Conceptual combination in schizophrenia: Contrasting property and relational interpretations

Titone, Debra; Libben, Maya; Niman, Meg; Ranbom, Larissa J.; Levy, Deborah L.

doi:10.1016/j.jneuroling.2006.06.002

Cited by 19 publications

(16 citation statements)

References 61 publications

(66 reference statements)

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“…The AD results reported here are complementary to those reported by Titone et al (2007) in schizophrenia; in their study, patients with high amounts of thought disorder generated fewer relational but not property interpretations than control participants. The authors attribute this to deficits in controlled and flexible use of semantic knowledge in schizophrenia.…”

Section: Discussionsupporting

confidence: 64%

“…Panel A shows number of property interpretations, and Panel B shows number of relational interpretations generated, by participant group and stimulus type. To assess the relative generation of property and relational responses, we conducted separate analyses for each condition with the percentage of each response type as the dependent variable, following Titone et al (2007). This approach allowed us to determine whether a reduction in a given interpretation type results in an increase in another interpretation type, or in "other" or "I don't know" responses.…”

Section: Analysis 1: Property Vs Relational Interpretationsmentioning

confidence: 99%

“…These interpretations are referred to as "relational interpretations". On the basis of data from patients diagnosed with schizophrenia, Titone, Libben, Niman, Ranbom, and Levy (2007) suggest that successful generation of relational interpretations requires both activation of semantic information and post-retrieval selection mechanisms, and rests on the controlled and flexible integration of semantic knowledge.…”

Section: Introductionmentioning

confidence: 99%

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Generation of novel semantic representations in aging and Alzheimer’s disease

Taler¹,

Kousaie²,

Phillips³

et al. 2011

Journal of Neurolinguistics

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Section: Discussionsupporting

confidence: 64%

Section: Analysis 1: Property Vs Relational Interpretationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Generation of novel semantic representations in aging and Alzheimer’s disease

Taler¹,

Kousaie²,

Phillips³

et al. 2011

Journal of Neurolinguistics

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“…People with schizophrenia have difficulty noticing semantic violations in sentences [e.g., (Kuperberg, Kreher, Goff, McGuire, & David, 2006)], using context to resolve lexical ambiguity [e.g., (Salisbury, 2008; Sitnikova, Salisbury, Kuperberg, & Holcomb, 2002; Titone, Levy, & Holzman, 2000)], comprehending figurative language such as idioms and metaphors [e.g., (Titone, Holzman, & Levy, 2002; Titone, Libben, Niman, Ranbom, & Levy, 2007)], and quickly generating coherent inferences during discourse processing [e.g., (Ditman & Kuperberg, 2007)]. The causes of these “context processing” deficits remain unclear, however.…”

Section: Thought Disorder Language Disorder Speech Disorder and Comentioning

confidence: 99%

The genetic basis of thought disorder and language and communication disturbances in schizophrenia

Levy

Coleman

Sung

et al. 2010

Journal of Neurolinguistics

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Thought disorder as well as language and communication disturbances are associated with schizophrenia and are over-represented in clinically unaffected relatives of schizophrenics. All three kinds of dysfunction involve some element of deviant verbalizations, most notably, semantic anomalies. Of particular importance, thought disorder characterized primarily by deviant verbalizations has a higher recurrence in relatives of schizophrenic patients than schizophrenia itself. These findings suggest that deviant verbalizations may be more penetrant expressions of schizophrenia susceptibility genes than schizophrenia. This paper reviews the evidence documenting the presence of thought, language and communication disorders in schizophrenic patients and in their first-degree relatives. This familial aggregation potentially implicates genetic factors in the etiology of thought disorder, language anomalies, and communication disturbances in schizophrenia families. We also present two examples of ways in which thought, language and communication disorders can enrich genetic studies, including those involving schizophrenia. KeywordsSchizophrenia; Thought disorder; Language disorders; Communication disorders; Semantic anomalies; Genetics; Family studies; Linkage analyses; Endophenotypes Thought Disorder and SchizophreniaDue largely to the influence of Eugen Bleuler (Bleuler, 1911(Bleuler, /1950, thought disorder was considered virtually pathognomonic of the diagnosis of schizophrenia for many years. Kraepelin (Kraepelin, 1896(Kraepelin, /1919 is not credited with having had as much influence as Bleuler Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript in this respect, but he too was impressed with the centrality of disturbed thinking in dementia praecox. Kraepelin considered "derailments in the train of thought," which he named "akataphasia," to be a fundamental characteristic of the dementia of dementia praecox (Kraepelin, 1896(Kraepelin, /1919. Manifestations of derailment included loosening of associations ("the most different ideas follow one another with most bewildering want of connection..." p. 56) and incoherence ("bewilderingly nonsensical utterances ... apparently represent a senseless jiggling of words" p. 71). 1 Bleuler (Bleuler, 1911(Bleuler, /1950) considered "disorders of association" to be one of the four fundamental characteristics of the schizophrenias. He relegated the more conspicuous psychotic indicators, delusions and hallucinations, to secondary status as "acce...

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“…These scales/systems have provided important information about thought disorder, for example, that it is multifaceted and reflects a broad range of behaviors such as derailment, tangentiality, circumstantiality, illogicality, and incoherence. 1,6 Moreover, it has been suggested that thought disorder is heritable 36 ; a potential biomarker of psychiatric pathology 37 ; and is associated with aberrant semantic processing 38,39 ; neurocognitive liabilities 39 ; and abnormalities in prefrontal, 40 left-temporal, 41 and anterior cingulate 42 brain regions. 43 That being said, ratingbased approaches to measuring thought disorder are limited due to their reliance on ordinal scaling of clinician impression, which contributes to far from optimal inter-rater reliability (ie, reliability coefficients often below 0.70).…”

Section: How Can Rdoc Be Applied To the Study Of Thought Disorder?mentioning

confidence: 99%

Can RDoC Help Find Order in Thought Disorder?

Cohen

Fedechko

et al. 2017

Schizophrenia Bulletin

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Thought disorder is a pernicious and nonspecific aspect of numerous serious mental illnesses (SMIs) and related conditions. Despite decades of empirical research on thought disorder, our present understanding of it is poor, our clinical assessments focus on a limited set of extreme behaviors, and treatments are palliative at best. Applying a Research Domain Criteria (RDoC) framework to thought disorder research offers advantages to explicate its phenotype; isolate its mechanisms; and develop more effective assessments, treatments, and potential cures. In this commentary, we discuss ways in which thought disorder can be understood within the RDoC framework. We propose operationalizing thought disorder within the RDoC construct of language using psycholinguistic sciences, to help objectify and quantify language within individuals; technologically sophisticated paradigms, to allow naturalistic behavioral sampling techniques with unprecedented ecological validity; and computational modeling, to account for a network of interconnected and dynamic linguistic, cognitive, affective, and social functions. We also highlight challenges for understanding thought disorder within an RDoC framework. Thought disorder likely does not occur as an isomorphic dysfunction in a single RDoC construct, but rather, as multiple potential dysfunctions in a network of RDoC constructs. Moreover, thought disorder is dynamic over time and context within individuals. In sum, RDoC is a useful framework to integrate multidisciplinary research efforts aimed at operationalizing, understanding, and ameliorating thought disorder.

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Conceptual combination in schizophrenia: Contrasting property and relational interpretations

Cited by 19 publications

References 61 publications

Generation of novel semantic representations in aging and Alzheimer’s disease

Generation of novel semantic representations in aging and Alzheimer’s disease

The genetic basis of thought disorder and language and communication disturbances in schizophrenia

Can RDoC Help Find Order in Thought Disorder?

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