Concentration of heavy metals and rare earth elements in patients with brain tumours: Analysis in tumour tissue, non-tumour tissue, and blood

Găman, Laura; Rădoi, Mugurel; Delia, Corina; Luzardo, Octavio P.; Zumbado, Manuel; Rodríguez-Hernández, Ángel; Gîlcă, Marilena; Boada, Luís D.; Henríquez-Hernández, Luis Alberto

doi:10.1080/09603123.2019.1685079

Cited by 31 publications

(18 citation statements)

References 46 publications

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“…Thus, the presence of these elements into neurons, even at low concentrations, seems to be able to modify brain homeostasis. This is the case of gadolinium and tantalum whose tissue concentrations were higher among patients with brain cancer compared to a control group [18]. The aim of the present study was to evaluate the contribution of 45 inorganic elements-including trace elements, elements included in the priority list of substances of the Agency for Toxic Substances and Disease Registry (ATSDR), and REE and other elements used in electronic devices-as factors associated with stroke.…”

Section: Introductionmentioning

confidence: 93%

“…Elements of standard purity (5% HNO 3 , 100 mg/L) were purchased from CPA Chem (Stara Zagora, Bulgaria). Two standard curves (range = 0.005-20 ng/mL) were made: (a) one used a commercial multi-element mixture (CPA Chem Catalog number E5B8•K1.5N.L1, 21 elements) containing all the trace elements and the main heavy metals and (b) the other multi-element mixture included individual elements (CPA Chem) that contained the REEs and other elements used in electronic devices [18,19].…”

Section: Selection Of Elements and Sample Preparationmentioning

confidence: 99%

“…An Agilent 7900 ICP-MS (Agilent Technologies, Tokyo, Japan) was used for quantification. Instrument configuration and optimization were previously reported [18]. The elements were quantified in the MassHunter v.4.2.…”

Section: Analytical Proceduresmentioning

confidence: 99%

“…Although some of these elements are relatively abundant in the Earth's crust (i.e., cerium is as abundant as copper), REEs have been included among the new and emerging occupational and environmental health risks by several international organizations [17]. Different studies have shown that some of these elements have an adverse effect on people's health [18][19][20], although the mechanisms of action are not clear [17,21].…”

Section: Introductionmentioning

confidence: 99%

“…It has to be highlighted that some inorganic elements are neurological disruptors with the capacity to cross the blood brain barrier [18]. While small concentrations of some elements are needed for life, most are considered non-essential and some are very toxic even at very low concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Association between Heavy Metals and Rare Earth Elements with Acute Ischemic Stroke: A Case-Control Study Conducted in the Canary Islands (Spain)

Medina-Estévez

Zumbado

Luzardo

et al. 2020

Toxics

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The role of inorganic elements as risk factors for stroke has been suggested. We designed a case-control study to explore the role of 45 inorganic elements as factors associated with stroke in 92 patients and 83 controls. Nineteen elements were detected in >80% of patients and 21 were detected in >80% of controls. Blood level of lead was significantly higher among patients (11.2 vs. 9.03 ng/mL) while gold and cerium were significantly higher among controls (0.013 vs. 0.007 ng/mL; and 18.0 vs. 15.0 ng/mL). Lead was associated with stroke in univariate and multivariate analysis (OR = 1.65 (95% CI, 1.09–2.50) and OR = 1.91 (95% CI, 1.20–3.04), respectively). Gold and cerium showed an inverse association with stroke in multivariate analysis (OR = 0.81 (95% CI, 0.69–0.95) and OR = 0.50 (95% CI, 0.31–0.78)). Future studies are needed to elucidate the potential sources of exposure and disclose the mechanisms of action.

