Computers and quality control in nuclear medicine

Brookeman, Valerie A.

doi:10.1016/s0001-2998(78)80035-x

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…It is well known that there is a compromise between sensitivity and resolution in collimated nuclear medicine systems [3,4]. The detectability of the radiopharmaceutical concentration in abnormalities depends on the interplay between various parameters, such as the positron emission tomography (PET) scanner's sensitivity, the amount of activity, the ratio of the target-to-background activity, the size of the target, and the irradiation time, among others [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Information Capacity of Positron Emission Tomography Scanners

et al. 2018

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Background: The aim of the present study was to assess the upper information content bound of positron emission tomography (PET) images, by means of the information capacity (IC). Methods: The Geant4 Application for the Tomographic Emission (GATE) Monte Carlo (MC) package was used, and reconstructed images were obtained by using the software for tomographic image reconstruction (STIR). The case study for the assessment of the information content was the General Electric (GE) Discovery-ST PET scanner. A thin-film plane source aluminum (Al) foil, coated with a thin layer of silica and with a 18F-fludeoxyglucose (FDG) bath distribution of 1 MBq was used. The influence of the (a) maximum likelihood estimation-ordered subsets-maximum a posteriori probability-one step late (MLE-OS-MAP-OSL) algorithm, using various subsets (1 to 21) and iterations (1 to 20) and (b) different scintillating crystals on PET scanner’s performance, was examined. The study was focused on the noise equivalent quanta (NEQ) and on the single index IC. Images of configurations by using different crystals were obtained after the commonly used 2-dimensional filtered back projection (FBP2D), 3-dimensional filtered back projection re-projection (FPB3DRP) and the (MLE)-OS-MAP-OSL algorithms. Results: Results shown that the images obtained with one subset and various iterations provided maximum NEQ values, however with a steep drop-off after 0.045 cycles/mm. The single index IC data were maximized for the range of 8–20 iterations and three subsets. The PET scanner configuration incorporating lutetium orthoaluminate perovskite (LuAP) crystals provided the highest NEQ values in 2D FBP for spatial frequencies higher than 0.028 cycles/mm. Bismuth germanium oxide (BGO) shows clear dominance against all other examined crystals across the spatial frequency range, in both 3D FBP and OS-MAP-OSL. The particular PET scanner provided optimum IC values using FBP3DRP and BGO crystals (2.4829 bits/mm2). Conclusions: The upper bound of the image information content of PET scanners can be fully characterized and further improved by investigating the imaging chain components through MC methods.

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Section: Introductionmentioning

confidence: 99%

Information Capacity of Positron Emission Tomography Scanners

et al. 2018

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“…In the nineteen-twenties, Walter A. Shewart, with a group of experts, established the scientific ground for quality control at Bell Telephone Laboratories Shewhart (1931). It is only in the nineteen fifties that quality control procedures were employed to ensure the precision of hospital laboratory machines used in biology, nuclear medicine, drug industry and other medical domains Anderson (1982); Batson et al (1951); Brookeman (1978); Hollinger & Lansing (1956); Loynd (1962); Pribr & Shuster (1967); Waid & Hoffmann (1955). Later, in the nineteen seventies, the use of these methods shifted to the monitoring of the effect of treatments on patients Kinsey et al (1989); Morgan et al (1987); Robinson & Williamson (1974); Walters & Griffin (1986); Wohl (1977), and then to other more complex levels such as the performance of departements Chamberlin et al (1993); The Inquiry into the management of care of children receiving complex heart surgery at the Bristol Royal Infirmary (2001), hospitals Sellick (1993), regions Tillett & Spencer (1982) or nation-wide processes Hand et al (1994).…”

Section: Introductionmentioning

confidence: 99%