Concentrated Growth Factor Enhanced Fat Graft Survival: A Comparative Study

Hu, Yun; Jiang, Yichen; Wang, Muyao; Tian, Weidong; Wang, Hang

doi:10.1097/dss.0000000000001337

Cited by 39 publications

(40 citation statements)

References 20 publications

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“…Although under treatment with CGF extracts, higher cells proliferation in a dose‐dependent manner was approved by Jin et al, enhanced cell migration, and differentiation in the low doses (<50%) of CGF was noticeable (Jin et al, ). Two studies compared effect of CGF with PRF, and the results show that PRF is more efficient in osteogenic differentiation of stem cells, while CGF is more efficient in vascular differentiation (Hong et al, ; Hu et al, ).…”

Section: Resultsmentioning

confidence: 99%

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In vitro and in vivo effects of concentrated growth factor on cells and tissues

Tabatabaei

Aghamohammadi

Tayebi

2020

J Biomedical Materials Res

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This article reviews the biological outcome of the concentrated growth factor (CGF), a new platelet derivative used for tissue regeneration, in published articles related to the use of this product in basic and clinical studies. An electronic literature research using PubMed and SCOPUS was performed using combination of keywords: “concentrated growth factor” (OR “CGF”), AND “stem cells,” AND “cells” OR “cell proliferation” OR “cell migration” OR “cell differentiation,” AND “repair” OR “survival” OR “revitalization,” AND “tissue” OR “bone.” Forty‐five articles that were published between 2012 and 2020 met the inclusion criteria. These studies have used CGF as fresh solid form, freeze‐dried, membrane, extract, or exudate. Most studies demonstrate the positive effects of CGF in a dose‐dependent manner under certain concentrations. Studies comparing CGF with other platelet concentrates, report lower efficiency, no statistically significant differences, or better results for CGF. Combination of CGF with stem cells and biomaterials significantly improves bone regeneration and the effect of allograft or collagen membrane is better than CGF alone. For a better examination of the biological outcomes of CGF, the standardization of CGF preparation regarding the choice of the test tube material for blood collection, the required volume of blood, the necessary count of platelets in CGF, and the most appropriate type of CGF are recommended.

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Section: Resultsmentioning

confidence: 99%

“…However, four studies showed that a high dose of CGF does not have a positive effect. In more efficient in vascular differentiation (Hong et al, 2018;Hu et al, 2018).…”

Section: Effect Of Cgf On Stem Cellsmentioning

confidence: 99%

In vitro and in vivo effects of concentrated growth factor on cells and tissues

Tabatabaei

Aghamohammadi

Tayebi

2020

J Biomedical Materials Res

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“…PRP'ye göre daha yoğundur ve daha yüksek miktarlarda büyüme faktörü içermektedir ve trombin olmadan aktive olabilmektedir (16,17). Aynı zamanda vasküler dayanıklılık, neovaskülarizasyon ve anjiogenezde rol alan CD34+ kök hücre içermektedir (15,23). CGF'in yumuşak doku iyileşmesinde PRP'ye göre daha etkili olduğu raporlanmıştır (24).…”

Section: Cerrahi Teknikunclassified

“…Klinik ve deneysel çalışmalarda CGF'in kemik, kıkırdak ve periferik sinir doku üzerine proliferatif etkileri ve greftlerin yaşayabilirliği üzerine olumlu etkileri gösterilmiştir (17,18). (17)(18)(19)23,27). Bu çalışmada ise CGF'in flep yaşayabilirliği üzerinde de anlamlı artış sağladığı görüldü.…”

Section: Cerrahi Teknikunclassified

“…İnflamasyon skorları düşük olmakla beraber istatistiksel olarak anlamlı bulunmadı. CGF'in kıkırdak, kemik ve yağ üzerine etkisini inceleyen çalışmalarda da benzer şekilde inflamasyon skorları daha az, vaskülarizasyon skorlarının daha yüksek olduğu gösterilmiştir (18,23,27). Trombosit ürünleri ile yapılan diğer çalışmalarda da benzer şekilde vaskülarizasyon sayılarında artış ve inflamasyon skorlarında azalma görülmüştür (1,(9)(10)(11)13,14).…”

Section: Cerrahi Teknikunclassified

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Konsantre büyüme faktörünün random patern cilt flep yaşayabilirliği üzerine etkisi: deneysel çalışma

Gürsoy

Koca

Alişik

et al. 2020

Journal of Health Sciences and Medicine

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Introduction: Random pattern skin flaps are used frequently for the reconstruction of random pattern skin defects from various causes in plastic and reconstructive surgery. Most frequent complication with these flaps is the necrosis of distal parts due to inadequate blood supply. Various types of techniques have been defined to avoid and reduce flap loss. The aim of this study is, for the first time, to evaluate the effect of concentrated growth factor (CGF), which is derived from whole blood and is rich in growth factors, on the survival of random pattern skin flaps. Material and Method: Fifty Sprague-Dawley rats were used for the study. Forty of them were used for the experiment group and ten for the preparation of CGF. Distal based 3x9 cm McFarlene flaps were elevated from the back of the rats and in CGF group (n:20), CGF matrix was placed before closure. No treatment was given to the control group (n:20). On postoperative day 7, the flaps were evaluated by photographic, scintigraphic, and histopathological methods. Results: The median rate of surviving flap areas in control group was 53% (47-58). In CGF group the median rate of flap viability was %58 (55-64). The higher flap viability rates obtained from CGF applied group was found to be statistically significantly higher from control group (p<0,001). For the scintigraphic perfusion area evaluations, the median rate of flap perfusion was 54% (51-60) for the control group and 61% (59-64) for the CGF group. The higher flap perfusion rates obtained from CGF applied group was found to be statistically significantly higher from control group (p=0,001). The median rate of vascularity scores in CGF treated group was 10,0 (8,25-11,75) and 7,5 (6,25-9,00) in control group. The difference was found to be statistically significantly higher in the study group (p=0,003). Inflammation scores were not found to be statistically significantly different (p=0,246). Conclusions: This study shows that locally applied CGF under skin flap increases flap viability which might be associated with the increase in angiogenesis. This study for the first time shows that in flap surgery, applying CGF which is rich in growth factors, might have favorable effects on the flaps that are prone to ischemia but further studies are needed.

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Effect of Platelet-Rich Fibrin on Fat Grafting in Animal Models: A Meta-Analysis

Liu

et al. 2019

Aesth Plast Surg

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Concentrated Growth Factor Enhanced Fat Graft Survival: A Comparative Study

Abstract: In this preliminary study, CGF treatment improved the survival and quality of fat grafts.

Cited by 39 publications

References 20 publications

In vitro and in vivo effects of concentrated growth factor on cells and tissues

In vitro and in vivo effects of concentrated growth factor on cells and tissues

Konsantre büyüme faktörünün random patern cilt flep yaşayabilirliği üzerine etkisi: deneysel çalışma

Effect of Platelet-Rich Fibrin on Fat Grafting in Animal Models: A Meta-Analysis

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