Computer modeling of the optical properties and heating of spherical gold and silica-gold nanoparticles for laser combined imaging and photothermal treatment

Abstract

Recently, several groups of investigators (Anderson, Halas, Zharov, El-Sayed and their co-workers (Pitsillides et al 2003 Biophys. J. 84 4023-31, Zharov et al 2003 Appl. Phys. Lett. 83 4897-9, Zharov et al 2004 Proc. SPIE 5319 291-9, Loo et al 2005 Nano Lett. 5 709-11, Gobin et al 2007 Nano Lett. 7 1929-34, Fu et al 2008 Nanotechnology 19 045103, Huang et al 2006 J. Am. Chem. Soc. 128 2115-20, Jain et al 2006 J. Phys. Chem. B 110 7238-48, Jain et al 2007 Nano Today 2 18-29)) demonstrated, through pioneering results, the great potential of laser thermal therapy of cells and tissues conjugated with gold nanoparticles. It was also proposed to use combined diagnostics and therapy on the basis of nanoparticle selection for achievement of efficient contrast for laser imaging applications, as well as for photothermal therapy. However, the current understanding of the relationship between optical properties (absorption, backscattering) of nanoparticles, the efficiency of nanoparticle heating and the possibility to use them for combined imaging and therapy is limited. Here, we report the results of computer modeling of optical absorption and backscattering properties and laser heating of gold and silica-gold spherical nanoparticles for laser combined imaging and photothermal treatment of cells and tissues conjugated with nanoparticles. The efficiencies of nanoparticle heating and backscattering by nanoparticles, depending upon their radii, structure and optical properties of the metal, were investigated. This paper focuses on the analysis and determination of appropriate ranges of nanoparticle sizes for the purposes of laser combined imaging and photothermal treatment. The possibility to use spherical gold and silica-gold nanoparticles in determined ranges of radii for these purposes for laser wavelengths 532 and 800 nm is investigated.

Experimental Validation and Simulation of Fourier and Non-Fourier Heat Transfer Equation during Laser Nano-Phototherapy of Lung Cancer Cells: An <i>in Vitro</i> Assay

“…The results indicate that the concentration of NSs had significant effects on the amount of heat generated at a given power density. For core-shell, the NP efficiency parameter has the form [49] ( ) ( ) …”

Analysis of nanoparticles optical propagation influence in biological tissue simulating phantoms

“…Nanoparticles have also an important role in the field of diagnosis, offering a solution to improve the disadvantages of conventional agents, such as poor contrast, photobleaching, and low chemical and optical stability in a biological environment [4]. During the last years, a big effort had been devoted to the research of different types of nanostructures, synthesis and manufacturing methods, new biomedical applications and the study of the optical and thermal effects in the medium surrounding them [5]. The use of models that take into account those effects has become an important tool in order to predict the response of biological environments when nanoparticles are administered in the target tissue.…”

Influence of Shell Parameters on Optical Properties of Spherical Metallic Core‐Oxide Shell Nanoparticles

“…There are many reasons for this interest in nanophotonics including applications of NPs in different fields, such as catalysis [1,2], nanoelectronics [3,4], nanooptics and nonlinear optics [5,6], and energetic nanotechnology (e.g., photovoltaics [7] and light-to-heat conversion [8,9]). Laser applications in nanotechnology include laser nanobiomedicine [10][11][12][13][14][15] with determination of selected properties of NPs [16,17] and laser processing of metallic NPs in nanotechnology [18][19][20][21][22][23]. Metallic NPs are mostly interesting for different nanotechnologies among other NPs.…”

“…NPs have been extensively studied in recent years due to their wide range of potential applications . Thermooptical analysis and selection of the properties of metal NPs for laser applications in nanotechnology were carried out in [9,16,17,[25][26][27][28][29][30]. Metal NPs have their LSPR in the ultraviolet and visible spectral intervals of optical radiation.…”

“…For example, SiO 2 -gold and gold-SiO 2 coreshell NPs are widely investigated and applied in experiments [10,16,[31][32][33]. The position of the LSPR for such core-shell NPs is strongly influenced by the presence of the geometrical characteristics: the core radius, the thickness of the oxide layer, and the ratio between them [10,16,[31][32][33].…”