Concepts of immunostimulation to increase antiparasitic drug action

Kn, Masihi

doi:10.1007/s00436-002-0774-5

Cited by 6 publications

(3 citation statements)

References 55 publications

(42 reference statements)

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“…tem encompassing lymphocyte subsets, MACRO-PHAGES, dendritic and natural killer (NK) cells. Further mechanisms can involve induction or restoration of immune effector functions and tilting the balance towards CYTOKINE pathways germane to protection.A diverse array of recombinant, synthetic, and natural IMMUNOMODULATORY preparations for prophylaxis and treatment of various infections are available today [4][5][6]. A concise mind-map of the IMMUNOMODULATORS discussed in this chapter is summarised in Figure 1.…”

Section: C6mentioning

confidence: 99%

Anti-infective activity of immunomodulators

2005

Principles of Immunopharmacology

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Section: C6mentioning

confidence: 99%

Anti-infective activity of immunomodulators

2005

Principles of Immunopharmacology

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“…Immunostimulation aims to boost immune responses, potentially improving resistance to infections and diseases. 3,4 However, in certain instances, the improper use of immunomodulators (specifically immunostimulants) can paradoxically trigger pathological conditions, emphasizing the need for a nuanced and evidence-based approach to the use of immunomodulatory agents. 5 Vitamin D 3 has emerged as a versatile immunomodulator, exhibiting antibacterial and antiviral properties.…”

Section: Introductionmentioning

confidence: 99%

“…Immunomodulators can regulate the immune system by either stimulating or suppressing its components. Immunostimulation aims to boost immune responses, potentially improving resistance to infections and diseases. , However, in certain instances, the improper use of immunomodulators (specifically immunostimulants) can paradoxically trigger pathological conditions, emphasizing the need for a nuanced and evidence-based approach to the use of immunomodulatory agents …”

Section: Introductionmentioning

confidence: 99%

Evaluating the Impact of Vitamin D₃ on NF-κB and JAK/STAT Signaling Pathways in Drosophila melanogaster

Hardiyanti,

Djabir,

Fatiah

et al. 2024

ACS Omega

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This study delved into the consequences of prolonged administration of vitamin D 3 on innate immune systems, particularly NF-κB and JAK/STAT, in Drosophila melanogaster. The outcomes indicated that vitamin D 3 treatment exhibited a notable capacity to improve the survival of adult flies with compromised immune functions, a condition induced by the loss of PGRP-LB, particularly when the flies were exposed to heat-killed Escherichia coli. The PGRP-LB Δ mutant line that was treated with heat-killed E. coli experienced reduced survival. Treatment of heatkilled E. coli-treated PGRP-LB Δ with vitamin D 3 resulted in improved survival, and this phenotypic feature might be due to the downregulation of gene expression in the NF-κB and JAK/STAT pathways. However, a higher concentration of vitamin D 3 was associated with decreased survival, potentially linked to intricate immunological responses. The research also underscored the influence of vitamin D 3 on the expression of antioxidant genes, sod1 and sod2, indicating an augmented resistance to oxidative stress. Further, this study revealed the effect of vitamin D 3 on the reproductive status of the autoinflammatory model, showing an increase in pupae and adult flies with a treatment of 10 mM vitamin D 3 , suggesting the potential benefits of vitamin D 3 on the reproductive profile. Overall, this study provides preliminary insights into the complex interactions between vitamin D 3 , immune pathways, oxidative responses in the cell, and reproduction in Drosophila.

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Treatment with triterpenic fraction purified from Baccharis uncinella leaves inhibits Leishmania (Leishmania) amazonensis spreading and improves Th1 immune response in infected mice

et al. 2013

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The current medications used to treat leishmaniasis have many side effects for patients; in addition, some cases of the disease are refractory to treatment. Therefore, the search for new leishmanicidal compounds is indispensable. Recently, it was demonstrated that oleanolic- and ursolic-containing fraction from Baccharis uncinella leaves eliminated the promastigote and amastigote forms of Leishmania (Leishmania) amazonensis and L. (Viannia) braziliensis without causing toxic effects for J774 macrophages. Thus, the aim of the present work was to characterize the therapeutic effect of the triterpenic fraction in L. (L.) amazonensis-infected BALB/c mice. Oleanolic- and ursolic acid-containing fraction was extracted from B. uncinella leaves using organic solvents and chromatographic procedures. L. (L.) amazonensis-infected BALB/c mice were treated intraperitoneally with triterpenic fraction during five consecutive days with 1.0 and 5.0 mg/kg of triterpenic fraction, or with 10.0 mg/kg of amphotericin B drug. Groups of mice treated with the triterpenic fraction, presented with decreased lesion size and low parasitism of the skin-both of which were associated with high amounts of interleukin-12 and interferon gamma. The curative effect of this fraction was similar to amphotericin B-treated mice; however, the final dose, required to eliminate amastigotes, was lesser than amphotericin B. Moreover, triterpenic fraction did not cause microscopic alterations in liver, spleen, heart, lung, and kidney of experimental groups. This work suggests that this fraction possesses compounds that are characterized by leishmanicidal and immunomodulatory activities. From this perspective, the triterpenic fraction can be explored as a new therapeutic agent for use against American Tegumentar Leishmaniasis.

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Concepts of immunostimulation to increase antiparasitic drug action

Cited by 6 publications

References 55 publications

Anti-infective activity of immunomodulators

Anti-infective activity of immunomodulators

Evaluating the Impact of Vitamin D₃ on NF-κB and JAK/STAT Signaling Pathways in Drosophila melanogaster

Treatment with triterpenic fraction purified from Baccharis uncinella leaves inhibits Leishmania (Leishmania) amazonensis spreading and improves Th1 immune response in infected mice

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Concepts of immunostimulation to increase antiparasitic drug action

Cited by 6 publications

References 55 publications

Anti-infective activity of immunomodulators

Anti-infective activity of immunomodulators

Evaluating the Impact of Vitamin D3 on NF-κB and JAK/STAT Signaling Pathways in Drosophila melanogaster

Treatment with triterpenic fraction purified from Baccharis uncinella leaves inhibits Leishmania (Leishmania) amazonensis spreading and improves Th1 immune response in infected mice

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Product

Resources

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Evaluating the Impact of Vitamin D₃ on NF-κB and JAK/STAT Signaling Pathways in Drosophila melanogaster