Concentrations of cefixime in bronchial mucosa and sputum.

Sputum antibiotic concentrations: Implications for treatment of cystic fibrosis lung infection

“…The present study has shown that the key target PDIs associated with clinical effectiveness for ceftazidime and tobramycin were not achieved simultaneously or even independently at the site of infection in the lungs of CF patients following parenteral administration. The achievement of these specific PDIs, which are determined by the susceptibility of the infecting bacteria and the concentrations of antibiotics achieved at the site of infection, can be used to predict the success of antibiotic therapy with a number of studies of other lung infections such as pneumonia and bronchitis 23,24 suggesting that antibiotic concentrations achieved in the lung are important predictors for the outcome of treatment. As the infecting bacteria are found within the bronchial secretions in the lungs 11,12 of CF patients with pulmonary infection, the concentration of antibiotics achieved within these secretions may be more relevant than the concentration achieved in serum when calculating PDIs.…”