Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study*1methodology, correlation between eyes, and effect of refractive errors

Wong, Tien Yin; Knudtson, Michael D.; Klein, Ronald; Klein, Barbara E. K.; Meuer, Stacy M.; Hubbard, Larry D.

doi:10.1016/j.ophtha.2003.09.039

Cited by 418 publications

(354 citation statements)

References 36 publications

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“…These results show a good correlation between right and left eyes for CRAE and CRVE and a moderate correlation for AVR, being similar to those reported in [11] and [12]. The agreement between measurements from the right and left eyes can be observed in the Bland-Altman plots depicted in Fig.…”

Section: Experimental Validationsupporting

confidence: 88%

“…The mean error and the Pearson correlation coefficient between measurements from the right and left eyes in the CHSJ dataset are shown in Table 2, where the correlation coefficients reported by the Beaver Dam Eye Study (BDES) [11] and Leung et al [12] are also included. These results show a good correlation between right and left eyes for CRAE and CRVE and a moderate correlation for AVR, being similar to those reported in [11] and [12].…”

Section: Experimental Validationmentioning

confidence: 99%

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Computer-aided diagnosis system for the assessment of retinal vascular changes

Dashtbozorg

Mendonça

Penas

et al. 2014

Proceedings of the Ophthalmic Medical Image Analysis First International Workshop

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Abstract. This paper presents an automatic application that provides several retinal image analysis functionalities, namely vessel segmentation, vessel width estimation, artery/vein classification and optic disc segmentation. A pipeline of these methods allows the computation of important vessel related indexes, namely the Central Retinal Arteriolar Equivalent (CRAE), Central Retinal Venular Equivalent (CRVE) and Arteriolar-to-Venular Ratio (AVR), as well as various geometrical features associated with vessel bifurcations. The results for AVR estimation were assessed using the images of INSPIRE-AVR dataset; for this dataset, the mean error of the measured AVR values with respect to the reference was identical to the one achieved by a medical expert. The estimation of the CRAE, CRVE and AVR values on 480 images from 120 subjects have shown a significant correlation between right and left eyes and also between images of same eye acquired with different camera fields of view.

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Section: Experimental Validationsupporting

confidence: 88%

Section: Experimental Validationmentioning

confidence: 99%

Computer-aided diagnosis system for the assessment of retinal vascular changes

Dashtbozorg

Mendonça

Penas

et al. 2014

Proceedings of the Ophthalmic Medical Image Analysis First International Workshop

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“…Measurement of retinal vascular calibre Retinal vascular calibre was measured using a computer-assisted vessel measurement system (Retinal Analysis; Optimate, Madison, WI, USA) that uses microdensitometry to detect the vessel edge [20]. The measurement reflects the width of the erythrocyte column.…”

Section: Study Populationmentioning

confidence: 99%

“…The development of retinal imaging technology has allowed non-invasive measurement of early structural changes in the retinal microvasculature [5,6]. Using these new methods, several studies have shown that changes in retinal vascular calibre are associated with the risk of developing type 2 diabetes [7,8] and impaired fasting glucose (IFG) [9] and, among people with diabetes, with progression of retinopathy [10] and nephropathy [11].…”

Section: Introductionmentioning

confidence: 99%

The relationship of retinal vascular calibre to diabetes and retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study

