Disaster risk mitigation has become a global urgent need. Similarly to other natural hazards, earthquakes may cause significant damage on a large scale. In Europe and in other regions with dense urbanization, seismic events can heavily impact historical city centres due to the several structural fragilities. These centers are often part of the worldwide cultural heritage and their preservation is considered a strategic issue. Furthermore, earthquakes may have severe negative short-term economic effects on the impacted communities and adverse longer-term consequences for economic growth. For this reason, the development of an efficient approach for urban seismic risk assessment becomes essential. An original approach is proposed, based on performance concepts and multidisciplinary perspectives. The procedure is applied for validation to the city center of Concordia Sulla Secchia (Italy), damaged by the 2012 Pianura Padana Earthquake (PPE), comparing predicted damage scenarios with the actual post-seismic survey data.