Concentrations of Lead in Bone in Plumbism

Westerman, Maxwell P.; Pfitzer, Emil A.; Ellis, Lawrence D.; Jensen, Wallace N.

doi:10.1056/nejm196512022732304

Cited by 46 publications

(10 citation statements)

References 15 publications

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“…The T V2(2) (ie, elimination from the skeleton) of five years reported in the present investigation is faster than most earlier estimates of the half-time of skeletal lead (8-71 years) by different techniques (6, 18,23,30,35,51 ,62,63,66). However , it is in accordance with data from some other studies (3,17,25,68,72,73). In addition it fits remarkably well the results of repeated X-ray fluorescence measurements of finger bone lead in ex-lead workers [a few of whom are identical with the present subjects (15, 61)} .…”

Section: Discussionsupporting

confidence: 92%

Kinetics of lead in blood after the end of occupational exposure.

Schütz¹,

Skerfving²,

Ranstam³

et al. 1987

Scand J Work Environ Health

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Section: Discussionsupporting

confidence: 92%

Kinetics of lead in blood after the end of occupational exposure.

Schütz¹,

Skerfving²,

Ranstam³

et al. 1987

Scand J Work Environ Health

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“…The rest must have been retained in the body in a slow compartment, mainly in the bone. The lead content of the skeleton is -even in occupationally nonexposed subjects -relatively high (4,26,37) when it is compared to the amount that could possibly have been retained in this study. Thus, when the analytical method errors are considered, no significant persistent elevation of PbB as a result of a small increase of lead in the skeleton should be expected after the lead contents of the rapid compartments have decayed.…”

Section: Ala In Urine Coproporphyrin In Urinementioning

confidence: 65%

Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects.

Schütz¹,

Skerfving²

1976

Scand J Work Environ Health

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Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects. by Schütz A, Skerfving S Key terms: blood; blood lead; blood lead level; coproporphyrin; dehydratase activity; delta-aminolevulinic acid; delta-aminolevulinic acid coproporphyrin; delta-aminolevulinic acid dehydratase activity; erythrocyte; excretion; experimental exposure; exposure; follow up; half-time; heavy exposure; lead; lead dust; male subject; man; short exposure; urinary excretion; urine This article in PubMed: www.ncbi.nlm.nih.gov/pubmed/788149 Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte c5 -'aminolevulinic acid dehydratase activity and urinary excretion of lead, c5 -aminolevulinic acid and coproporphyrin Results of a 6-month follow-up of two male subjects! by ANDREJS SCHUTZ, B.Sc., and STAFFAN SKERFVING, M.D.2 SCHaTZ, A. and SKE'RFVING, S. Effect of a short heavy exposure to lead dust upon blood lead level, erythrocyte o-aminolevulinic acid dehydratase activity and urinary excretion of lead, o-aminolevulink acid and coproporphyrin: Results of a 6-month follow-up of two marre subjects. Scand. j. work environ. & heaLth 3 (1976) 176-184. During 1 h two healthy volunteers, not earlier exposed occupationally to lead, inhaled about 100 mg of lead as a mixture of lead oxides and lead sulfate. Maximum blood lead (PbB) concentrations of about 0.5 mg/l and minimum blood cell o-aminolevulinic acid dehydratase activities (ALAD) (6 Ofo of the preexposure values) were observed within 38 h after exposure. PbB and ALAD returned to preexposure levels after about 300 and 150 days. A highly significant correlation between ALAD and PbB was seen even at lead levels in the range 0.1-0.2 mg/l. Delta-aminolevulinic acid, coproporphyrin and lead in the urine (ALAU, CPU, and PbU, respectively) increased. The peak levels occurred after about 15 h for ALAU and CPU and after about 24 h for PbU. There was a very good correlation between log PbU and lin PbB. ALAU increased already at PbB levels of about 0.3 mg/l.

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“…Moreover, the concentration of lead found in different soft tissues varies considerably after a dose of 210Pb, renal tissue having a considerably higher concentration than other tissues (liver, lung, spleen, heart, and striated muscle). In addition, the concentration of lead in the bone marrow is many times higher than the blood lead concentration (Westerman, Pfitzer, Ellis, and Jensen, 1965). It is likely to be the concentrations of lead in the liver and the bone marrow which will be the most important in determining the development of anaemia since these are the sites respectively of porphyrin synthesis and haemoglobinization of the red cell, and it may be seen from the equation above that these concentrations cannot be predicted accurately from a knowledge of the blood lead concentration as the value of A may be constant despite considerable variation in the values in the right-hand bracket.…”

Section: Relationship Between Tests Of Absorption and Intoxicationmentioning

confidence: 99%

Correlation between some parameters of lead absorption and lead intoxication

Waldron

1971

Occupational and Environmental Medicine

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Waldron, H. A. (1971).Brit. J. industr. Med.,28, 195-199. Correlation between some parameters of lead absorption and lead intoxication. Use has been made of data collected over a number of years from workers exposed to a lead hazard in a motor-car factory. The correlations between various parameters of lead absorption and lead intoxication were computed, including blood and urine lead concentrations, urinary coproporphyrin, ALA and PBG concentrations, and haemoglobin concentration. In all, 15 correlation coefficients were calculated, of which only six showed a statistically significant result (i.e., P<0·05). These six were blood lead and urine lead (r = 0·38, P<0·001), urine lead and coproporphyrin (r = 0·42, P<0·001), urine lead and ALA (r = 0·43, P<0·001), coproporphyrin and ALA (r = 0·75, P<0·001), ALA and PBG (r = 0·49, P<0·001), and urine lead and PBG (r = 0·19, P<0·05).

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Concentrations of Lead in Bone in Plumbism

Cited by 46 publications

References 15 publications

Kinetics of lead in blood after the end of occupational exposure.

Kinetics of lead in blood after the end of occupational exposure.

Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects.

Correlation between some parameters of lead absorption and lead intoxication

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