Concentrations of cylindrospermopsin toxin in water and tilapia fish of tropical fishponds in Egypt, and assessing their potential risk to human health

Mohamed, Zainal Abidin; Bakr, Asmaa

doi:10.1007/s11356-018-3581-y

Cited by 29 publications

(22 citation statements)

References 58 publications

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“…MCs were reported in Ethiopia [158], Algeria [159], Tanzania [160], Kenya [161], South Africa [162], Tunisia [163], Zimbabwe [164], Morocco [165], Uganda [166], Egypt [167], Nigeria [168] and Ghana [169]. CYNs were found in Egypt [170] and Nigeria [171]. NODs were reported in South Africa [172] and Nigeria [171].…”

Section: Distribution Of Cyanotoxinsmentioning

confidence: 99%

The Diversity of Cyanobacterial Toxins on Structural Characterization, Distribution and Identification: A Systematic Review

Liu

Yuan

et al. 2019

Toxins

126

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The widespread distribution of cyanobacteria in the aquatic environment is increasing the risk of water pollution caused by cyanotoxins, which poses a serious threat to human health. However, the structural characterization, distribution and identification techniques of cyanotoxins have not been comprehensively reviewed in previous studies. This paper aims to elaborate the existing information systematically on the diversity of cyanotoxins to identify valuable research avenues. According to the chemical structure, cyanotoxins are mainly classified into cyclic peptides, alkaloids, lipopeptides, nonprotein amino acids and lipoglycans. In terms of global distribution, the amount of cyanotoxins are unbalanced in different areas. The diversity of cyanotoxins is more obviously found in many developed countries than that in undeveloped countries. Moreover, the threat of cyanotoxins has promoted the development of identification and detection technology. Many emerging methods have been developed to detect cyanotoxins in the environment. This communication provides a comprehensive review of the diversity of cyanotoxins, and the detection and identification technology was discussed. This detailed information will be a valuable resource for identifying the various types of cyanotoxins which threaten the environment of different areas. The ability to accurately identify specific cyanotoxins is an obvious and essential aspect of cyanobacterial research.

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Section: Distribution Of Cyanotoxinsmentioning

confidence: 99%

The Diversity of Cyanobacterial Toxins on Structural Characterization, Distribution and Identification: A Systematic Review

Liu

Yuan

et al. 2019

Toxins

126

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“…In O. niloticus, animals sampled at fish pounds in Egypt accumulated up to 1.5 μg g −1 of CYN in their livers. 20 For this same species, a strongest immunolocalization of CYN in the liver was detected, and the immunolabeling was intensified over time after exposure, demonstrating the biocamulation and toxicity of CYN in the liver of animals after acute and sub-chronic CYN-exposure. 26 For H. malabaricus, in animals exposed to a single intraperitomial injection (50 μg k −1 ) of aqueous extract of CYN-producing cyanobacteria, on average 6.79 and 5.61 ng g −1 of CYN was detected in the liver, after 7 and 14 days of exposition, respectively.…”

Section: Discussionmentioning

confidence: 77%

“…Considering fish species, a few data about CYN bioaccumulation and possible effects on liver is available. In O. niloticus , animals sampled at fish pounds in Egypt accumulated up to 1.5 μg g −1 of CYN in their livers 20 . For this same species, a strongest immunolocalization of CYN in the liver was detected, and the immunolabeling was intensified over time after exposure, demonstrating the biocamulation and toxicity of CYN in the liver of animals after acute and sub‐chronic CYN‐exposure 26 .…”

Section: Discussionmentioning

confidence: 97%

“…Accordingly, this group of vertebrates is relevant to study the potential toxicological effects of cyanotoxins in aquatic organisms. In Oreochromis niloticus (Cichliformes Order), a field study demonstrated that CYN are accumulated in intestine, liver and edible muscles, 20 but, in this case, only these three organs were analyzed. Others studies in O. niloticus have demonstrated that the pure or bacterial‐derived CYN promotes oxidative stress and also histophatological changes in many organs as liver, head kidney, heart, gills, and intestine 21‐23 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

DNA damage induced by cylindrospermopsin on different tissues of the biomonitor fish Poecilia reticulata