et al. 2007

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Aims/hypothesis The aim of the study was to examine the relationship of retinal vascular calibre with glucose intolerance, diabetes and retinopathy in a population-based cohort. Methods The Australian Diabetes, Obesity and Lifestyle study recruited adults aged ≥25 years old from across Australia. Participants were classified using an oral glucose tolerance test as having normal glucose tolerance (NGT), impaired glucose tolerance (IGT), impaired fasting glucose (IFG), known diabetes or newly diagnosed diabetes. Digital retinal photographs were taken of all participants with diabetes, IGT and IFG, and a sample of those with NGT, and graded for the presence of retinopathy. Retinal vascular calibre was measured from photographs by a computerassisted method.Results Of the 1,998 participants with gradable retinal images, 16% had known diabetes, 17% newly diagnosed diabetes, 42% IGT, 6% IFG and 19% NGT. After multivariable adjustment, retinal arteriolar calibre was significantly larger in people with known diabetes (178.9 μm) compared with participants with NGT (174.6 μm, p=0.02), IGT/IFG (175.5 μm, p=0.02) or newly diagnosed diabetes (175.6 μm, p=0.047). One SD increase in mean arteriolar calibre was associated with higher odds of diabetes compared with NGT (odds ratio [OR]=1.28, 95%CI=1.06-1.55). After multivariable adjustment, each SD increase in venular calibre was associated with higher odds of having retinopathy in persons with IGT/IFG (OR=1.78, 95% CI=1.36-2.34) or in persons with diabetes (OR=1.68, 95% CI=1.23-2.29). Conclusions/interpretation Diabetes is associated with larger retinal arteriolar calibre and retinopathy with larger retinal venular calibre. The contrasting associations may reflect different underlying pathophysiological processes in the natural history of diabetes.

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“…The retinal vascular calibre was measured using the computer program IVAN version 1.30 (University of Wisconsin, Madison, WI, USA) according to a detailed protocol that has been described by Hubbard and Wong. 16,17 All vessels coursing through an area one-half to one-disc diameter from the optic disc margin (double arrow in Figure 1) were measured. The mean vessel calibre of the largest six arteries was termed central retinal artery equivalent (CRAE) while that of the largest six venules was coined central retinal vein equivalent (CRVE) using formulas developed by Hubbard et al 16 and later modified by Knudtson et al 18 …”

Section: Measurement Of Retinal Vascular Calibrementioning

confidence: 99%

Association of retinal vessel calibre and visual outcome in eyes with diabetic macular oedema treated with ranibizumab

Moradi

Sepah

Ibrahim

et al. 2014

Eye

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Purpose The study aims to identify the association between the baseline retinal vascular calibre and visual outcome of patients with diabetic macular oedema (DMO) treated with intravitreal ranibizumab. Methods The 1-M field (as defined in the ETDRS study) of the digital colour fundus photographs of DMO patients who had been treated primarily with ranibizumab in a clinical trial was assessed. Of the 84 patients, 25 had gradable retinal photographs that could be subjected to analyses by the Interactive Vessel Analysis (IVAN) software at baseline. The average retinal vascular calibre of the six largest venules (CRVE) and the six largest arterioles (CRAE) in the peripapillary area (0.5 and 1 disc diameter from the optic disc margin) was measured. The relationship between CRVE and CRAE at baseline and the change in visual acuity at month 12 was assessed using the Mann-Whitney U test. Results Ten eyes from 10 patients who had shown an improvement of Z2 lines of best corrected visual acuity (BCVA) at month 12 had a wider baseline CRVE (248.3±24.5 mm) compared with the 15 eyes from 15 patients who did not show the improvement of Z2 lines (226.6 ± 44.8 mm, Po0.05). The baseline CRAE did not differ significantly in these patients (156.1 ± 22.7 vs 142 ± 17.5 mm, P ¼ 0.17). Conclusions A wider baseline retinal venular calibre may be a predictor of better visual outcome in DMO eyes treated with ranibizumab. Further prospective studies with a larger sample size and a broader range of disease severity and visual acuity are needed to confirm this finding.

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Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study*1methodology, correlation between eyes, and effect of refractive errors

Cited by 418 publications

References 36 publications

Computer-aided diagnosis system for the assessment of retinal vascular changes

Computer-aided diagnosis system for the assessment of retinal vascular changes

The relationship of retinal vascular calibre to diabetes and retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study

Association of retinal vessel calibre and visual outcome in eyes with diabetic macular oedema treated with ranibizumab

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