Concentrations of Calcitonin Gene-Related Peptide and Neuropeptide Y in Plasma Increase During Flushes in Postmenopausal Women

Wyon, Yvonne; Spetz, Anna-Clara; Theodorsson, G. Elvar; Hammar, Mats

doi:10.1097/00042192-200007010-00005

Cited by 63 publications

(46 citation statements)

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“…This in contrast to the results from menopausal women [14][15][16] and according to one study of men castrated due to prostate cancer [10].…”

Section: Discussioncontrasting

confidence: 92%

“…However, we dimensioned the study based on our former studies on women and men deprived of sex-steroids [10,16]. Unfortunately, we also had problems with the SC recordings due to computer disc crashes.…”

Section: Discussionmentioning

confidence: 99%

“…When CGRP is administrated intravenously to healthy male volunteers it produces symptoms very similar to hot flushes, with a dose-dependent increase in cutaneous blood flow [13]. CGRP increases in plasma during hot flushes in menopausal women [14][15][16] and according to one study, in men with flushes who had been castrated due to prostate cancer [10]. No relation has been reported between flushes and CGRP in non-castrated aging men, but flushes in these men have not been given much attention.…”

Section: Introductionmentioning

confidence: 99%

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Hot flushes in healthy aging men differ from those in men with prostate cancer and in menopausal women

Holm

Thorell

Theodorsson

et al. 2011

Gynecological Endocrinology

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Abstract:Calcitonin Gene-Related Peptide (CGRP) seems to be involved in hot flushes in women and in castrated men. Therefore, we studied whether the plasma concentrations of CGRP changed during flushes in a group of healthy aging men. Twelve men (49-71 years) with no history of current or former prostate cancer or hormonal treatment reporting ≥20 flushes/week were investigated. Blood samples were drawn during and between flushes for analysis of CGRP and also androgen concentrations, i.e. Testosterone and Bioavailable Testosterone were analysed.Skin temperature and skin conductance were monitored.

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“…This in contrast to the results from menopausal women [14][15][16] and according to one study of men castrated due to prostate cancer [10].…”

Section: Discussioncontrasting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hot flushes in healthy aging men differ from those in men with prostate cancer and in menopausal women

Holm

Thorell

Theodorsson

et al. 2011

Gynecological Endocrinology

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show abstract

“…Calcitonin gene related peptide (CGRP) is released into the circulation during a hot flush. 50 Acupuncture causes the release of ß-endorphin which has an inhibitory effect on CGRP. Wyon and colleagues showed that the urinary excretion of CGRP was reduced with acupuncture ( Figure 2).…”

Section: Figure 1 This Is An Algorithm For Long Term Treatment With Amentioning

confidence: 99%

“…At three month follow up assessment, the superficial treatment tended to experience more flushes than the EA group. Interestingly the urinary excretion of calcitonin gene related peptide (CGRP), a powerful vasodilator that is released during a hot flush, 50 also decreased over the treatment period. 40 Asecond RCT by Sandberg et al 2002 in patients experiencing symptoms from the natural climacteric also compared EA with superficial treatment.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture and Self Acupuncture for Long Term Treatment of Vasomotor Symptoms in Cancer Patients - Audit and Treatment Algorithm

Filshie

Bolton²,

Browne

et al. 2005

Acupunct Med

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Introduction Since hormone replacement therapy given for long periods is now recognised to produce serious side effects, patients with troublesome vasomotor symptoms are increasingly using non-hormonal treatment including acupuncture. Several randomised controlled trials have shown that acupuncture reduces menopausal symptoms in patients experiencing the normal climacteric. It may have this effect by raising serotonin levels which alter the temperature set point in the hypothalamus. Va somotor symptoms can be extreme in breast cancer patients and patients with prostate cancer who are undergoing anticancer therapy. The safety of some herbal medicines and phytoestrogens has been questioned, as they could potentially interfere adversely with the bioavailability of tumouricidal drugs. Aprevious study reports short term benefit from acupuncture, and the aim of this report is to describe our approach to long term treatment. Acupuncture approach After piloting several approaches, six weekly treatments were given initially at LI4, TE5, LR3 and SP6 and two upper sternal points, but avoiding any limb with existing lymphoedema or prone to developing it. If there were no contraindications, patients were given clear instructions on how to perform self acupuncture using either semi-permanent needles or conventional needling at SP6, weekly for up to six years, for long term maintenance. Audit methods and results Aretrospective audit of electronic records was carried out by a doctor not involved in treatment. Atotal of 194 patients were treated, predominantly with breast and prostate cancer. One hundred and eighty two patients were female. The number of pre-treatment hot flushes per day was estimated by the patient: in the 159 cases providing adequate records, the mean was 16 flushes per day. Following treatment, 114 (79%) gained a 50% or greater reduction in hot flushes and 30 (21%) a less than 50% reduction. Treatment was abandoned in those who responded poorly or not at all. The duration of treatment varied from one month to over six years with a mean duration of nine months. Seventeen patients (9%) experienced minor side effects over the six year period, mostly minor rashes; one patient described leg swelling but this was likely to be due to a concurrent fracture. Conclusion Acupuncture including self acupuncture is associated with long term relief of vasomotor symptoms in cancer patients. Treatment is safe and costs appear to be low. An algorithm is presented to guide clinical use. We recommend the use of self acupuncture with needles at SP6 in preference to semipermanent needles in the first instance, but poor responders use indwelling studs if they fail to respond adequately to self acupuncture with regular needles. Point location may be of less importance than the overall 'dose', and an appropriate minimum dose may be required to initiate the effect.

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Acupuncture in Oncology

D'Alessandro

2019

Translational Acupuncture Research

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Concentrations of Calcitonin Gene-Related Peptide and Neuropeptide Y in Plasma Increase During Flushes in Postmenopausal Women

Cited by 63 publications

References 0 publications

Hot flushes in healthy aging men differ from those in men with prostate cancer and in menopausal women

Hot flushes in healthy aging men differ from those in men with prostate cancer and in menopausal women

Acupuncture and Self Acupuncture for Long Term Treatment of Vasomotor Symptoms in Cancer Patients - Audit and Treatment Algorithm

Acupuncture in Oncology

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