Concentrations of some antibiotics in synovial fluid after oral administration, with special reference to antistaphylococcal activity.

Sattar, M. A.; Barrett, Stephen; Cawley, M. I. D.

doi:10.1136/ard.42.1.67

Cited by 34 publications

(12 citation statements)

References 27 publications

(5 reference statements)

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“…As we have discussed elsewhere bactericidal antibiotic concentrations should be achieved in the synovial fluid and in the serum. 22 The use of intra-articular antibiotics and surgical drainage did not confer any benefit, though these measures were often employed in patients with hip infections (a group biased for other reasons towards a poor prognosis).…”

Section: Discussionmentioning

confidence: 99%

Bacterial arthritis in an English health district: a 10 year review.

Cooper¹,

Cawley²

1986

Annals of the Rheumatic Diseases

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180

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Section: Discussionmentioning

confidence: 99%

Bacterial arthritis in an English health district: a 10 year review.

Cooper¹,

Cawley²

1986

Annals of the Rheumatic Diseases

Self Cite

180

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“…In all cases of possible bacterial joint infection, meticulous investigation to detect infection is mandatory. If infection is con firmed, the rigorous guidelines for monitor ing therapy advocated elsewhere [5,20] should be followed until clinical and micro biological cure is achieved. The serious re sults of occult infection in the hip have led us to aspirate this under radiological image in tensification to ensure accurate penetration of the joint cavity, when any possibility of infection exists [3].…”

Section: Discussionmentioning

confidence: 99%

Bacterial Arthritis in the Elderly

Cooper¹,

Cawley²

1986

Gerontology

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The clinical and microbiological features of bacterial arthritis in 21 elderly patients presenting to hospitals in an English health district over the decade 1973–1982 are reviewed. Differences from bacterial arthritis in younger patients include the high prevalence (71 %) of underlying joint disease, infections more commonly affecting the hip (38%), absence of constitutional features of toxaemia and delay in diagnosis. Outcome in elderly patients is markedly worse, with an appreciable mortality attributable to the condition.

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“…Most antibiotics achieve excellent bactericidal concentrations in synovial fluid following parenteral or oral administration (116,151). Intra-articular antimicrobial administration is usually not necessary and may cause a chemical synovitis.…”

Section: Antibiotic Therapymentioning

confidence: 99%

Acute Septic Arthritis

2002

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Acute septic arthritis may develop as a result of hematogenous seeding, direct introduction, or extension from a contiguous focus of infection. The pathogenesis of acute septic arthritis is multifactorial and depends on the interaction of the host immune response and the adherence factors, toxins, and immunoavoidance strategies of the invading pathogen. Neisseria gonorrhoeae and Staphylococcus aureus are used in discussing the host-pathogen interaction in the pathogenesis of acute septic arthritis. While diagnosis rests on isolation of the bacterial species from synovial fluid samples, patient history, clinical presentation, laboratory findings, and imaging studies are also important. Acute nongonococcal septic arthritis is a medical emergency that can lead to significant morbidity and mortality. Therefore, prompt recognition, rapid and aggressive antimicrobial therapy, and surgical treatment are critical to ensuring a good prognosis. Even with prompt diagnosis and treatment, high mortality and morbidity rates still occur. In contrast, gonococcal arthritis is often successfully treated with antimicrobial therapy alone and demonstrates a very low rate of complications and an excellent prognosis for full return of normal joint function. In the case of prosthetic joint infections, the hardware must be eventually removed by a two-stage revision in order to cure the infection

show abstract

Concentrations of some antibiotics in synovial fluid after oral administration, with special reference to antistaphylococcal activity.

Cited by 34 publications

References 27 publications

Bacterial arthritis in an English health district: a 10 year review.

Bacterial arthritis in an English health district: a 10 year review.

Bacterial Arthritis in the Elderly

Acute Septic Arthritis

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