Concentration of interleukin-1β correlates with prostaglandin E2 and F2α in human pre-ovulatory follicular fluid

Watanabe, Hiroyuki; Nagai, Kimihiro; Yamaguchi, Masatoshi; Ikenoue, Tsuyomu; Môri, N.

doi:10.1093/oxfordjournals.humrep.a138327

Cited by 18 publications

(12 citation statements)

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“…This effect may be triggered by sphingomyelin hydrolysis and ceramide production (Santana et al 1996). Finally, in vivo IL-1 concentration in human follicular fluid is correlated with PGE2 and PGF2 concentrations (Watanabe et al 1994). By using an ovarian perfusion model, Peterson et al (1993) confirmed these observations in the rat.…”

Section: Production and Activation Of Proteolytic Enzymesmentioning

confidence: 54%

“…Their results lead us to conclude that IL-1 intervenes in PG production, mainly by acting on cyclooxygenase-2 (COX-2) synthesis. Actually, IL-1 induces in vitro PGE2 and PGF2 production by granulosa cells (humans: Watanabe et al 1993;rats: Hurwitz et al 1995;cattle: Acosta et al 1998). Moreover, it has been demonstrated in vitro that IL-1 induces an increase in 6 keto-PGF1 , PGE2 and PGF2 in cultured rat preovulatory follicles (Brännström et al 1993b) and bovine granulosa cells (Nothnick & Pate 1990).…”

Section: Production and Activation Of Proteolytic Enzymesmentioning

confidence: 99%

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The interleukin-1 system and female reproduction

Gérard¹,

Caillaud²,

Martoriati³

et al. 2004

Journal of Endocrinology

148

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Interleukins (ILs) are known best for their involvement in the immune system and their role during inflammation. In the ovary, a growing body of evidence suggests that the ovarian follicle is a site of inflammatory reactions. Thus ovarian cells could represent sources and targets of ILs. Since then, the IL-1 system components (IL-1 , IL-1 , IL-1 receptor antagonist, IL-1 receptors) have been demonstrated to have several sites of synthesis in the ovary. These factors have been localized in the various ovarian cell types, such as the oocyte, granulosa and theca cells, in several mammalian species. IL-1-like bioactivity has been reported in human and porcine follicular fluid at the time of ovulation. The role of IL-1 in local processes is still poorly known, although there is evidence for involvement in the ovulation process, and in oocyte maturation. More precisely, IL-1 may be involved in several ovulationassociated events such as the synthesis of proteases, regulation of plasminogen activator activity, prostaglandin and nitric oxide production. IL-1 also regulates ovarian steroidogenesis. These different aspects of the involvement of the IL-1 system in important aspects of female reproduction are discussed.

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Section: Production and Activation Of Proteolytic Enzymesmentioning

confidence: 54%

Section: Production and Activation Of Proteolytic Enzymesmentioning

confidence: 99%

The interleukin-1 system and female reproduction

Gérard¹,

Caillaud²,

Martoriati³

et al. 2004

Journal of Endocrinology

148

View full text Add to dashboard Cite

show abstract

“…In particular, macrophages have been recognised for their role in inducing progesterone production in granulosa cells in coculture experiments in mice (Kirsch et al 1981), humans (Halme et al 1985) and pigs (Standaert et al 1990) without concomitant granulosa cell proliferation. Two potent cytokines secreted by macrophages, interleukin-1 and tumour necrosis factor-a, have been shown to stimulate both progesterone and prostaglandin synthesis (Nakamura et al 1990, Kokia et al 1992, Watanabe et al 1993, Brannstrom et al 1994, Roby et al 1999 and these may interact with other macrophage-derived factors to fine-tune gonadotrophin regulation of corpus luteum function and demise (Wuttke et al 1997). In vitro experiments from human granulosa cells further implicate cytokines originating from ovarian cells in promoting proliferation and/or functional activation of steroidogenic cells (Jasper et al 1996).…”

Section: S O'leary and Othersmentioning

confidence: 99%

Seminal plasma regulates ovarian progesterone production, leukocyte recruitment and follicular cell responses in the pig

O’Leary

Jasper²,

Robertson³

et al. 2006

Reproduction

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Seminal plasma (SP) acts to influence the uterine endometrium after mating, activating synthesis of embryotrophic cytokines and inflammatory changes that condition the tract for embryo implantation and establishing pregnancy. The objective of this study was to investigate in pigs whether the ovary might also be responsive to SP exposure. Prepubertal gilts were synchronised with exogenous gonadotrophins and received transcervical treatment with pooled boar SP or PBS; then the ovarian tissue was recovered at 34 h (preovulation) and on days 5 and 9 after treatment. The ovarian response was assessed by measuring ovulation rate, number and size of corpora lutea, ovarian leukocyte populations, progesterone production in vivo, as well as responses of retrieved granulosa cells cultured in vitro. In SP-treated gilts, leukocyte recruitment into the ovarian tissues was increased fourfold at 34 h, with macrophages comprising the most abundant cell lineage. There was no effect of SP on the number of oocytes ovulated; however, the weight of corpora lutea was increased in SP-treated gilts. SP also induced an increase in plasma progesterone content seen from day 5 to at least day 9 after treatment. In addition, granulosa cells and thecal tissue retrieved from preovulatory follicles of SP-treated gilts were more responsive in vitro to growth factor-and gonadotrophin-stimulated cell proliferation and progesterone synthesis. These results suggest that uterine exposure to SP influences immune cell trafficking in the ovary and enhances steroidogenesis in early pregnancy. The effects of SP on ovarian function potentially contribute to reproductive success in the pig.

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“…Furthermore, their production seems to be regulated by some cytokines, i.e., interleukin (IL)-I and tumor necrosis factor-tx (TNF-e0, because they can stimulate monocytes to produce PGs (6,7).…”

Section: Introductionmentioning

confidence: 99%