth number 2.2). Following REP according to the American Association of Endodontists' guidelines, the patient began orthodontic treatment after 9 months. Subsequent follow-ups at 9 months, 2 years, and 3 years post-REP revealed an asymptomatic state with minimal cervical discolouration and diminished cold sensitivity. Radiographic analyses revealed periapical healing, dentin wall thickening, and consistent root length. The treated tooth displayed a positive response to both REP and orthodontic treatment, yet further research is necessary to determine the long-term effects of orthodontic forces on REP-treated teeth. Conclusion Our findings suggest that orthodontic movement following REPs in mature permanent teeth is feasible and may also act as a protective factor against apical root resorption. Our experience indicates that a 9-month healing period permits successful orthodontic outcomes following REPs. Nonetheless, the predictability of outcomes and the ideal healing period before orthodontic movement is initiated remain to be established.

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Section: Discussionmentioning

confidence: 99%

Orthodontic Movement After Regenerative Endodontic Procedure in Mature Permanent Tooth Associated With Dens Invaginatus: A Case Report With 3-year Follow-Up

Martínez,

Oyonarte,

Concha

et al. 2024

Preprint

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“…CO 2 laser bursts effectively removed bacteria inoculated on pig skin in an experiment. A sterile environment is a prerequisite of regenerative endodontic treatment, which could be effectively achieved with the assistance of a CO 2 laser ( Mullarky et al, 1985 ; Nammour and Majerus, 1991 ; Divya et al, 2021 ). Low-level laser with 660 nm wavelength and 100 mW power has been used for sterilization of the decellularized lung tissues ( Lopes Guimarães et al, 2020 ).…”

Section: Sterilizationmentioning

confidence: 99%

“…Low-level laser with 660 nm wavelength and 100 mW power has been used for sterilization of the decellularized lung tissues ( Lopes Guimarães et al, 2020 ). Laser is an appropriate option for effectively disinfecting tissues, and its potential for disinfecting the dECM should be further explored ( Mullarky et al, 1985 ; Nammour and Majerus, 1991 ; Divya et al, 2021 ).…”

Section: Sterilizationmentioning

confidence: 99%

Decellularization in Tissue Engineering and Regenerative Medicine: Evaluation, Modification, and Application Methods

Neishabouri

Khaboushan

Daghigh

et al. 2022

Front. Bioeng. Biotechnol.

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Reproduction of different tissues using scaffolds and materials is a major element in regenerative medicine. The regeneration of whole organs with decellularized extracellular matrix (dECM) has remained a goal despite the use of these materials for different purposes. Recently, decellularization techniques have been widely used in producing scaffolds that are appropriate for regenerating damaged organs and may be able to overcome the shortage of donor organs. Decellularized ECM offers several advantages over synthetic compounds, including the preserved natural microenvironment features. Different decellularization methods have been developed, each of which is appropriate for removing cells from specific tissues under certain conditions. A variety of methods have been advanced for evaluating the decellularization process in terms of cell removal efficiency, tissue ultrastructure preservation, toxicity, biocompatibility, biodegradability, and mechanical resistance in order to enhance the efficacy of decellularization methods. Modification techniques improve the characteristics of decellularized scaffolds, making them available for the regeneration of damaged tissues. Moreover, modification of scaffolds makes them appropriate options for drug delivery, disease modeling, and improving stem cells growth and proliferation. However, considering different challenges in the way of decellularization methods and application of decellularized scaffolds, this field is constantly developing and progressively moving forward. This review has outlined recent decellularization and sterilization strategies, evaluation tests for efficient decellularization, materials processing, application, and challenges and future outlooks of decellularization in regenerative medicine and tissue engineering.

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“…Additionally, this irrigation created more cell-friendly dentin conditioning that was beneficial for SCAPs adhesion and survival. 97 Divya et al 98 showed that incorporating with AAE protocol, use of diode laser in the first appointment contributed to enhanced disinfection and significant outcome of periapical healing in necrotic immature teeth.…”

Section: Clinical Protocolmentioning

confidence: 99%

Expert consensus on regenerative endodontic procedures

Wei

Yang

Lin³

et al. 2022

Int J Oral Sci

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Regenerative endodontic procedures (REPs) is a biologic-based treatment modality for immature permanent teeth diagnosed with pulp necrosis. The ultimate objective of REPs is to regenerate the pulp-dentin complex, extend the tooth longevity and restore the normal function. Scientific evidence has demonstrated the efficacy of REPs in promotion of root development through case reports, case series, cohort studies, and randomized controlled studies. However, variations in clinical protocols for REPs exist due to the empirical nature of the original protocols and rapid advancements in the research field of regenerative endodontics. The heterogeneity in protocols may cause confusion among dental practitioners, thus guidelines and considerations of REPs should be explicated. This expert consensus mainly discusses the biological foundation, the available clinical protocols and current status of REPs in treating immature teeth with pulp necrosis, as well as the main complications of this treatment, aiming at refining the clinical management of REPs in accordance with the progress of basic researches and clinical studies, suggesting REPs may become a more consistently evidence-based option in dental treatment.

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Conceptual combination of disinfection in regenerative endodontics: Conventional versus laser-assisted disinfection

Cited by 5 publications

References 36 publications

Orthodontic Movement After Regenerative Endodontic Procedure in Mature Permanent Tooth Associated With Dens Invaginatus: A Case Report With 3-year Follow-Up

Orthodontic Movement After Regenerative Endodontic Procedure in Mature Permanent Tooth Associated With Dens Invaginatus: A Case Report With 3-year Follow-Up

Decellularization in Tissue Engineering and Regenerative Medicine: Evaluation, Modification, and Application Methods

Expert consensus on regenerative endodontic procedures

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