1974
DOI: 10.1172/jci107705
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Studies on the Mechanism of Oliguria in a Model of Unilateral Acute Renal Failure

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Cited by 120 publications
(37 citation statements)
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“…Cox et al have suggested such a mechanism in an ischemic model of renal failure (11). Also, in a recent report, Bennett and co-workers have shown a reduction in LpA while sngfr was unchanged in the early phase of acute experimental glomerulonephritis (27).…”
Section: Discussionmentioning
confidence: 95%
See 1 more Smart Citation
“…Cox et al have suggested such a mechanism in an ischemic model of renal failure (11). Also, in a recent report, Bennett and co-workers have shown a reduction in LpA while sngfr was unchanged in the early phase of acute experimental glomerulonephritis (27).…”
Section: Discussionmentioning
confidence: 95%
“…Recent studies on this issue (1-6) have suggested the following mechanisms leading to a reduction in measured filtration rate: (a) Renal vasoconstriction, which could decrease GFR by either a reduction in nephron plasma flow (rpf) or decrease the glomerular capillary hydrostatic pressure (Pa); (b) tubular obstruction may lead to a reduction in filtration by elevating tubular pressure and reducing the hydrostatic pressure gradient acting across the glomerular capillary membrane (AP) (4)(5)(6); and (c) transepithelial leak of solutes as large as inulin or lissamine green, as a result of epithelial injury, requiring no primary alteration in filtration at the glomerulus (7-9). The apparent disagreements which have arisen as to the exact mechanism for decreased GFR may have at least two explanations: (a) The experimental models which have been utilized differ rather markedly and (b) the experimental observations have been obtained at widely varied time intervals after the initial injury (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”
mentioning
confidence: 99%
“…The sequence of injection was alternated. Total RBF was measured using a modified indicator dilution technique with the microspheres as previously described and validated from this and other laboratories (11,14,15). Glomerular filtration rate (GFR) was estimated from the clearance of inulin.…”
Section: Methodsmentioning
confidence: 99%
“…In sodiumloaded rats, administration of UN did not significantly reduce GFR (Table IV) In glomerular capillaries, the total area of epithelial slit pores has been considered to be the major determinant of water permeability (8). In some models of acute renal failure epithelial alterations have been found and it has been suggested that these alterations may be responsible for the decline in glomerular Kf (4,5). However, several observations are against this possibility.…”
Section: Resultsmentioning
confidence: 99%
“…Reduction in ultrafiltration coefficient (Kf) of glomerular capillaries is one of the several abnormalities that has been identified in uranyl nitrate (UN)'-induced acute renal failure in rats (1)(2)(3)(4)(5)(6). However, the reason for the decline in glomerular capillary Kf is not understood.…”
Section: Introductionmentioning
confidence: 99%