Concentration of lissamine green in proximal tubules of antidiuretic and mercury poisoned rats and the permeability of these tubules

Steinhausen, M.; Eisenbach, Georg-Michael; Helmstädter, V.

doi:10.1007/bf00588058

Cited by 60 publications

(17 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Four mechanisms have been implicated: (a) renal vasoconstriction, (b) development of an aglomerular shunt pathway, (c) tubular obstruction, and (d) back leakage of filtrate. Although observations have been made which could be compatible with the latter three possibilities (1)(2)(3)(4)(5)(6), the majority of recent data support alterations in renal resistance as the major determinant of diminished filtration in acute renal failure (7)(8)(9)(10)(11)(12). Data obtained from micropuncture and hemodynamic studies have led to the view that marked afferent arteriolar constriction decreases effective filtration pressure and glomerular filtration rate.…”

Section: Introductionmentioning

confidence: 97%

Studies on the Mechanism of Oliguria in a Model of Unilateral Acute Renal Failure

Cox¹,

Baehler²,

Sharma³

et al. 1974

J. Clin. Invest.

120

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 97%

Studies on the Mechanism of Oliguria in a Model of Unilateral Acute Renal Failure

Cox¹,

Baehler²,

Sharma³

et al. 1974

J. Clin. Invest.

120

View full text Add to dashboard Cite

“…According to that theory of the pathogenesis of acute renal failure, glomerular filtration is normal but the glomerular fil trate is almost quantitatively absorbed across damaged tubular epi thelium. Two recent micropuncturc studies of acute renal failure pro duced with low doses of HgCl2 lend support to that possibility [1,22]. The present experiments were designed to examine the effect of chro nic saline loading on the renal functional changes and histologic cor relates in rats poisoned with a comparable dosage of mercuric chloride.…”

mentioning

confidence: 99%

Maintenance of Renal Function in Salt Loaded Rats Despite Severe Tubular Necrosis Induced by HgCl<sub>2</sub>

DiBona

McDonald

Flamenbaum

et al. 1971

Nephron

110

View full text Add to dashboard Cite

Inulin and mannitol clearances, BUN concentrations and renal morphologic alterations were studied in rats 24 h after the injection of low doses of mercuric chloride. Water drinking rats given 4.7 mg/kg body weight of HgCl₂ developed renal failure and severe tubular necrosis. Their clearance of inulin was decreased to the same degree as their simultaneously determined mannitol clearance. Any significant change in tubular permeability should have resulted in a greater loss of mannitol than inulin, and it is suggested that tubular permeability to neither molecule was greatly increased. This is supported by the fact that rats drinking one percent saline in place of tap water for a month prior to receiving the same dose of HgCl₂ showed insignificant changes in inulin clearance and minimal elevations in BUN concentration. Nevertheless, histologic sections of their kidneys showed frank tubular necrosis that was equally severe as, but slightly less extensive than that observed in the water drinking rats whose inulin clearance was 6 % of normal. In view of these findings, it seems unlikely that alterationin tubular permeability per se are responsible for the development of acute renal failure in low dose mercury poisoning. The protective effect of salt loading does not depend on the prevention of tubular injury, and may well reflect inhibition of pre-glomerular vasoconstriction by suppression of the renin-angiotensin axis.

show abstract

“…However, the preponderance of evidence, mainly derived from micropuncture studies, favors the view that the major factor leading to oliguria in ARF is reduction of glomerular filtration rate per nephron, secondary to cortical hypoperfusion, the latter probably due to an increased preglomerular resistance (17)(18)(19)(20)(21). Opposed to this concept is the contention that structural and functional tubular changes are primarily responsible for the oliguria (22,23).…”

Section: Discussionmentioning

confidence: 99%

“…Because of the marked decrease in the filtration rate per nephron the phosphorus load which is delivered to the tubules may be well below the maximum reabsorptive capacity (TmPO4) leading to an almost complete reabsorption of the filtered phosphorus (26). tive mechanism responsible for oliguria (22,23) one may argue that the exceedingly low Cp/GFR reflects a passive back-flow of phosphorus across more severely injured epithelium. However, passive back-flow probably should not result in differential reabsorption of phosphorus and creatinine (inulin) to give very low Cp/GFR.…”

Section: Discussionmentioning

confidence: 99%

Renal handling of phosphorus in oliguric and nonoliguric mercury-induced acute renal failure in rats

Popovtzer¹,

Massry²,

Villamil³

1971

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T The renal handling of phosphorus was evaluated in rats with acute renal failure (ARF) induced by injection of mercuric chloride (HgCls). Clearances of endogenous creatinine (Ccr) and of phosphorus (Cp) were measured in the following groups: 1. Intact animals (control); 2. Parathyroidectomized rats (PTX) with normal kidney function (PTX control) Received for publication 8 December 1970 and in revised form 7 June 1971. P < 0.0005. In the nonoliguric ARF animals of group 4 the Cp/GFR 0.27 ±0.08 did not differ from the clearance ratio in group 1, however it was higher than that in the PTX animals (group 2) P < 0.0005. Cp/GFR in the nonoliguric animals of group 5 was not different from that in the nonoliguric rats of group 3. In the animals with nonoliguric unilateral Hg-ARF Cp/GFR on the affected side 0.51 ±0.16 was higher than that on the control (contralateral) side, 0.23 --0.07, P <0.0005.These results indicate that the low Cp/GFR observed in the oliguric ARF animals was not related to the level of circulating parathyroid hormone nor to the presence or absence of azotemia but probably was due to a reduced renal cortical perfusion. The high Cp/GFR in the nonoliguric ARF animals could be explained by secondary hyperparathyroidism and impaired phosphorus reabsorption due to tubular injury.

show abstract

Concentration of lissamine green in proximal tubules of antidiuretic and mercury poisoned rats and the permeability of these tubules

Cited by 60 publications

References 11 publications

Studies on the Mechanism of Oliguria in a Model of Unilateral Acute Renal Failure

Studies on the Mechanism of Oliguria in a Model of Unilateral Acute Renal Failure

Maintenance of Renal Function in Salt Loaded Rats Despite Severe Tubular Necrosis Induced by HgCl<sub>2</sub>

Renal handling of phosphorus in oliguric and nonoliguric mercury-induced acute renal failure in rats

Contact Info

Product

Resources

About