Evaluating the Impact of Vitamin D3 on NF-κB and JAK/STAT Signaling Pathways in Drosophila melanogaster
Widya Hardiyanti,
Yulia Yusrini Djabir,
Dewita Fatiah
et al.
Abstract:This study delved into the consequences of prolonged administration of vitamin D 3 on innate immune systems, particularly NF-κB and JAK/STAT, in Drosophila melanogaster. The outcomes indicated that vitamin D 3 treatment exhibited a notable capacity to improve the survival of adult flies with compromised immune functions, a condition induced by the loss of PGRP-LB, particularly when the flies were exposed to heat-killed Escherichia coli. The PGRP-LB Δ mutant line that was treated with heat-killed E. coli experi… Show more
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