Concentration, spatial distribution, and health risk assessment of PFASs in serum of teenagers, tap water and soil near a Chinese fluorochemical industrial plant

Xie, Lin-Na; Wang, Xiaochen; Dong, Xiao-Jie; Su, Liqin; Zhu, Huijuan; Dianping, Zhang; Liu, Fangying; Hou, Sha-Sha; Dong, Bi Rong; Shan, Guoqiang; Zhang, Xu; Zhu, Ying

doi:10.1016/j.envint.2020.106166

Cited by 45 publications

(15 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 b, PFOA accounted for the largest proportion of risk among PFASs (89.4%), followed by PFOS (7.0%) and PFHxS (1.80%). PFASs in teenagers may influence the reproductive system and character development of residents living near a Chinese fluorine chemical plant, as shown previously 52 . Drinking water provides the major ingestion pathway for PFASs, and they have a long half-life in the human body.…”

Section: Resultssupporting

confidence: 62%

Multiple pollutants in groundwater near an abandoned Chinese fluorine chemical park: concentrations, correlations and health risk assessments

Tang

Zhu

Xiang

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Contamination and adverse effects from various pollutants often appear in abandoned industrial regions. Thus, nine groundwater samples were collected from the vicinity of the fluorochemical industry in Fuxin City, Liaoning Province, to determine concentrations of the ten heavy metals arsenic (As), chromium (Cr), cadmium (Cd), lead (Pb), nickel (Ni), copper (Cu), manganese (Mn), zinc (Zn), iron (Fe) and mercury(Hg), as well as those of fluorine (F−) and eighteen poly- and perfluorinated substances (PFASs), analyse correlation relationships, and assess the health risks for different age groups. The results showed that the levels of fluorine (F−) (0.92–4.42 mg·L−1), Mn (0.0005–4.91 mg·L−1) and Fe (1.45–5.61 mg·L−1) exceeded the standard limits for drinking water. Short chain perfluorobutanoic acid (PFBA) (4.14–2501.42 ng·L−1), perfluorobutane sulfonate (PFBS) (17.07–51,818.61 ng·L−1) and perfluorohexanoic acid (PFHxA) (0.47–936.32 ng·L−1) were the predominant substances from the PFASs group. No individual PFASs levels had significant relationships with F− or heavy metal contents. There was a positive relationship between short chain PFASs concentrations and water depth and a negative relationship between long chain PFASs concentration and water depth. The hazard quotient (HQ) decreased in the order F− > heavy metals > PFASs and also decreased for older age groups. In addition, As, Fe, Mn and perfluorooctanoic acid (PFOA) were the main sources of risk from the heavy metal and PFASs groups, respectively.

show abstract

Section: Resultssupporting

confidence: 62%

Multiple pollutants in groundwater near an abandoned Chinese fluorine chemical park: concentrations, correlations and health risk assessments

Tang

Zhu

Xiang

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The average HQ values of reproductive toxicity and hepatotoxicity of PFOA were 6.02 × 10 -4 and 5.75 × 10 -3 , respectively, and the average HQ values of reproductive toxicity and hepatotoxicity of PFBA were 6.68 × 10 -7 and 1.34 × 10 -6 , respectively, indicating that PFOA and PFBA didn't pose the health risk to the target area. Some researchers believed that the detection of PFOS and PFOA in soil and groundwater near a fluorine chemical plant in China poses a much greater health risk than other fluorinated compounds (Wei et al, 2018;Xie et al, 2021). PFOS can suppress sheep red blood cellspecific immunoglobulin M production on mice, and cause hepatocellular hypertrophy in livers of rats (Peden-Adams et al, 2008;Butenhoff et al, 2012), even caused the death of newborn mice (Yahia et al, 2010).…”

Section: Ecological Risk Assessmentmentioning

confidence: 99%

Occurrence and Risk Assessment of per- and Polyfluoroalkyl Substances in Water Source Protection Area of Southeastern China

Ren

2022

Front. Environ. Sci.

