1984
DOI: 10.1016/0048-9697(84)90039-1
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Concentrations of nitrates in drinking water and incidence of gastric carcinomas: First descriptive study of the piemonte region, Italy

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Cited by 69 publications
(35 citation statements)
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“…Elevated levels of methaemoglobin concentrations were found in Russia, in children who drank water containing as much as 182 mg l" 1 N0 3 (Handa, 1989). In Colombia and Italy, high levels of nitrate in well waters were associated with an increased risk of gastric cancer (Cuello et al, 1976;Gilli et al, 1984). In a cross-sectional study in an area with a high incidence of gastric cancer in northeastern China, an association was observed between high levels of nitrate in drinking water supplies and neoplastic changes in the stomach (Xu et al, 1992).…”
Section: Introductionmentioning
confidence: 99%
“…Elevated levels of methaemoglobin concentrations were found in Russia, in children who drank water containing as much as 182 mg l" 1 N0 3 (Handa, 1989). In Colombia and Italy, high levels of nitrate in well waters were associated with an increased risk of gastric cancer (Cuello et al, 1976;Gilli et al, 1984). In a cross-sectional study in an area with a high incidence of gastric cancer in northeastern China, an association was observed between high levels of nitrate in drinking water supplies and neoplastic changes in the stomach (Xu et al, 1992).…”
Section: Introductionmentioning
confidence: 99%
“…After gastrointestinal resorption and recirculation of foodborne nitrate, reduction to nitrite occurs in the oral cavity by bacterial activity, and carcinogenic N-nitroso compounds may subsequently be synthesized in the stomach from reingested nitrite and secondary amines also present in food. However, epidemiological studies have presented conflicting evidence to support this hypothesis: both inverse or absent associations (6)(7)(8)(9)(10) and positive correlations (9,(11)(12)(13)(14) have been reported, the latter indicating an increased stomach cancer risk at nitrate drinking water levels of 20 to 30 mg/L (11,13). The WHO concluded (S) that no firm epidemiological evidence has been provided to link increased incidence ofgastric cancer to high nitrate levels in drinking water.…”
Section: Introductionmentioning
confidence: 95%
“…Table 1 indicates that 72.3% and 29.8% of the samples for nitrate and nitrite concentrations exceed the desirable limit of 5.0 and 0.01 mg/L, respectively. High nitrate values can cause blue baby disease or methemoglobinemia in children, and nitrite is more toxic to public health than nitrate [8,34]. The above analysis demonstrates that these hydrochemical variables (barium, molybdenum, chromium, arsenic, mercury, fluoride, nitrate, and nitrite) have the significant impact on human and animal health, which should be given the highest weight coefficient of 5 in this article.…”
Section: Suitability For Drinkingmentioning
confidence: 99%