Hot flushes in healthy aging men differ from those in men with prostate cancer and in menopausal women

Holm, Anna‐Clara Spetz; Thorell, Lars‐Håkan; Theodorsson, Elvar; Hammar, Mats

doi:10.3109/09513590.2011.588744

Cited by 2 publications

(1 citation statement)

References 32 publications

(37 reference statements)

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“…87 However, a study of aging men without cancer reporting hot flashes unrelated to surgery, cancer, or cancer treatment failed to find an association between plasma CGRP and hot flashes. 88 Work in this area needs to be replicated since findings might lead to new treatment options.…”

Section: Pathophysiologymentioning

confidence: 99%

Risk factors, pathophysiology, and treatment of hot flashes in cancer

Fisher

Johnson

Elkins

et al. 2013

CA A Cancer J Clinicians

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Hot flashes are prevalent and severe symptoms that can interfere with mood, sleep, and quality of life for women and men with cancer. The purpose of this article is to review existing literature on the risk factors, pathophysiology, and treatment of hot flashes in persons with cancer. Electronic searches were conducted to identify relevant, English-language literature published through June 15, 2012. Results indicated that risk factors for hot flashes in cancer include patient-related factors (eg, age, race/ethnicity, educational level, smoking history, cardiovascular risk including BMI, and genetics) and disease-related factors (eg, cancer diagnosis, and dose/type of treatment). In addition, although the pathophysiology of hot flashes has remained elusive, these symptoms are likely attributable to disruptions in thermoregulation and neurochemicals. Therapies that have been offered or tested fall into 4 broad categories: pharmacological, nutraceutical, surgical, and complementary/behavioral strategies. The evidence base for this broad range of therapies varies, with some treatments not yet having been fully tested or showing equivocal results. The evidence base surrounding all therapies is evaluated to enhance hot flash treatment decision making by clinicians and patients.

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Section: Pathophysiologymentioning

confidence: 99%