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Section: Introductionmentioning

confidence: 93%

Section: Selection Of Elements and Sample Preparationmentioning

confidence: 99%

Section: Analytical Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between Heavy Metals and Rare Earth Elements with Acute Ischemic Stroke: A Case-Control Study Conducted in the Canary Islands (Spain)

Medina-Estévez

Zumbado

Luzardo

et al. 2020

Toxics

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Association of multiple trace metals in scalp hair with glioma risk: the mediating role of inflammation

Yan,

You,

Wang

et al. 2024

Ann Clin Transl Neurol

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ObjectiveTo explore the relationship between 35 trace metals in scalp hair and the glioma risk as well as the potential mediating roles of 27 plasma inflammatory cytokines.MethodsA case–control study involving 228 participants was performed in southeastern China. Trace metals in scalp hair were analyzed using inductively coupled plasma mass spectrometry, and multiplex cytokines were detected based on Luminex® technology. The least absolute shrinkage and selection operator (LASSO) regression in combination with four machine learning methods were used to select trace metals associated with gliomas. The joint exposure effect of trace metals was estimated using the generalized weighted quantile sum (gWQS) regression and quantile‐based g‐computation (qgcomp) algorithms.ResultsBoth LASSO regression and random forest algorithms identified five trace metals (gadolinium [Gd], lithium [Li], thulium [Tm], thorium [Th], and molybdenum [Mo]) associated with gliomas. After adjustments for potential confounders, Gd (odds ratio [OR] = 2.84, 95% confidence interval [CI]: 1.89–4.43) and Li (OR = 1.77, 95% CI: 1.04–3.02) concentrations were positively associated with glioma risk, while Tm (OR = 0.36, 95% CI: 0.17–0.73) and Th (OR = 0.45, 95% CI: 0.28–0.71) exhibited inverse associations. Both gWQS and qgcomp algorithms showed Gd contributed most to the mixture effect. Moreover, there was a significant interaction between Gd and Tm or Th on glioma risk (p < 0.05). Notably, granulocyte–macrophage colony‐stimulating factor (GM‐CSF) mediated the association between Gd exposure and glioma risk by 25.75%.InterpretationThese findings suggest potential associations of certain trace metals, especially for Gd, with glioma risk, and may provide new insights into the mechanisms underlying from an inflammatory response perspective.

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Artisanal mining of monazite and cassiterite in the Amazon: Potential risks of rare earth elements for the environment and human health

da Costa Alves Filho,

da Silveira Pereira,

Dias

et al. 2024

Environmental Management

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A artisanal mining is applied on a large scale in developing countries, and in the Amazon region, the scenario is no different. This method of mineral exploration generally does not employ mitigation techniques for potential damages and can lead to various environmental problems and risks to human health. The objectives of this study were to quantify the concentrations of Rare Earth Elements (REEs) and estimate the environmental and human health risks in artisanal mining areas for cassiterite and monazite in the Amazon region, as well as to understand the dynamics of this risk over time after exploitation. A total of 32 samples of waste classi ed as sterile and mining reject in active areas, as well as in areas deactivated for one and ten years, were collected. Soil samples were also collected in a forest area considered as a reference site. The concentrations of REEs were quanti ed using alkaline fusion and ICP-MS. The results were used to calculate pollution indices and environmental and human health risks.REEs showed higher concentrations in anthropized areas. Pollution and environmental risk levels were higher in areas deactivated for one year, with considerable contamination factors for Gd and Sm and signi cant to extreme enrichment factors for Sc. Human health risks were low in all studied areas. The results indicate that artisanal mining of cassiterite and monazite has the potential for contamination and enrichment by REEs.

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Concentration of heavy metals and rare earth elements in patients with brain tumours: Analysis in tumour tissue, non-tumour tissue, and blood

Cited by 31 publications

References 46 publications

Association between Heavy Metals and Rare Earth Elements with Acute Ischemic Stroke: A Case-Control Study Conducted in the Canary Islands (Spain)

Association between Heavy Metals and Rare Earth Elements with Acute Ischemic Stroke: A Case-Control Study Conducted in the Canary Islands (Spain)

Association of multiple trace metals in scalp hair with glioma risk: the mediating role of inflammation

Artisanal mining of monazite and cassiterite in the Amazon: Potential risks of rare earth elements for the environment and human health

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