Rabelo

Hanusch

Jesus

et al. 2021

Environmental Toxicology

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The cyanotoxin cylindrospermopsin (CYN) is the second biggest cause of poisoning worldwide, both in humans and animals. Although CYN primarily affects the aquatic environments and can be absorbed in fishes by multiple routes, data reporting its toxicity and mechanism of action are still scarce in this group. Using P. reticulata as model species, it was evaluated whether CYN promotes mutagenic and genotoxic effects in different fish target tissues. Adult females were exposed in a static way to 0 (control), 0.5, 1.0, and 1.5 μg L −1 of pure CYN for 24 and 96 hours. For the first time, DNA damage was detected in fish brain after CYN exposition. In brain cells, a concentrationresponse DNA damage was observed for both exposure times, suggesting a direct or indirect action of CYN in neurotoxicity. For the liver cells, 96 hours caused an increase in DNA damage, as well the highest percentage of DNA in the tail was reached when used 1.5 μg L −1 of CYN. In peripheral blood cells, an increase in DNA damage was observed for all tested concentrations after 96 hours. In erythrocytes, micronuclei frequency was higher at 1.5 μg L −1 treatment while the erythrocyte nuclear abnormalities (ENA) frequency was significantly higher even at the lowest CYN concentration. Such data demonstrated that acute exposition to CYN promotes genotoxicity in the brain, liver, and blood cells of P. reticulata, as well mutagenicity in erythrocytes. It rises an alert regarding to the toxic effects of CYN for aquatic organisms as well as for human health.

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“…The intensity and frequency of cyanobacterial blooms have increased globally, particularly in reservoirs (Paerl 2018) and aquaculture ponds (Sevrin-Reyssac and Pletikosic 1990;Merel et al 2013;Mohamed and Bakr 2018), which have longer water retention times that favor eutrophication. In Brazil, toxic blooms of cyanobacteria are associated with tilapia production in net tanks (Borges et al 2010), leading to muscle contamination from saxitoxins (STXs; Galvão et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Exposure of Nile Tilapia (Oreochromis niloticus) Fingerlings to a Saxitoxin‐Producing Strain of Raphidiopsis (Cylindrospermopsis) raciborskii (Cyanobacterium) Reduces Growth Performance and Increases Mortality Rate

Bock

Moraes

Almeida

et al. 2020

Enviro Toxic and Chemistry

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Blooms of toxin‐producing cyanobacteria have been more frequent and lasting because of the eutrophication of freshwater ecosystems, including those used for aquaculture. The aim of the present study was to investigate the effects of chronic exposure to a saxitoxin‐producing strain of Raphidiopsis (Cylindrospermopsis) raciborskii on the performance of Nile tilapia (Oreochromis niloticus) fingerlings over a 60‐d period. The fingerlings were cultivated under the following conditions: 1) water without cyanobacterium (WATER), 2) R. raciborskii in ASM‐1 culture medium (CYANO), and 3) ASM‐1 culture medium without cyanobacterium (ASM). Exposure to the CYANO treatment led to a significant increase in the mortality rate (p < 0.05) and a significant reduction in growth (p < 0.05) compared to fingerlings submitted to the ASM and WATER treatments, in which similar survival and growth were found (p > 0.05). Saxitoxin toxicity was dependent on the weight of the fingerling (p < 0.05), with maximum mortality caused by the ingestion of 13.66 μg saxitoxin equivalent L−1 g−1. The present results clearly show the harm caused by saxitoxins to the production of Nile tilapia fingerlings in the early growth phase. These findings underscore the importance of maintaining adequate water quality in aquaculture activities to minimize the risk of saxitoxin‐producing cyanobacterial blooms and avoid economic losses among producers. Environ Toxicol Chem 2020;39:1409–1420. © 2020 SETAC

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Concentrations of cylindrospermopsin toxin in water and tilapia fish of tropical fishponds in Egypt, and assessing their potential risk to human health

Cited by 29 publications

References 58 publications

The Diversity of Cyanobacterial Toxins on Structural Characterization, Distribution and Identification: A Systematic Review

The Diversity of Cyanobacterial Toxins on Structural Characterization, Distribution and Identification: A Systematic Review

DNA damage induced by cylindrospermopsin on different tissues of the biomonitor fish Poecilia reticulata

Exposure of Nile Tilapia (Oreochromis niloticus) Fingerlings to a Saxitoxin‐Producing Strain of Raphidiopsis (Cylindrospermopsis) raciborskii (Cyanobacterium) Reduces Growth Performance and Increases Mortality Rate

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