Concept, design and fabrication of smart orthopedic implants

Burny, Franz Léon; Donkerwolcke, M; Moulart, F; Bourgois, R; Puers, Robert; Schuylenbergh, Koenraad Van; Barbosa, Mário A.; Paiva, Olga C.; Rodes, Francis; Bégueret, Jean-Baptiste; Lawes, P

doi:10.1016/s1350-4533(00)00062-x

Cited by 96 publications

(72 citation statements)

References 6 publications

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“…Body movements impose dynamic loads that are convenient to be measured in implanted mechanical devices providing valuable information on the healing process and on the device varying environment [36,37]. Further, dynamic loads can be also taken to advantage in active tissue engineering strategies [6].…”

Section: Discussionmentioning

confidence: 99%

Osteoblast, fibroblast and in vivo biological response to poly(vinylidene fluoride) based composite materials

Costa

Ribeiro

Lopes

et al. 2012

J Mater Sci: Mater Med

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Electroactive materials can be taken to advantage for the development of sensors and actuators as well as for novel tissue engineering strategies. Composites based on poly(vinylidene fluoride), PVDF, have been evaluated with respect to their biological response. Cell viability and proliferation were performed in vitro both with Mesenchymal Stem Cells differentiated to osteoblasts and Human Fibroblast Foreskin 1. In vivo tests were also performed using 6-weekold C57Bl/6 mice. It was concluded that zeolite and clay composites are biocompatible materials promoting cell response and not showing in vivo pro-inflammatory effects which renders both of them attractive for biological applications and tissue engineering, opening interesting perspectives to development of scaffolds from these composites. Ferrite and silver nanoparticle composites decrease osteoblast cell viability and carbon nanotubes decrease fibroblast viability. Further, carbon nanotube composites result in a significant increase in local vascularization accompanied an increase of inflammatory markers after implantation.

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Section: Discussionmentioning

confidence: 99%

Osteoblast, fibroblast and in vivo biological response to poly(vinylidene fluoride) based composite materials

Costa

Ribeiro

Lopes

et al. 2012

J Mater Sci: Mater Med

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“…Furthermore, local antimicrobial therapies inefficiently penetrate established biofilms, thereby triggering changes in quorum sensing and gene expression that further contribute to antimicrobial resistance 16 . In the case of PMMA, the porous, nondegradable carrier matrix itself may also serve as a substrate for bacterial adhesion and subsequent biofilm formation 17,18 . We previously tethered antimicrobial compounds to titanium implant surfaces to address the need to prevent bacterial adhesion and biofilm formation.…”

mentioning

confidence: 99%

Vancomycin-Modified Implant Surface Inhibits Biofilm Formation and Supports Bone-Healing in an Infected Osteotomy Model in Sheep

Stewart

Barr

Engiles

et al. 2012

Journal of Bone and Joint Surgery

102

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“…Their experimental results show approximately 40 % link efficiency at 2.5-MHz operating frequency and an output power of 100 mW. In [23], a medical relevance of the monitoring of deformation of implants is presented. It is a powerful tool to evaluate nursing and rehabilitation exercises for tracing dangerous overloads while anticipating implant failure and observing the healing process.…”

Section: Inductive Link Designmentioning

confidence: 99%

Modeling induction and routing to monitor hospitalized patients in multi-hop mobility-aware body area sensor networks

Javaid

Ahmad

Tauqir

et al. 2016

J Wireless Com Network

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In wireless body area sensor networks (WBASNs), energy efficiency is an area of extreme significance. At first, we present a mathematical model for a non-invasive inductive link which is used to recharge the battery of an implanted biomedical device (pacemaker). Afterwards, we propose a distance-aware relaying energy-efficient (DARE) and mutual information-based DARE (MI-DARE) routing protocols for multihop mobility-aware body area sensor networks (MM-BASNs). Both the routing protocols and the non-invasive inductive link model are tested with the consideration of eight patients in a hospital unit under different topologies, where the vital signs of each patient are monitored through seven on-body sensors and an implanted pacemaker. To reduce energy consumption of the network, the sensors communicate with a sink via an on-body relay which is fixed on the chest of each patient. The behavior (static/mobile) and position of the sink are changed in each topology, and the impact of mobility due to postural changes of the patient(s) arms, legs, and head is also investigated. The MI-DARE protocol further prolongs the network lifetime by minimizing the number of transmissions. Simulation results show that the proposed techniques outperform contemporary schemes in terms of the selected performance metrics.

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Concept, design and fabrication of smart orthopedic implants

Cited by 96 publications

References 6 publications

Osteoblast, fibroblast and in vivo biological response to poly(vinylidene fluoride) based composite materials

Osteoblast, fibroblast and in vivo biological response to poly(vinylidene fluoride) based composite materials

Vancomycin-Modified Implant Surface Inhibits Biofilm Formation and Supports Bone-Healing in an Infected Osteotomy Model in Sheep

Modeling induction and routing to monitor hospitalized patients in multi-hop mobility-aware body area sensor networks

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