Computer-Synthesis of an Interference Color Chart of Human Tear Lipid Layer, by a Colorimetric Approach

Goto, Eiki; Doğru, Murat; Kojima, Takashi; Tsubota, Kazuo

doi:10.1167/iovs.03-0260

Cited by 73 publications

(55 citation statements)

References 31 publications

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“…To the best of our knowledge, our approach based on measurements of the OCT reflectance to obtain super-resolved thickness maps is new in the OCT field. Our lipid layer maps are similar to the ones obtained with colorimetric [41,42] and reflectometric approaches [9,37]. OCT provides two advantages in comparison to the other reported methods for visualizing the lipid layer.…”

Section: Discussionsupporting

confidence: 76%

Super-resolved thickness maps of thin film phantoms and in vivo visualization of tear film lipid layer using OCT

Santos

Schmetterer²,

Triggs

et al. 2016

Biomed. Opt. Express

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In optical coherence tomography (OCT), the axial resolution is directly linked to the coherence length of the employed light source. It is currently unclear if OCT allows measuring thicknesses below its axial resolution value. To investigate spectral-domain OCT imaging in the super-resolution regime, we derived a signal model and compared it with the experiment. Several island thin film samples of known refractive indices and thicknesses in the range 46 − 163 nm were fabricated and imaged. Reference thickness measurements were performed using a commercial atomic force microscope. In vivo measurements of the tear film were performed in 4 healthy subjects. Our results show that quantitative super-resolved thickness measurement can be performed using OCT. In addition, we report repeatable tear film lipid layer visualization. Our results provide a novel interpretation of the OCT axial resolution limit and open a perspective to deeper extraction of the information hidden in the coherence volume.

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Section: Discussionsupporting

confidence: 76%

Super-resolved thickness maps of thin film phantoms and in vivo visualization of tear film lipid layer using OCT

Santos

Schmetterer²,

Triggs

et al. 2016

Biomed. Opt. Express

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show abstract

“…33 In this study, tear film lipid spread time was defined as the time from the end of a complete blink until a stable lipid layer fringe pattern was attained in the DR-1 interferometer. Lipid spread time was measured three times and the mean value was calculated.…”

Section: Dr-1 Lipid Layer Interferometrymentioning

confidence: 99%

Alterations of the tear film and ocular surface health in chronic smokers

Matsumoto

Doğru

Goto

et al. 2008

Eye

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Objective To investigate the effects of chronic smoking on ocular surface and tear functions. Methods Fifteen right eyes of 15 healthy chronic smokers (9 men, 6 women; age range: 36-47 years) who smoked 20 cigarettes per day for 20 years and 20 eyes of 20 control nonsmokers (12 men, 8 women; age range: 38-43 years) were included in this prospective study. All subjects underwent measurements of breath and haemoglobin CO concentration, tear lipid layer interferometry, evaporimetry, tear film break-up time (TBUT), Schirmer's I test, corneal fluorescein staining, conjunctival impression, and brush cytology. Results The mean Hb CO level was significantly higher in smokers compared to non-smokers. TBUT was also significantly shorter in smokers. Tear lipid layer showed significant slowing in spread over the tear film with a concomitant significant increase in tear evaporation rate. Conjunctival impression cytology revealed significant loss of goblet cells and squamous metaplasia in smokers. Brush cytology showed significant conjunctival neutrophil infiltration in smoker subjects. Conclusion Chronic smoking induced distinctive quantitative and qualitative disturbances on the ocular surface health.

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“…Choosing lower values decreases the test sensibility and increases its specificity. Others tests to evaluate the tear film stability are: the interferometry, that measures the central precorneal tear film thickness noninvasively using an interference thin-film thickness measurement device (32)(33)(34) and the meibomiometry, that uses a new laser meibometer to measure meibomian lipid levels on the lid margin by blotting meibomian gland oil into a piece of plastic and monitoring its transparency in order to calculate the amount of oil and its rate of delivery (35) . These tools are not commonly used in daily routine.…”

Section: Clinical Evaluation Of the Ocular Surface: Signs And Symptomsmentioning

confidence: 99%

Ocular surface adverse effects of ambient levels of air pollution

Torricelli¹,

Novaes²,

Matsuda³

et al. 2011

Arq. Bras. Oftalmol.

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Computer-Synthesis of an Interference Color Chart of Human Tear Lipid Layer, by a Colorimetric Approach

Abstract: A new tear interference color chart was developed in this study, which may be of benefit in converting tear interference color information to data describing the thickness of the tear film lipid layer.

Cited by 73 publications

References 31 publications

Super-resolved thickness maps of thin film phantoms and in vivo visualization of tear film lipid layer using OCT

Super-resolved thickness maps of thin film phantoms and in vivo visualization of tear film lipid layer using OCT

Alterations of the tear film and ocular surface health in chronic smokers

Ocular surface adverse effects of ambient levels of air pollution

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