Concentrations of isoflavones in plasma and urine of post-menopausal women chronically ingesting high quantities of soy isoflavones

Mathey, Jacinthe; Lamothe, Valérie; Coxam, Véronique; Potier, M.; Sauvant, Patrick; Pelissero, C.

doi:10.1016/j.jpba.2006.01.051

Cited by 55 publications

(69 citation statements)

References 64 publications

(90 reference statements)

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“…In each country, daidzein concentrations in plasma were lower than those of genistein which refl ect the ingested proportions and the reverse was observed in the urine samples. This is in accordance with previous studies undertaken on humans and rats (Setchell et al 2003;Mathey et al 2006) showing that daidzein excretion is higher than that of genistein. This phenomenon refl ects a greater bioavailability of daidzein.…”

Section: Discussionsupporting

confidence: 93%

Food matrix and isoflavones bioavailability in early post menopausal women: An European clinical study

Chanteranne

Branca²,

Kaardinal³

et al. 2008

CIA

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Abstract:The estrogenic effects of soy isofl avones (IF) on symptoms of menopause are of particular interest. The aim of the present study was to improve compliance of IF in two IF-enriched foods providing the same IF circulating levels in postmenopausal women. Forty-two healthy postmenopausal women (mean age: 53.28 years) were recruited for a randomized, crossover, multicenter trial conducted in the Netherlands, Italy and France. Over 18 days, volunteers were assigned to two groups and supplemented with two different IF-enriched foods (100 mg IF aglycones/two servings). The fi rst group had to eat two biscuits daily for three days. After a wash-out period (11 d), they received cereal bars for three days. The second group started with the cereal bars and fi nished with biscuits. After IF intake, plasma and urinary levels of genistein, daidzein, O desmethyl angolensin and equol signifi cantly increased and returned to baseline level after the washout period. There was no difference between biscuits and cereals bars intake, as shown by group values at each end of experimental period (day 4 or day 18). Both matrixes are comparable in terms of IF-circulating levels and could be used independently.

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Section: Discussionsupporting

confidence: 93%

Food matrix and isoflavones bioavailability in early post menopausal women: An European clinical study

Chanteranne

Branca²,

Kaardinal³

et al. 2008

CIA

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“…Serum concentrations of GEN, DAI, or EQ are quite different between women from various geographic areas and/or specific diets [12]. For instance, isoflavones concentrations in plasma from 0.2 to 10 lM have been reported [2,13]. This is also in accordance with the fact that the relative binding affinity of phytoestrogens, measured on recombinant ER, is generally in the order of 1000-10 000 times less than that of E2 (except for GEN which has a much higher relative binding affinity in the order of 10-100 times less than E2) [3].…”

Section: Resultsmentioning

confidence: 99%

Respective contribution exerted by AF‐1 and AF‐2 transactivation functions in estrogen receptor α induced transcriptional activity by isoflavones and equol: Consequence on breast cancer cell proliferation

Carreau

Flouriot

Bennetau-Pelissero

et al. 2009

Molecular Nutrition Food Res

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Estrogens used in hormone replacement therapy regimens may increase the risk of developing breast cancer. Paradoxically, high consumption of plant-derived phytoestrogens, particularly soybean isoflavones, is associated with a low incidence of breast cancer. To explore the molecular basis for these potentially different experimental/clinical outcomes, we investigated whether soybean isoflavones elicit distinct transcriptional actions from estrogens by performing transient transfections in different cell lines. Our results demonstrate that 17beta estradiol (E2), isoflavones, and equol (EQ) effectively trigger the transcriptional activation with both estrogen receptors (ER), ER alpha and ER beta. ER alpha transcriptional activity is mediated through two transactivation domains AF-1 and AF-2, whose activity is tightly regulated in a cell-type and promoter-specific manner. Isoflavones, genistein, and daidzein (DAI), and EQ, the main estrogenic metabolite of DAI, are ER alpha agonists for transcriptional activation. The molecular mechanisms for ER alpha-induced transcriptional activity by isoflavones and EQ involve their capacity to act mainly through AF-1 regardless of the cell type. Therefore, our data indicate that estrogenic ligands, such as isoflavones and EQ, exert their effects on ER alpha transactivation similarly to the endogenous ligand E2, and suggest that the risk of estrogen-related diseases might not be reduced by soy-rich food and/or isoflavone- or EQ-based supplements.

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“…Although biflavonoids are known to display a variety of biological activities, such as anti-inflammatory activity, inhibition of cytochrome P450 enzymes, and antiviral activity, their neuroprotective roles have not been known (7,9,16 SOD activity may reduce (1,4,6,14,20). Similarly, we found that the SOD activity in the SA and MP group was significantly increased in comparison to that of the control group.…”

Section: Caspase-3 Expression Of Sciatic Nerve Fibersmentioning

confidence: 50%

The axon protective effects of syringic acid on ischemia/reperfusion injury in a rat sciatic nerve model

Tokmak¹,

Şehitoğlu²,

Yüksel³

et al. 2015

Turkish Neurosurgery

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Concentrations of isoflavones in plasma and urine of post-menopausal women chronically ingesting high quantities of soy isoflavones

Cited by 55 publications

References 64 publications

Food matrix and isoflavones bioavailability in early post menopausal women: An European clinical study

Food matrix and isoflavones bioavailability in early post menopausal women: An European clinical study

Respective contribution exerted by AF‐1 and AF‐2 transactivation functions in estrogen receptor α induced transcriptional activity by isoflavones and equol: Consequence on breast cancer cell proliferation

The axon protective effects of syringic acid on ischemia/reperfusion injury in a rat sciatic nerve model

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