Concentrations of Total Serum Immunoglobulin E, A, G and M in Stray Dogs with Healthy and Dermatological Problems

Abstract

SummaryIn this study, clinical and laboratory findings along with serum IgE, IgA, IgM and IgG concentrations were determined in stray dogs (healthy and with dermatological problems). It was determined that skin lesions were localized in the rate of 69.8% (n=44) and generalized in the rate of 30.2% (n=19) of sick animals. Serum IgE concentration in stray dogs with dermatologic problems was significantly higher (P<0.001) than that of healthy dogs whereas serum IgM and G concentrations were significantly lower (P<0.05). It was evaluated that, serum total immunoglobulin concentrations could be useful in making contribution to differential diagnosis of skin diseases in stray dogs. Keywords: Skin disease, Immunoglobulin E, A, G and M, Dog Sağlıklı ve Dermatolojik Problemli Başıboş Köpeklerde Total Serum İmmunoglobulin E, A, G ve M Konsantrasyonları ÖzetBu araştırmada sağlıklı ve deri problemleri bulunan başıboş köpeklerde serum IgE, IgA, IgM ve IgG konsantrasyonları ile birlikte klinik ve laboratuar bulgular belirlendi. Köpeklerde gözlenen tüm deri lezyonlarının %69.8 (n=44) oranında lokalize, %30.2 (n=19) oranında generalize lezyonlardan oluştuğu belirlendi. Deri problemleri bulunan köpeklerde sağlıklı gruba göre IgE konsantrasyonunun önemli düzeyde (P<0.001) yüksek, IgG ve IgM konsantrasyonlarının ise önemli düzeyde (P<0.05) düşük olduğu tespit edildi. Sonuç olarak, serum total immunoglobulin konsantrasyonlarının deri hastalıklarının ayırıcı tanısına katkı sağlayabileceği değerlendirildi.

Investigation of the relationship between atopic dermatitis of dogs and intestinal epithelial damage

“…In dogs, abundant IgE production occurs as a result of the organism's type 1 hypersensitivity response to environmental allergens such as house dust mites, mould mites, wheat dust, grass or vernal grass allergens, pollen, epidermal antigens, insect antigens and feathers, resulting in a significant increase in serum IgE levels (Fraser et al., 2003 ). Many researchers (Maden et al., 2013 ; Pucheu‐Haston et al., 2015 ) have reported high IgE production in house dust mite‐induced atopic dermatitis in dogs. Allergen‐specific IgE concentrations were found to be higher in environmental mite‐induced atopy (Pucheu‐Haston et al., 2015 ).…”

“…In atopic dermatitis, lesions occur on the face, concave surface of the auricle, lower abdomen, axilla, inguinal region, perineal region and distal extremities (Adam et al., 2022 ; Bizikova et al., 2015 ). Atopy is a type 1 hypersensitivity reaction of the body with immunoglobulin E (IgE) antibodies formed in the skin or in the blood circulation against environmental antigens (Maden et al, 2013 ; Olivry & Baumer, 2015 ; Pucheu‐Haston et al., 2015 ). Although environmental allergens such as indoor allergens, harmful dust, pollen, mould mites and grass play an important role in the aetiology of atopic dermatitis, it was reported that consumed allergenic foods also predispose to the disease (Bizikova et al., 2015 ; Pucheu‐Haston et al., 2015 ).…”

“…In the chronic phase, trefoil factors (TFF‐1, 2 and 3) are peptides that play a role in the protection and repair of epithelial surfaces, including the gastrointestinal tract (Aamann et al., 2017 ). Also, as a result of the organism's type 1 hypersensitivity response to environmental allergens in atopic dermatitis, a significant increase in IL‐4 and IL‐13 concentrations in addition to intense IgE production has been reported (Chaudhary et al., 2019 ; Maden et al., 2013 ; Majewska et al., 2016 )…”

“…with immunoglobulin E (IgE) antibodies formed in the skin or in the blood circulation against environmental antigens (Maden et al, 2013;Olivry & Baumer, 2015;Pucheu-Haston et al, 2015). Although environmental allergens such as indoor allergens, harmful dust, pollen, mould mites and grass play an important role in the aetiology of atopic dermatitis, it was reported that consumed allergenic foods also predispose to the disease (Bizikova et al, 2015;Pucheu-Haston et al, 2015).…”

“…In the chronic phase, trefoil factors (TFF-1, 2 and 3) are peptides that play a role in the protection and repair of epithelial surfaces, including the gastrointestinal tract (Aamann et al, 2017). Also, as a result of the organism's type 1 hypersensitivity response to environmental allergens in atopic dermatitis, a significant increase in IL-4 and IL-13 concentrations in addition to intense IgE production has been reported (Chaudhary et al, 2019;Maden et al, 2013;Majewska et al, 2016) In recent years, it has been established in human medicine that chronic intestinal diseases (such as irritable colon syndrome, Crohn's disease and celiac disease) predispose to dysbiosis as a result of disruption of the intestinal microbiota or leaky gut by causing damage to the intestinal wall and that this condition may form the basis of the development of atopic dermatitis. However, no studies have been conducted to determine whether there is an association between atopic dermatitis and intestinal damage in dogs.…”