Computer-aided design and synthesis of CdTe@SiO₂core-shell molecularly imprinted polymers as a fluorescent sensor for the selective determination of sulfamethoxazole in milk and lake water

Abstract

In this work, a molecular dynamics simulation method was introduced to compute the preassembled system of molecular imprinted polymers for sulfamethoxazole monomer. The results revealed that the ratio of sulfamethoxazole as template molecule to 3-aminopropyltriethoxysilane as functional monomer to tetraethylorthosilicate as cross-linker of 10:10:40 led to the most stable template-functional monomer cluster. Based on the result of computational simulation, CdTe@SiO core-shell imprinted polymers, a cadmium telluride quantum dots layer on the surface of aminofunctionalized SiO , were synthesized as the fluorescent sensor. Then, a series of measures were used to characterize the structure and morphology to get optimal sensors. The concentration range was 5.0-30.0 μmol/L between molecular imprinted polymers at CdTe at SiO , and sulfamethoxazole of the fluorescence intensity. To further verify the reliability and accuracy of the fluorescent sensor, the application was successfully by analyzing sulfamethoxazole in pure milk and lake water. The results showed the recoveries were above 96.89% with a relative standard deviation of 1.25-5.45%, and the fluorescence sensor with selective recognition provides an alternative solution for the determination of sulfamethoxazole.

Core−Shell Molecularly Imprinted Polymers on Magnetic Yeast for the Removal of Sulfamethoxazole from Water

“…However, if the ratio of monomer to crosslinker is too high, it will make the extraction of the template difficult due to the excessive rigidity of the MIP. Considering the referred considerations and conclusions from other studies [ 40 , 41 ], the ratio of monomer and crosslinker was selected to be 1:5.…”

Highly Selective Fluorescence Sensor Based on Graphene Quantum Dots for Sulfamethoxazole Determination

“…In the presence of SMZ ( Figure 5B), the intensity of GQDs@SMIP was strongly quenched at pH values between 7 and 9. It is well-established that if the pH is excessively low or high, the imprinted silica shell can hydrolyze and the template cavities can be destroyed [2,36,37]; this affects the stability as well as the ability of the GQDs@SMIP template to recognize the target analyze. Based on these results, we realized that a pH in the range of 7 to 9 is suitable for SMZ detection.…”

“…Sulfamethoxazole (SMZ) is one of the numerous antibiotics belonging to the sulfonamide family. SMZ is used widely as an antibacterial agent in drugs for infectious diseases, animal-derived food, and aquatic environments [1,2]. As SMZ cannot be eliminated effectively through common water or food treatment processes, there is a probability of an excess amount of SMZ entering the human body.…”

“…Therefore, with combined MIP technology, the selectivity of a GQDs-based sensor would be improved significantly. In recent years, SMZ fluorescence sensors replied on MIP have been reported [2,24,25]. They have emerged as powerful techniques not only because of their strong selectivity but also due to their simplicity, easy-preparation and inexpensive cost, when compared with other SMZ sensing methods which require expensive instruments and complex operating processes [26][27][28][29].…”

Facile and versatile strategy to prepare magnetic molecularly imprinted particles based on the coassembly of magnetic nanoparticles and amphiphilic random copolymers

“…Molecularly imprinted polymers (MIPs) have been recognized as artificial recognition materials, which possess binding sites complementary in size and shape to the templates for specifically recognizing targeted molecules. So MIPs have been widely applied in the field of sensors , catalysis , separation and purification , and so on. In recent years, magnetic molecularly imprinted polymer (MMIPs) have attracted extensive attention .…”