Concentrations sanguines d’antibiotiques chez les patients brûlés. Étude rétrospective sur cinq ans

Which Are the Best Regimens of Broad-Spectrum Beta-Lactam Antibiotics in Burn Patients? A Systematic Review of Evidence from Pharmacology Studies

“…They concluded that a regimen ranging from 3 to 16 g/day was needed (depending on CL R and age), preferably via CI, in order to achieve a target of 100% fT > MIC (duration of time that the free drug concentration remains above the MIC during a dosing interval) or greater against susceptible pathogens with an MIC up to a value of 8 mg/L. A study by Le Floch et al [38] confirmed that CI attained a fT > 4 × MIC target (duration of time that the drug concentration remains 4 times above the MIC during a dosing interval) in 77% of patients, although no details about MICs and dosing regimens were reported. Finally, Walstad et al [49] showed good tissue and burn blister fluid concentrations of ceftazidime after two doses of 1 g every 8 h via IIn.…”

“…They assumed a lenient PK/PD target of 40% fT > MIC and showed that mean daily doses of approximately 2 g for patients with normal renal function and 1 g for patients with renal failure (further regimen details were not provided) were able to achieve nearly 100% PTA for MICs ≤ 4 mg/L. Le Floch et al [38] reported their results using 120 concentration measurements of imipenem-cilastatin in burn patients, showing that Cmin was never higher than 6 mg/L when a mean total daily dose of 3 g was administered. However, the lack of some data made interpretation difficult.…”

Estimates of serious fungal infection burden in Côte d’Ivoire and country health profile

“…In Côte d'Ivoire, the Abidjan center for burn victims receives about 500 burn patients a year. So nearly 25 will develop candidemia [39]. We have assumed that 30% of candidaemia cases occur in intensive care.…”