View full text Add to dashboard Cite

In order to clarify the pollution characteristics and human health risks of PFASs pollutants in typical drinking water sources in Zhejiang Province, this study relies on ultra -performance liquid chromatography-mass spectrometry (UPLC-MS/MS) technology to analyze the pollution of 26 PFASs in 7 reservoirs in Zhejiang Province. The detected concentrations of PFASs were evaluated to further assess the human health risks. Total PFASs concentrations in the seven reservoirs ranged from 1.30 ng L−1–24.90 ng L−1. Among the 26 PFASs pollutants analyzed, PFOA and PFBA were the main PFASs pollutants, the detected concentrations of PFOA and PFBS ranging from 0.50 ng L−1–13.70 ng L−1 and 0 ng L−1–1.70 ng L−1, respectively. Then we evaluated 15 PFASs and calculated the results of the HQ value of the reproductive toxicity and hepatotoxicity of the total PFASs in this study ranged from 2.30 × 10–8 to 1.16 × 10–4 and 9 × 10–8 to 5.24 × 10–4 respectively, which were both lower than 0.01, indicating that there is no significant risk to the human body.

show abstract

“…In general, environmental endocrine-disrupting chemicals have anti-androgenic effects that are mediated by mechanisms, such as interference with the androgen receptor, androgen production, metabolism, or signaling in the HPG axis [ 230 ]. Apart from making our daily life easier, plastic-originated agents and other endocrine-disrupting chemicals cause harm not only to the environment but also to the fertility and health of men.…”

Section: Environmental Factorsmentioning

confidence: 99%

“…Based on testosterone levels and E2, a correlation of PFOS and perfluorooctanoic acid (PFOA) levels with the delay of puberty in children (boys and girls) has also been demonstrated [ 234 ]. Higher levels of PFOS exposure are significantly associated with decreased serum testosterone concentrations in the male, which is age-specific and stronger in older men [ 230 ]. CYP11A1, a protein-coding gene, catalyzes the conversion of cholesterol to pregnenolone, and steroidogenesis starts with this reaction in all mammalian tissues [ 255 ].…”

Section: Environmental Factorsmentioning

confidence: 99%

Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction

et al. 2021

View full text Add to dashboard Cite

Hypogonadism is an endocrine disorder characterized by inadequate serum testosterone production by the Leydig cells of the testis. It is triggered by alterations in the hypothalamic–pituitary–gonadal axis. Erectile dysfunction (ED) is another common disorder in men that involves an alteration in erectile response–organic, relational, or psychological. The incidence of hypogonadism and ED is common in men aged over 40 years. Hypogonadism (including late-onset hypogonadism) and ED may be linked to several environmental factors-induced oxidative stresses. The factors mainly include exposure to pesticides, radiation, air pollution, heavy metals and other endocrine-disrupting chemicals. These environmental risk factors may induce oxidative stress and lead to hormonal dysfunctions. To better understand the subject, the study used many keywords, including “hypogonadism”, “late-onset hypogonadism”, “testosterone”, “erectile dysfunction”, “reactive oxygen species”, “oxidative stress”, and “environmental pollution” in major online databases, such as SCOPUS and PUBMED to extract relevant scientific information. Based on these parameters, this review summarizes a comprehensive insight into the important environmental issues that may have a direct or indirect association with hypogonadism and ED in men. The study concludes that environmental factors-induced oxidative stress may cause infertility in men. The hypothesis and outcomes were reviewed critically, and the mechanistic approaches are applied through oxidant-sensitive pathways. This study also provides reccomendations on future therapeutic interventions and protective measures against such adverse environmental factors-induced hypogonadism and ED.

show abstract

Concentration, spatial distribution, and health risk assessment of PFASs in serum of teenagers, tap water and soil near a Chinese fluorochemical industrial plant

Cited by 45 publications

References 46 publications

Multiple pollutants in groundwater near an abandoned Chinese fluorine chemical park: concentrations, correlations and health risk assessments

Multiple pollutants in groundwater near an abandoned Chinese fluorine chemical park: concentrations, correlations and health risk assessments

Occurrence and Risk Assessment of per- and Polyfluoroalkyl Substances in Water Source Protection Area of Southeastern China

Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction

Contact Info

Product

Resources

About